Zobrazeno 1 - 10
of 247
pro vyhledávání: '"William F Elmquist"'
Autor:
Cecile Riviere-Cazaux, Karishma Rajani, Masum Rahman, Juhee Oh, Desmond A. Brown, Jaclyn F. White, Benjamin T. Himes, Ignacio Jusue-Torres, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, William F. Elmquist, Terry C. Burns
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas. Gliomas are mainly accessible at the time of sur
Externí odkaz:
https://doaj.org/article/b01726b9a3c24b95811a6ea5c664f995
Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Karishma Rajani, Amanda Munoz-Casabella, Masum Rahman, Ali Gharibi-Loron, Desmond A. Brown, Kai J. Miller, Jaclyn J. White, Benjamin T. Himes, Ignacio Jusue-Torres, Samar Ikram, Seth C. Ransom, Renee Hirte, Ju-Hee Oh, William F. Elmquist, Jann N. Sarkaria, Rachael A. Vaubel, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, Terry C. Burns
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The extracellular microenvironment modulates glioma behaviour. It remains unknown if blood-brain barrier disruption merely reflects or functionally supports glioma aggressiveness. We utilised intra-operative microdialysis to sample the extra
Externí odkaz:
https://doaj.org/article/df7819129fee4a19804cd898e7b157b6
Autor:
Brianna M. Holder, Shaina E. Tolan, Kaleb K. Heinrich, Kaitlin C. Miller, Natalie Hudson, Geetika Nehra, Michelle E. Pizzo, Steffen E. Storck, William F. Elmquist, Britta Engelhardt, Irena Loryan, Michal Toborek, Bjoern Bauer, Anika M. S. Hartz, Brandon J. Kim
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field, several international conferences exist that allow researchers to present d
Externí odkaz:
https://doaj.org/article/9b52a93633bb43e6822fea744263dc65
Autor:
Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy, Minjee Kim, Alison Roos, David Calligaris, Michael S. Regan, Shiv K. Gupta, Ann C. Mladek, Brett L. Carlson, Aaron J. Johnson, Fa-Ke Lu, X. Sunney Xie, Brian A. Joughin, Raven J. Reddy, Sen Peng, Walid M. Abdelmoula, Pamela R. Jackson, Aarti Kolluri, Katherine A. Kellersberger, Jeffrey N. Agar, Douglas A. Lauffenburger, Kristin R. Swanson, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y. R. Agar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib,
Externí odkaz:
https://doaj.org/article/17219987055045cbbd74e20d4356a523
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:44-55
Important challenges in developing drugs that target central nervous system (CNS) tumors include overcoming barriers for CNS delivery and reducing systemic side effects. Alisertib, an aurora A kinase inhibitor, has been examined for treatment of seve
Autor:
Jason E Conage-Pough, Sylwia A Stopka, Ju-Hee Oh, Ann C Mladek, Danielle M Burgenske, Michael S Regan, Gerard Baquer, Paul A Decker, Brett L Carlson, Katrina K Bakken, Jinqiang Zhang, Lily Liu, Claire Sun, Zhihua Mu, Wei Zhong, Nhan L Tran, William F Elmquist, Nathalie Y R Agar, Jann N Sarkaria, Forest M White
Publikováno v:
Neuro-Oncology Advances.
Background Although the epidermal growth factor receptor (EGFR) is a frequent oncogenic driver in glioblastoma (GBM), efforts to therapeutically target this protein have been largely unsuccessful. The present pre-clinical study evaluated the novel EG
Autor:
Jann N. Sarkaria, William F. Elmquist, Andrew A. Protter, Ying Feng, Yuqiao Shen, Gaspar J. Kitange, Paul A. Decker, Mark A. Schroeder, Ann C. Mladek, Katrina K. Bakken, Brett L. Carlson, Karen E. Parrish, Ryo Kawashima, Kenneth Chang, Shiv K. Gupta, Sani H. Kizilbash
Evaluation of sensitizing effects of TAL in GBM cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37be1fdfda968d46ee4b4d22cb01bc32
https://doi.org/10.1158/1535-7163.22505305.v1
https://doi.org/10.1158/1535-7163.22505305.v1
Autor:
Oren J. Becher, William F. Elmquist, Guo Hu, Kyle G. Halvorson, Donna Crabtree, Karen E. Parrish, Alexander H. Chung, Rajendar K. Mittapalli
Representative images of four dasatinib-treated murine brainstem gliomas in ABC KO and ABC WT mice (10X and 40X images).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a8ad2fc66d6ca1f735d08112a992de
https://doi.org/10.1158/1535-7163.22503814
https://doi.org/10.1158/1535-7163.22503814
Autor:
John R. Ohlfest, William F. Elmquist, Jann N. Sarkaria, Jenny L. Pokorny, Karen S. SantaCruz, Stacy A. Decker, Charlie Seiler, Randy Donelson, Jose L. Gallardo, David M. Zellmer, Rajendar K. Mittapalli, Sagar Agarwal
PDF file, 71K, Pharmacokinetic Parameters in WT and TKO Mice after Oral Dosing with 15 mg/kg Dasatinib (Data presented as Mean � S.E. of Estimate).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c79962d24bcc721f0ebffc2032e87f
https://doi.org/10.1158/1535-7163.22496526.v1
https://doi.org/10.1158/1535-7163.22496526.v1
Autor:
Jann N. Sarkaria, William F. Elmquist, Andrew A. Protter, Ying Feng, Yuqiao Shen, Gaspar J. Kitange, Paul A. Decker, Mark A. Schroeder, Ann C. Mladek, Katrina K. Bakken, Brett L. Carlson, Karen E. Parrish, Ryo Kawashima, Kenneth Chang, Shiv K. Gupta, Sani H. Kizilbash
Supplementary methods and Captions to the Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1dd961369700b863b7c74aa06bee26
https://doi.org/10.1158/1535-7163.22505281.v1
https://doi.org/10.1158/1535-7163.22505281.v1