Zobrazeno 1 - 10
of 86
pro vyhledávání: '"William F. Dietrich"'
Autor:
Eloy D. Hernandez, Lianxing Zheng, Young Kim, Bin Fang, Bo Liu, Reginald A. Valdez, William F. Dietrich, Paul V. Rucker, Donatella Chianelli, James Schmeits, Dingjiu Bao, Jocelyn Zoll, Claire Dubois, Glenn C. Federe, Lihao Chen, Sean B. Joseph, Lloyd B. Klickstein, John Walker, Valentina Molteni, Peter McNamara, Shelly Meeusen, David C. Tully, Michael K. Badman, Jie Xu, Bryan Laffitte
Publikováno v:
Hepatology Communications, Vol 3, Iss 8, Pp 1085-1097 (2019)
Farnesoid X receptor (FXR) agonism is emerging as an important potential therapeutic mechanism of action for multiple chronic liver diseases. The bile acid‐derived FXR agonist obeticholic acid (OCA) has shown promise in a phase 2 study in patients
Externí odkaz:
https://doaj.org/article/f910e104a218414a82b33320fcf44859
Autor:
Florian Nigsch, Rocco Falchetto, Nicolau Beckmann, Guglielmo Roma, Iwona Ksiazek, William F. Dietrich, Marie Jourdain, Delphine Weber, Pauline Bringer, Arun J. Sanyal, Berangere Gapp, Benjamin Kueng, Stefan Zurbruegg, Judith Knehr, Reginald Valdez, Arnaud Osmont
Publikováno v:
Hepatology Communications, Vol 4, Iss 1, Pp 109-125 (2020)
A promising approach for the treatment of nonalcoholic steatohepatitis (NASH) is the inhibition of enhanced hepatic de novo lipogenesis (DNL), which is the synthesis of fatty acids from nonlipid sources. This study assesses three approaches to DNL su
Autor:
Natalie Dales, Monish Jain, Sanchez Carina Cristina, Ryan Kerrigan, Atwood K. Cheung, Cary Fridrich, Donovan N. Chin, Brian Hurley, Keith Hoffmaster, Lin Deng, Ronald Tomlinson, Marc Hild, Rajeev Sivasankaran, Jake Axford, Aleem Fazal, Gary O’Brien, Christopher Towler, Mailin Van Hoosear, Youngah Shin, Dione Kobayashi, Shen Yiping, Lei Shu, William F. Dietrich, Karen S. Chen, Lawrence G. Hamann, Karin Briner, Rebecca Servais, Cheng Song, Emma Cody, Robert Sun, Daniel Curtis, Moo Je Sung, Ying Hou
Publikováno v:
Journal of Medicinal Chemistry. 61:11021-11036
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a loss of function mutation of the survival motor neuron 1 (SMN1) gene. In humans, a second
Autor:
Delphine Weber, William F. Dietrich, Lilly von Muenchow, Benjamin Kueng, Jiri Kovarik, Thomas Le Meur, Iwona Ksiazek, Berangere Gapp, Antonius G. Rolink, Munkyung Kim
Publikováno v:
Immunology Letters. 198:60-65
Dipeptidyl peptidase 9 (DPP9) is a ubiquitously expressed intracellular prolyl peptidase implicated in immunoregulation. However, its physiological relevance in the immune system remains largely unknown. We investigated the role of DPP9 enzyme in imm
Autor:
Berangere Gapp, Iwona Ksiazek, Corinne Haller, Johann Wirsching, Kenji Namoto, Filippo M. Rijli, Alessandro Piaia, Delphine Weber, Benjamin Kueng, William F. Dietrich, Frederic Bassilana, Samuel Barbieri, Munkyung Kim, Thorsten Lorenz, Maryline Minoux
Publikováno v:
Developmental Biology. 431:297-308
Dipeptidyl peptidase 9 (DPP9) is an intracellular N-terminal post-proline-cleaving enzyme whose physiological function remains largely unknown. We investigated the role of DPP9 enzyme in vivo by characterizing knock-in mice expressing a catalytically
Autor:
Peter McNamara, Jocelyn Zoll, Lianxing Zheng, Shelly Meeusen, Young Kim, Glenn C. Federe, Lihao Chen, Eloy D. Hernandez, John R. Walker, Dingjiu Bao, Lloyd B. Klickstein, William F. Dietrich, Paul Vincent Rucker, Valentina Molteni, Bin Fang, Reginald Valdez, Sean B. Joseph, Bo Liu, James Schmeits, Claire Dubois, Chianelli Donatella, Michael Badman, David C. Tully, Bryan Laffitte, Jie Xu
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 8, Pp 1085-1097 (2019)
Hepatology Communications, Vol 3, Iss 8, Pp 1085-1097 (2019)
Farnesoid X receptor (FXR) agonism is emerging as an important potential therapeutic mechanism of action for multiple chronic liver diseases. The bile acid‐derived FXR agonist obeticholic acid (OCA) has shown promise in a phase 2 study in patients
Autor:
Osku Raukunen, Urs Ganse, Norma Crosby, A. J. Tylka, William F. Dietrich, Robert Siipola, Rami Vainio, D. Heynderickx, Mark Dierckxsens, Piers Jiggens
Publikováno v:
Journal of Space Weather and Space Climate, Vol 8, p A04 (2018)
Solar energetic particles (SEPs) constitute an important component of the radiation environment in interplanetary space. Accurate modeling of SEP events is crucial for the mitigation of radiation hazards in spacecraft design. In this study we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5553768c482ac704636b712da60a7aee
http://hdl.handle.net/10138/232158
http://hdl.handle.net/10138/232158
Autor:
Xiaolu Zhang, Jeffery A. Porter, Atwood K. Cheung, Vic E. Myer, Mark C. Fishman, Caroline Gubser Keller, Rajeev Sivasankaran, John A. Tallarico, Marc Hild, Sven Schuierer, Michael McLellan, Frada Berenshteyn, William F. Dietrich, Cecile Blaustein, Youngah Shin, Lei Shu, Michael Salcius, Monish Jain, Mailin Van Hoosear, Donovan N. Chin, Arnaud Lacoste, Martin Beibel, James Palacino, Nicole A. Renaud, Leo Murphy, Marcel J. J. Blommers, Lawrence G. Hamann, Caroline Bullock, Xiaoying Shi, Lin Deng, Jason R. Thomas, Daniel Curtis, Thomas M. Smith, Susanne E. Swalley, Gregory A. Michaud, Cheng Song, Brian Tseng, Guglielmo Roma, Natalie Dales, Rebecca Servais
Publikováno v:
Nature Chemical Biology. 11:511-517
Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric mortality. A duplicate copy (SMN2) is inefficiently spliced, producing a tru
Publikováno v:
Astronomy & Astrophysics
Aims. The aim of the study is to investigate the reason for the low productivity of high-energy SEPs in the present solar cycle.Methods. We employ scaling laws derived from diffusive shock acceleration theory and simulation studies including proton-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11cc8bd26029c3e18f6a41b5b468aad
Publikováno v:
Proceedings of The 34th International Cosmic Ray Conference — PoS(ICRC2015).