Zobrazeno 1 - 10
of 17
pro vyhledávání: '"William F. Heath"'
Publikováno v:
Scopus-Elsevier
The deprotection of S-4-methylbenzyl-cysteine in HF was studied as a function of acidity and scavengers employed and a highly effective procedure was developed. Under conditions of low acidity which promote SN2 deprotection of benzyl alcohol-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b21462989d81399d7655a8bb04e0671
https://doi.org/10.1111/j.1399-3011.1986.tb03284.x
https://doi.org/10.1111/j.1399-3011.1986.tb03284.x
Autor:
S.E. Bursell, George L. King, Toyoshi Inoguchi, Teruo Shiba, William F. Heath, J. R. Sportsman
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 265:E783-E793
The increases in diacylglycerol (DAG) level and protein kinase C (PKC) activity have been characterized biochemically and functionally in the retina and the brain of diabetic rats as well as in cultured vascular cells. PKC specific activities were in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a748b0fa9468bdde3a9118e4efa326d4
https://doi.org/10.1152/ajpendo.1993.265.5.e783
https://doi.org/10.1152/ajpendo.1993.265.5.e783
Publikováno v:
Proceedings of the National Academy of Sciences. 89:11059-11063
In the present study, we have measured protein kinase C (PKC) specific activities and total diacylglycerol (DAG) level in the aorta and heart of rats, which showed that after 2 weeks of streptozotocin (STZ)-induced diabetes, membranous PKC specific a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2a0cc15218e83420019ac8cfcffd13
https://doi.org/10.1073/pnas.89.22.11059
https://doi.org/10.1073/pnas.89.22.11059
Autor:
Edward P. Feener, Hidehiro Ishii, Chikako Takagi, Stramm Lawrence E, Timothy S. Kern, S-E Bursell, Allen C. Clermont, P Xia, George L. King, Daisuke Koya, William F. Heath, Jirousek, Lawrence M. Ballas
Publikováno v:
Science (New York, N.Y.). 272(5262)
The vascular complications of diabetes mellitus have been correlated with enhanced activation of protein kinase C (PKC). LY333531, a specific inhibitor of the beta isoform of PKC, was synthesized and was shown to be a competitive reversible inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49550c15d48e8f9e0e288264536b6822
https://pubmed.ncbi.nlm.nih.gov/8614830
https://pubmed.ncbi.nlm.nih.gov/8614830
Autor:
Harlan B. Long, Rama M. Belagaje, Gerald S. Brooke, Ronald E. Chance, Richard D. DiMarchi, James A. Hoffmann, Steven G. Reams, Carolyn Roundtree, Walter N. Shaw, Lawrence J. Slieker, Karen L. Sundell, William F. Heath
Publikováno v:
Peptides ISBN: 9789401050050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f2834c2d116f801ede3ddd3aaeba81
https://doi.org/10.1007/978-94-011-2264-1_29
https://doi.org/10.1007/978-94-011-2264-1_29
Publikováno v:
Peptides 1990 ISBN: 9789072199089
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc181352707d9312eeae70b334b2aee
https://doi.org/10.1007/978-94-011-3034-9_299
https://doi.org/10.1007/978-94-011-3034-9_299
Publikováno v:
Tetrahedron Letters. 23:2939-2942
The reduction of methionine sulfoxide residues in peptides was found to be quantitative by treatment with a low concentration of HF in dimethylsulfide (HF:dimethylsulfide, 1:3, v/v). The reduction was dependent on the acidity function of HF and was o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::921b4b58789d05c66c50ca34c1ca2077
https://doi.org/10.1016/s0040-4039(00)87499-7
https://doi.org/10.1016/s0040-4039(00)87499-7
Publikováno v:
Tetrahedron Letters. 23:4435-4438
The use of a low-concentration HF in dimethylsulfide (1:3, v/v) for the removal of protecting groups from synthetic peptides has been found to be efficient and to eliminate several side reactions associated with the high-concentration HF in anisole (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e204b213bda008aea426b229c87eacaf
https://doi.org/10.1016/s0040-4039(00)85621-x
https://doi.org/10.1016/s0040-4039(00)85621-x
Publikováno v:
Journal of the American Chemical Society. 105:6442-6455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1298e7137d44d1e514c23347f67df607
https://doi.org/10.1021/ja00359a014
https://doi.org/10.1021/ja00359a014
Autor:
R. B. Merrifield, William F. Heath
Publikováno v:
Proceedings of the National Academy of Sciences. 83:6367-6371
Murine epidermal growth factor, a 53-amino acid peptide that is mitogenic for a number of cell types, has been synthesized by the solid-phase method. The synthetic peptide is identical to the natural material in amino acid composition, chromatographi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad52c5606758048244b36774825b3a0e
https://doi.org/10.1073/pnas.83.17.6367
https://doi.org/10.1073/pnas.83.17.6367