Zobrazeno 1 - 10
of 141
pro vyhledávání: '"William F. Blakemore"'
Publikováno v:
Cell Transplantation, Vol 9 (2000)
Persistent demyelination, in addition to being the major pathology of multiple sclerosis and the leucodystrophies, is also a feature of spinal cord trauma where there is evidence that it contributes to the functional deficit. In experimental animals
Externí odkaz:
https://doaj.org/article/0444ba39cbb44ed9b0ef41d6c3a40f88
Autor:
C. M. H. Brierley, Yasushi Iwashita, Jennifer M. Gilson, D. A. S. Compston, A. J. Crang, Neil J Scolding, William F. Blakemore
Publikováno v:
Cell Transplantation, Vol 10 (2001)
Areas of demyelination can be remyelinated by transplanting myelin-forming cells. Schwann cells are the naturally remyelinating cells of the peripheral nervous system and have a number of features that may make them attractive for cell implantation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f5599b75068864282e5f8214997cac
https://pubmed.ncbi.nlm.nih.gov/28866942
https://pubmed.ncbi.nlm.nih.gov/28866942
Publikováno v:
Journal of the Neurological Sciences. 265:43-46
The relative merits of endogenous and exogenous oligodendrocyte progenitor cells (OPCs) for remyelination are compared in terms of their ability to repopulate OPC-depleted tissue and generate remyelinating oligodendrocytes. Exogenous neonatal OPCs ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f13908bbdd16182e12a3b8b203f1069
https://doi.org/10.1016/j.jns.2007.08.004
https://doi.org/10.1016/j.jns.2007.08.004
Autor:
Anne Elizabeth Rosser, Alastair Compston, William F. Blakemore, Siddharthan Chandran, Maeve A. Caldwell, Karen-Amanda Irvine, Colin Watts, Daniel J. Webber, Nicholas D. Allen, Alexis J Joannides, Claire Kelly, Olivier Raineteau, Paul J. Kemp
Publikováno v:
Brain. 130:1263-1275
Human embryonic stem cells (hESCs) are a potential source of defined tissue for cell-based therapies in regenerative neurology. In order for this potential to be realized, there is a need for the evaluation of the behaviour of human embryonic stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea1575934086d64e526fe9655b99dc8
https://doi.org/10.1093/brain/awm070
https://doi.org/10.1093/brain/awm070
Publikováno v:
Journal of Neuroimmunology. 175:69-76
Axon loss is recognised as a significant contributor to the progression of the disability associated with multiple sclerosis. Although evidence of axon damage is found in areas of chronic demyelination it is more frequently seen in association with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d951e8f4404d887b6ab535f322bd7d
https://doi.org/10.1016/j.jneuroim.2006.03.002
https://doi.org/10.1016/j.jneuroim.2006.03.002
Publikováno v:
Brain Pathol
While the effects of high dose X-irradiation on mitotically active progenitor cells and remyelination are well-documented, its effects on myelinating oligodendrocytes are less clear, due in part to divergent views on their mitotic capacity. To examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8e651bc7902f1ea39ea7e4b6cdf595
https://doi.org/10.1111/j.1750-3639.2002.tb00463.x
https://doi.org/10.1111/j.1750-3639.2002.tb00463.x
Publikováno v:
Experimental Neurology. 184:955-963
To date, most experiments examining the myelination potential of transplanted cells have been undertaken into either the immature nervous system or into acutely demyelinating lesions. Since these are situations where myelination or remyelination are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2de8d87626f2ab9d37e1939ffc2e6a
https://doi.org/10.1016/s0014-4886(03)00347-9
https://doi.org/10.1016/s0014-4886(03)00347-9
Publikováno v:
Journal of Neuroscience Research. 73:787-793
We have attempted to extend a previously described rat model of focal oligodendrocyte progenitor cell (OPC) depletion, using 40 Gy X-irradiation (Chari and Blakemore [2002] Glia 37:307-313), to the adult mouse spinal cord, to examine the ability of O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1bd4187ab4cb6215089450473b9b19
https://doi.org/10.1002/jnr.10700
https://doi.org/10.1002/jnr.10700
Publikováno v:
Journal of Neuroimmunology
Using a passively transferred acute model of experimental allergic encephalomyelitis (EAE) in the rat, inflammatory central nervous system (CNS) lesions were shown to develop rapidly, peak and then resolve. An unusual feature of the lesions in the CN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc277135abeec4cd7b7e17ecd30644a3
http://europepmc.org/articles/PMC7119869
http://europepmc.org/articles/PMC7119869
Autor:
Divya M. Chari, William F. Blakemore
Publikováno v:
Glia. 37:307-313
A widely quoted hypothesis for the failure of remyelination in multiple sclerosis (MS) is the exhaustion of the oligodendrocyte progenitor cell (OPC) pool that is strongly implicated as the source of remyelinating oligodendrocytes in demyelinating le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e380384c6877da3caa66e0d35db2545c
https://doi.org/10.1002/glia.10038
https://doi.org/10.1002/glia.10038