Zobrazeno 1 - 10
of 96
pro vyhledávání: '"William F Forrest"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009131 (2021)
Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. However, association studies involving immunogenetic loci most commonly involve simple analyses of
Externí odkaz:
https://doaj.org/article/eb1deaaeb2a8463897dfba4588dedffb
Autor:
Diana Chang, Julie Hunkapiller, Tushar Bhangale, Jens Reeder, Kiran Mukhyala, Jennifer Tom, Amy Cowgill, Jan Vogel, William F. Forrest, Zia Khan, Amy Stockwell, Mark I. McCarthy, Tracy L. Staton, Julie Olsson, Cecile T. J. Holweg, Dorothy S. Cheung, Hubert Chen, Matthew J. Brauer, Robert R. Graham, Timothy Behrens, Mark S. Wilson, Joseph R. Arron, David F. Choy, Brian L. Yaspan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics underlying moderate-to-severe asthma risk. Here, we present a whole-genome sequen
Externí odkaz:
https://doaj.org/article/5fa4592260184e79882d694bb0b47a44
Autor:
John C. Tran, Thomas Hunsaker, Christina Bell, Taylur P. Ma, Emily Chan, Pablo Saenz-Lopez Larrocha, Kelsey Homyk, Liling Liu, Hank La, Jialin Mao, Cecile C. de la Cruz, Kebing Yu, Maureen Beresini, William F. Forrest, Yang Xiao, Anne Jang, Natalia Samus, Nicholas Dupuis Stesco, Marija Mentinova, Stephane Parent, Gwenael Pottiez, Michael Schirm, Hans E. Purkey, Yichin Liu, Mark Merchant
Publikováno v:
Analytical Chemistry. 95:4834-4839
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea38580cf5f1df5004a2b5d1c9e5ae9
https://doi.org/10.1021/acs.analchem.2c04417
https://doi.org/10.1021/acs.analchem.2c04417
Autor:
Jean-Philippe Fortin, Jenille Tan, Karen E. Gascoigne, Peter M. Haverty, William F. Forrest, Michael R. Costa, Scott E. Martin
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-25 (2019)
Abstract Background Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While several studies have focused on correcting for DNA cleavage toxicity biases associated with copy
Externí odkaz:
https://doaj.org/article/da41017688c44f37813cd692b3acf27a
Autor:
Jennifer A. Tom, Jens Reeder, William F. Forrest, Robert R. Graham, Julie Hunkapiller, Timothy W. Behrens, Tushar R. Bhangale
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Large sample sets of whole genome sequencing with deep coverage are being generated, however assembling datasets from different sources inevitably introduces batch effects. These batch effects are not well understood and can be du
Externí odkaz:
https://doaj.org/article/cd005446c0714a70933f7fb8a1664523
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
RTK activity plays a key role in regulating p110a degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3f61f91c6eba4539d57e9ffe438944
https://doi.org/10.1158/2159-8290.22540279
https://doi.org/10.1158/2159-8290.22540279
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
PIK3CA is one of the most frequently mutated oncogenes; the p110a protein it encodes plays a central role in tumor cell proliferation. Small-molecule inhibitors targeting the PI3K p110a catalytic subunit have entered clinical trials, with early-phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd67c192262a4b6f3e1d058d9266830
https://doi.org/10.1158/2159-8290.c.6549343
https://doi.org/10.1158/2159-8290.c.6549343
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric mitogen-activated protein/extracellular signal–regulated kinase (MEK) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07be02e8e9258d59fd0d5344faa763ab
https://doi.org/10.1158/1535-7163.c.6535320.v1
https://doi.org/10.1158/1535-7163.c.6535320.v1
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
PDF file - 451K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3923262ef522e46408ad2b4fe9b478f6
https://doi.org/10.1158/1535-7163.22496553
https://doi.org/10.1158/1535-7163.22496553
Autor:
Ron Firestein, William F. Forrest, Erica Jackson, David Shames, Li Li, Janet Tao, Margaret Solon, Elizabeth M. Blackwood, Leslie Lee, Ely Cosino, Laura Deming, Adam S. Adler, Mark L. McCleland
Purpose: This study is aimed to identify genes within the KRAS genomic amplicon that are both coupregulated and essential for cell proliferation when KRAS is amplified in lung cancer.Experimental Design: We used an integrated genomic approach to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21add0973b931e45711f893e0e29032b
https://doi.org/10.1158/1078-0432.c.6521406
https://doi.org/10.1158/1078-0432.c.6521406