Zobrazeno 1 - 10
of 37
pro vyhledávání: '"William F. Ebling"'
Autor:
William F. Ebling, Dietmar A. Seiffert, Henry J. Pieniaszek, Yu Chen Barrett, Jeffrey T. Billheimer
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 44:938-946
Thrombocytopenia exposes patients to increased bleeding risk. This serious adverse event was observed with a frequency of approximately 2% in early clinical trials with the potent, orally bioavailable glycoprotein (GP) IIb/IIIa receptor antagonist ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328c6153b56491b61d63cf84d37888d6
https://doi.org/10.1016/j.jpba.2007.03.030
https://doi.org/10.1016/j.jpba.2007.03.030
Autor:
Foster Brown, William F. Ebling, Shaker A. Mousa, Ram Kapil, Thomas M. Reilly, Patricia K. Padovani, Henry J. Pieniaszek, Jun Yu, Jeffrey S. Barrett, Jeffrey M. Bozarth, Martha H. Corjay
Publikováno v:
Biopharmaceutics & Drug Disposition. 20:309-318
The disposition of XV459, a potent, selective GP IIb/IIIa antagonist, has been examined following intravenous administration of XP280, the benzenesulphonate salt, and 3H-SA202, the trifluroacetic acid salt, to male guinea pigs. A liquid chromatograph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98589126443bc34ceae901e5a5b625f
https://doi.org/10.1002/(sici)1099-081x(199909)20:6<309::aid-bdd190>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199909)20:6<309::aid-bdd190>3.0.co
Publikováno v:
Journal of Pharmaceutical Sciences. 87:1577-1584
A precursor-dependent model of indirect pharmacody-namic response which can describe tolerance and rebound was characterized in terms of the effects of changes in the fundamental properties of the drug on its response profiles. The model extends prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ed3626e8fddf680d39730d470bdff4
https://doi.org/10.1021/js980171q
https://doi.org/10.1021/js980171q
Autor:
Sandeep Dutta, William F. Ebling
Publikováno v:
Anesthesiology. 89:678-685
Background Propofol when administered by brief infusion in a lipid-free formulation has a slower onset, prolonged offset and greater potency compared with an emulsion formulation. To understand these findings the authors examined propofol brain and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e198ac8a366ffa19c7c315480f1c68c
https://doi.org/10.1097/00000542-199809000-00018
https://doi.org/10.1097/00000542-199809000-00018
Publikováno v:
Biopharmaceutics & Drug Disposition. 18:711-716
Currently available software for nonlinear regression does not account for errors in both the independent and the dependent variables. In pharmacodynamics, measurement errors are involved in the drug concentrations as well as in the effects. Instead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::239b271a82d20aebead591d582f77362
https://doi.org/10.1002/(sici)1099-081x(199711)18:8<711::aid-bdd55>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199711)18:8<711::aid-bdd55>3.0.co
Autor:
William F. Ebling, Sandeep Dutta
Publikováno v:
Journal of Pharmaceutical Sciences. 86:44-51
Pharmacodynamics of general anesthetic agents generally exhibit biphasic concentration–effect relationships (i.e., an activation phase at low concentrations and inhibition at higher concentrations). These relationships are usually characterized wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28532f082aad56ffb19cc79c0a5d87af
https://doi.org/10.1021/js960248f
https://doi.org/10.1021/js960248f
Publikováno v:
Journal of Pharmaceutical Sciences. 86:37-43
Propofol is a unique highly lipid-soluble anesthetic that is formulated in a fat emulsion (Diprivan) for intravenous (i.v.) use. It has the desirable properties of rapid onset and offset of effect following rapid i.v. administration and minimal accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fee5df2ab9515f204d5fc2b9496d83e
https://doi.org/10.1021/js960247n
https://doi.org/10.1021/js960247n
Publikováno v:
Anesthesiology. 84:596-604
Background The goal of this investigation was to characterize the effects of thiopental on cardia output and regional blood flows in the rat. Blood flows influence thiopental pharmacokinetics. Acquisition of these data may ultimately permit evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be651a63cd71224858bbb69b710f9a4b
https://doi.org/10.1097/00000542-199603000-00015
https://doi.org/10.1097/00000542-199603000-00015
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 23:5-8
The article by Verotta and Sheiner (1) provides a cogent extension of the indirect response models (IRM) of Dayneka et al. (2) to accommodate a linear "effect compartment" as a biophase for the drug and a nonlinear transformation of an endogenous med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549e9e7499fe8f87c69290ce726ce934
https://doi.org/10.1007/bf02353781
https://doi.org/10.1007/bf02353781
Autor:
Lars L. Gustafsson, Donald R. Stanski, William F. Ebling, Sandy Harapat, Eileen Osaki, Steven L. Shafer
Publikováno v:
Pharmaceutical Research. :800-807
We have developed a computer-controlled infusion pump to achieve rapidly and then maintain stable plasma thiopental concentrations in rats. Initially we derived the parameters of a triexponential pharma-cokinetic model for thiopental, administered as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c53290b4d09eebf9921246dbb2402f4
https://doi.org/10.1023/a:1015863824277
https://doi.org/10.1023/a:1015863824277