Zobrazeno 1 - 10
of 56
pro vyhledávání: '"William F. Carson"'
Autor:
Michael Sorkin, Amanda K. Huber, Charles Hwang, William F. Carson, Rajasree Menon, John Li, Kaetlin Vasquez, Chase Pagani, Nicole Patel, Shuli Li, Noelle D. Visser, Yashar Niknafs, Shawn Loder, Melissa Scola, Dylan Nycz, Katherine Gallagher, Laurie K. McCauley, Jiajia Xu, Aaron W. James, Shailesh Agarwal, Stephen Kunkel, Yuji Mishina, Benjamin Levi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages
Externí odkaz:
https://doaj.org/article/d1da08c830104fc9b81a6525ff7ff86b
Autor:
Shailesh Agarwal, Shawn J. Loder, David Cholok, John Li, Guowu Bian, Srilakshmi Yalavarthi, Shuli Li, William F. Carson, Charles Hwang, Simone Marini, Chase Pagani, Nicole Edwards, Matthew J. Delano, Theodore J. Standiford, Jason S. Knight, Steven L. Kunkel, Yuji Mishina, Peter A. Ward, Benjamin Levi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated
Externí odkaz:
https://doaj.org/article/2677d734533846c3970bc16d46f04165
Autor:
Andrew S. Kimball, Amrita D. Joshi, Anna E. Boniakowski, Matthew Schaller, Jooho Chung, Ronald Allen, Jennifer Bermick, William F. Carson, Peter K. Henke, Ivan Maillard, Steve L. Kunkel, Katherine A. Gallagher
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Macrophages are essential immune cells necessary for regulated inflammation during wound healing. Recent studies have identified that Notch plays a role in macrophage-mediated inflammation. Thus, we investigated the role of Notch signaling on wound m
Externí odkaz:
https://doaj.org/article/35f434592d4c46f09af8db6f9444a60f
Autor:
Samantha Ottinger, Pearl Bakhru, Hsin-Jung Wu, Wilson Guzman, Michael Ophir, Michael March Schmidt, Leung Cheuk Lun, Nora Zizlsperger, Chao Wang, Ana C. Anderson, Robert Tighe, Sunny Q. He, Piotr Bobrowicz, Dana C. Gilmore, Conner Lambden, Benjamin Wolf, Lucy Liu, Jason Lajoie, Christine Cummings, William K. McConaughy, Thomas Joseph Schuetz, Ugur Eskiocak, William F. Carson, Lauren Milling
Publikováno v:
JCI Insight. 5
CD137 (4-1BB) is a member of the TNFR superfamily that represents a promising target for cancer immunotherapy. Recent insights into the function of TNFR agonist antibodies implicate epitope, affinity, and IgG subclass as critical features, and these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528666204f4a950748d3cb0a61422930
https://doi.org/10.1172/jci.insight.133647
https://doi.org/10.1172/jci.insight.133647
Autor:
Shawn Loder, Amanda K. Huber, John Li, Yuji Mishina, Dylan Nycz, Yashar S. Niknafs, S L Kunkel, William F. Carson, Michael Sorkin, Rajasree Menon, Kaetlin Vasquez, Aaron W. James, Laurie K. McCauley, Shuli Li, Chase A. Pagani, Noelle D. Visser, Melissa Scola, Shailesh Agarwal, Charles Hwang, Nicole Patel, Katherine A. Gallagher, Jiajia Xu, Benjamin Levi
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in response to musculoskeletal trauma, in which mesenchymal stem cells (MSC) differentiate into osteochondrogenic cells instead of myocytes or tenocytes. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45de80ca27aa0a22a704898f6675c545
http://europepmc.org/articles/PMC7002453
http://europepmc.org/articles/PMC7002453
Autor:
Dylan Nycz, Noelle D. Visser, Aaron W. James, Katherine A. Gallagher, Shuli Li, Kaetlin Vasquez, Laurie K. McCauley, Yashar S. Niknafs, Melissa Scola, Charles Hwang, Amanda K. Huber, Shailesh Agarwal, Chase A. Pagani, Yuji Mishina, Nicole Patel, William F. Carson, Rajasree Menon, Michael Sorkin, Benjamin Levi, Jiajia Xu, S L Kunkel, Shawn Loder, John Li
Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in response to musculoskeletal trauma, in which mesenchymal stem cells (MSC) differentiate into osteochondrogenic cells instead of myocytes or tenocytes. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c27e44fcd118bae1f9131f4cabb36a
https://doi.org/10.1101/871574
https://doi.org/10.1101/871574
Autor:
Frank M. Davis, Charles F. Burant, Anna Boniakowski, Ronald M. Allen, Peter K. Henke, Matthew Schaller, Amrita Joshi, Steve Kunkel, Katherine A. Gallagher, Jennifer Bermick, Andrew Kimball, William F. Carson
Publikováno v:
Diabetes
Macrophages are critical for the initiation and resolution of the inflammatory phase of wound repair. In diabetes, macrophages display a prolonged inflammatory phenotype in late wound healing. Mixed-lineage leukemia-1 (MLL1) has been shown to direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f34670a0b3e25ebeff00825978acbd5
http://europepmc.org/articles/PMC5566299
http://europepmc.org/articles/PMC5566299
Autor:
Shawn Loder, John Li, Charles Hwang, William F. Carson, Nicole J. Edwards, Srilakshmi Yalavarthi, Jason S. Knight, David Cholok, Shailesh Agarwal, Simone Marini, Guowu Bian, Peter A. Ward, Benjamin Levi, Theodore J. Standiford, Yuji Mishina, Chase A. Pagani, Shuli Li, Steven L. Kunkel, Matthew J. Delano
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22af1bff27033999052272337921c783
https://www.frontiersin.org/article/10.3389/fimmu.2019.02148/full
https://www.frontiersin.org/article/10.3389/fimmu.2019.02148/full
Autor:
Nicholas W. Lukacs, Matthew Schaller, Jennifer Bermick, Nathalie J Lambrecht, William F. Carson, Kathryn R Michels
Publikováno v:
J Infect Dis
Sepsis from Escherichia coli expressing the K1 antigen is a leading cause of death in neonates. In a murine model, E. coli K1 grew rapidly in the peritoneal cavity of neonatal mice, causing fatal disease. In contrast, adult mice cleared the infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596a5f429b4be11eaf0aeb92a9fef5f9
https://pubmed.ncbi.nlm.nih.gov/31136646
https://pubmed.ncbi.nlm.nih.gov/31136646
Autor:
Jan P. Stegemann, Steven L. Kunkel, Ramkumar T. Annamalai, Benjamin Levi, William F. Carson, Paul A. Turner
Biomaterials-based approaches to harnessing the immune and inflammatory responses to potentiate wound healing hold important promise. Bone fracture healing is characterized by an acute inflammatory phase, followed by a transition to a regenerative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9b6d647d6efb574a3e2a948c8439e1
https://europepmc.org/articles/PMC5831261/
https://europepmc.org/articles/PMC5831261/