Zobrazeno 1 - 10
of 19
pro vyhledávání: '"William F. Holt"'
Autor:
Mark R. Hellberg, Bryon S. Severns, William F. Holt, Richard Young, Richard A. Glennon, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen, Curtis R. Kelly, Marsha A. McLaughlin, Jesse A. May
Publikováno v:
Journal of medicinal chemistry. 58(22)
Recently, it has been reported that 5-HT2 receptor agonists effectively reduce intraocular pressure (IOP) in a nonhuman primate model of glaucoma. Although 1-[(2S)-2-aminopropyl]indazol-6-ol (AL-34662) was shown to have good efficacy in this nonhuman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efded27acf90f8c38ea878165340de3
https://pubmed.ncbi.nlm.nih.gov/26551970
https://pubmed.ncbi.nlm.nih.gov/26551970
Publikováno v:
Survey of Ophthalmology. 50:S46-S54
Topical treatment of ocular bacterial infection is practiced widely, and the choice of the antibacterial agent depends on the nature of the infection, including the susceptibility of the organism, the tissue affected, and the safety profile of the ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8160db6cdf479a69da16080656849e4d
https://doi.org/10.1016/j.survophthal.2005.05.003
https://doi.org/10.1016/j.survophthal.2005.05.003
Autor:
Graham J. Durant, Lu Zhang, Michael E. Perlman, Suchitra Chari, Teresa Wolcott, Ruth C. Lavin, Cassandra Kirk, Robert N. McBurney, Seetharamaiyer Padmanabhan, William F. Holt, James B. Fischer, Paresh Thakker, Deborah Daly, David Berlove, Jinqing Guo, Kathy J Burke-Howie, Deke Moore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3151-3155
Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545b06647e77c3c4b3671778740d1ae7
https://doi.org/10.1016/s0960-894x(01)00644-8
https://doi.org/10.1016/s0960-894x(01)00644-8
Autor:
Irene M. Purcell, Teresa M. Schelhorn, William F. Holt, S S Ellery, Wester Ronald Thure, William R. Murphy, Michael L. Mangiapane, Kelly A. Simpson, Andrew H. Smith
Publikováno v:
Drug Development Research. 34:361-368
Human and monkey renin are very similar, but differ from the renin of species commonly used in screening antihypertensive agents (i.e., dog and rat). This has necessitated the evaluation of renin inhibitors (Rls) in primate models. We have found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82f26bf0a751ac21850b65adcd8c46a7
https://doi.org/10.1002/ddr.430340408
https://doi.org/10.1002/ddr.430340408
Autor:
William F. Holt, M.A. Ravi Kiron, Robert L. Rosati, Kleinman Edward F, Andrew H. Fray, Irene M. Purcell, William R. Murphy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:589-592
CP-71,362 (Boc-Phe-His-hexahydroPhe[OH]Leu-Lys-Phe) has been identified as the most potent inhibitor of rat plasma renin (IC50 = 3 nM) and dog plasma renin (IC50 = 3 pM) to date and thus can be used as an important experimental tool in the study of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1fae6b40c19de1b4412f1a44c47c9e
https://doi.org/10.1016/s0960-894x(01)80160-8
https://doi.org/10.1016/s0960-894x(01)80160-8
Autor:
Joseph T. MacAndrew, William F. Holt, S S Ellery, William R. Murphy, Irene M. Purcell, Kleinman Edward F, Andrew H. Smith, Michael L. Mangiapane
Publikováno v:
Clinical and Experimental Hypertension. 16:507-533
Most renin inhibitors are primate-specific. In the present paper, we describe the effects of CP-71,362, a pentapeptide which preferentially inhibits canine (and to a lesser extent, rat) plasma renin. Vs. the canine enzyme, its affinity (IC50 = 3.3 x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d7c7cb6cfe967135ad86d1fed081e3
https://doi.org/10.3109/10641969409067959
https://doi.org/10.3109/10641969409067959
Publikováno v:
Journal of Cardiovascular Pharmacology. 21:791-796
Renal and systemic hemodynamics were studied in rats 1 month after induction of myocardial infarction by ligation of the left coronary artery. The mean arterial pressure, heart rate, and cardiac index were not different from controls, but there were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9cd0f7721d91804ff7361de1e7b947
https://doi.org/10.1097/00005344-199305000-00016
https://doi.org/10.1097/00005344-199305000-00016
Publikováno v:
Hypertension. 19:668-671
Oral administration of the angiotensin II receptor subtype 1 (AT1) antagonist DuP 753 causes long-lasting lowering of mean arterial pressure in spontaneously hypertensive rats. We examined whether the antihypertensive action of DuP 753 is a result of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bad54e95f318112652776ade10165e
https://doi.org/10.1161/01.hyp.19.6.668
https://doi.org/10.1161/01.hyp.19.6.668
Autor:
Peter J. Oates, John P. Hakkinen, William F. Holt, William R. Murphy, Lawrence A. Reiter, James J. Maciejko, Goddard Carl Joseph
Publikováno v:
Digestive Diseases and Sciences. 36:1721-1728
CP-66,948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties. The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c249be3f95af077dd0a9b4907fa6765
https://doi.org/10.1007/bf01296616
https://doi.org/10.1007/bf01296616
Publikováno v:
Journal of Medicinal Chemistry. 33:543-552
A series of 4-substituted 2-guanidinothiazoles has been found to inhibit the gastric proton-pump enzyme H+,K(+)-ATPase. In general, these compounds were reversible inhibitors of canine gastric H+,K(+)-ATPase, competitive at the K+ site, and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd00287b86c0c75c1ebc5a1f9c35136
https://doi.org/10.1021/jm00164a012
https://doi.org/10.1021/jm00164a012