Zobrazeno 1 - 10
of 72
pro vyhledávání: '"William F, Flynn"'
Autor:
Suleyman B. Bozal, Greg Sjogren, Antonio P. Costa, Joseph S. Brown, Shannon Roberts, Dylan Baker, Paul Gabriel, Jr., Benjamin T. Ristau, Michael Samuels, William F. Flynn, Paul Robson, Elise T. Courtois
Publikováno v:
SLAS Discovery, Vol 29, Iss 7, Pp 100182- (2024)
The use of organoid models in biomedical research has grown substantially since their inception. As they gain popularity among scientists seeking more complex and biologically relevant systems, there is a direct need to expand and clarify potential u
Externí odkaz:
https://doaj.org/article/eb7fa212871d4f388d6efcd695a127e0
Autor:
Nourhan Abdelfattah, Parveen Kumar, Caiyi Wang, Jia-Shiun Leu, William F. Flynn, Ruli Gao, David S. Baskin, Kumar Pichumani, Omkar B. Ijare, Stephanie L. Wood, Suzanne Z. Powell, David L. Haviland, Brittany C. Parker Kerrigan, Frederick F. Lang, Sujit S. Prabhu, Kristin M. Huntoon, Wen Jiang, Betty Y. S. Kim, Joshy George, Kyuson Yun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Glioblastoma (GBM) is an immune cold tumour that is refractory to immunotherapy. Here, the authors identify molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and propose S100A4 as a regu
Externí odkaz:
https://doaj.org/article/8729e15cfe464e098e0bc6e28aafb086
Autor:
Colin M Cleary, Brenda M Milla, Fu-Shan Kuo, Shaun James, William F Flynn, Paul Robson, Daniel K Mulkey
Publikováno v:
eLife, Vol 10 (2021)
Glutamatergic neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating breathing in response to tissue CO2/H+. The RTN and greater parafacial region may also function as a chemosensing network composed of CO2/H
Externí odkaz:
https://doaj.org/article/a794c70933c444b69e808778ca8d0144
Autor:
Yue Zhao, Ziwei Pan, Sandeep Namburi, Andrew Pattison, Atara Posner, Shiva Balachander, Carolyn A. Paisie, Honey V Reddi, Jens Rueter, Anthony J Gill, Stephen Fox, Kanwal P.S. Raghav, William F Flynn, Richard W. Tothill, Sheng Li, R. Krishna Murthy Karuturi, Joshy George
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103030- (2020)
Background: Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer where a primary site of origin cannot be found despite a standard diagnostic workup. Because knowledge of a patient's pr
Externí odkaz:
https://doaj.org/article/2e9c24dab6e948a488ab77e4c14eacf9
Autor:
Laura E Mickelsen, William F Flynn, Kristen Springer, Lydia Wilson, Eric J Beltrami, Mohan Bolisetty, Paul Robson, Alexander C Jackson
Publikováno v:
eLife, Vol 9 (2020)
The ventral posterior hypothalamus (VPH) is an anatomically complex brain region implicated in arousal, reproduction, energy balance, and memory processing. However, neuronal cell type diversity within the VPH is poorly understood, an impediment to d
Externí odkaz:
https://doaj.org/article/f02d6e6103d34caba2ca930b33e75939
Autor:
Yuliana Tan, William F. Flynn, Santhosh Sivajothi, Diane Luo, Suleyman B. Bozal, Monica Davé, Anthony A. Luciano, Paul Robson, Danielle E. Luciano, Elise T. Courtois
Publikováno v:
Nature Cell Biology. 24:1306-1318
Autor:
Manju Sharma, Anuj Srivastava, Heather E Fairfield, David Bergstrom, William F Flynn, Robert E Braun
Publikováno v:
eLife, Vol 8 (2019)
Long-term maintenance of spermatogenesis in mammals is supported by GDNF, an essential growth factor required for spermatogonial stem cell (SSC) self-renewal. Exploiting a transgenic GDNF overexpression model, which expands and normalizes the pool of
Externí odkaz:
https://doaj.org/article/ba56eebc7676437089affa7c86308975
Autor:
David A. Tuveson, Paul Robson, Andrea Califano, Elizabeth M. Jaffee, Jonathan Preall, Youngkyu Park, Christopher L. Wolfgang, Yuan Hao, Kenneth H. Yu, Dannielle D. Engle, Todd D. Armstrong, Santhosh Sivajothi, Matthew S. Lucito, Giulia Biffi, Pascal Belleau, Jonathan A. Teinor, Richard A. Burkhart, Elise T. Courtois, William F. Flynn, Pasquale Laise, Mohan Bolisetty, Ela Elyada
Supplementary Table S20 shows the marker genes of the different clusters in the fibroblast-enriched KPC analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3b6bcec656f62f607a93bd27233b87
https://doi.org/10.1158/2159-8290.22536689.v1
https://doi.org/10.1158/2159-8290.22536689.v1
Autor:
David A. Tuveson, Paul Robson, Andrea Califano, Elizabeth M. Jaffee, Jonathan Preall, Youngkyu Park, Christopher L. Wolfgang, Yuan Hao, Kenneth H. Yu, Dannielle D. Engle, Todd D. Armstrong, Santhosh Sivajothi, Matthew S. Lucito, Giulia Biffi, Pascal Belleau, Jonathan A. Teinor, Richard A. Burkhart, Elise T. Courtois, William F. Flynn, Pasquale Laise, Mohan Bolisetty, Ela Elyada
Supplementary Table S1 shows patient information, Supplementary Table S2 shows cell numbers analyzed from each human PDAC sample, Supplementary Table S3 shows statistics of the clustering analysis of the human PDAC single cell RNA sequencing, Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537a71e519160c84fb5e054e05d8c6ba
https://doi.org/10.1158/2159-8290.22536665.v1
https://doi.org/10.1158/2159-8290.22536665.v1
Autor:
David A. Tuveson, Paul Robson, Andrea Califano, Elizabeth M. Jaffee, Jonathan Preall, Youngkyu Park, Christopher L. Wolfgang, Yuan Hao, Kenneth H. Yu, Dannielle D. Engle, Todd D. Armstrong, Santhosh Sivajothi, Matthew S. Lucito, Giulia Biffi, Pascal Belleau, Jonathan A. Teinor, Richard A. Burkhart, Elise T. Courtois, William F. Flynn, Pasquale Laise, Mohan Bolisetty, Ela Elyada
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05668eed082a8964c856d8103f8ad225
https://doi.org/10.1158/2159-8290.c.6548204.v1
https://doi.org/10.1158/2159-8290.c.6548204.v1