Zobrazeno 1 - 3
of 3
pro vyhledávání: '"William Eric Frietze"'
Autor:
Santella Joseph B, John Wityak, Ruth R. Wexler, Robert A. Copeland, Pitts William J, Deborah A. Stradley, Frank W. Hobbs, Peggy Scherle, Elizabeth J. Manos, A. Christine Tabaka, Jung-Hui Sun, Kurumi Y. Horiuchi, James M. Trzaskos, William Eric Frietze, Ronald L. Magolda, Duncia John, Andrea J. Daulerio, Richard E. Olson, C. Anne Higley, Christopher A. Teleha, Richard A. Earl, F.Wayne Rankin, Margaret F. Favata, Karl F. Blom, George L. Trainor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2839-2844
In search of antiinflammatory drugs with a new mechanism of action, U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with an IC50 of 0.07 microM for MEK 1 and 0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e7239bbbcdbe88ce04a2dcd87efb1e
https://doi.org/10.1016/s0960-894x(98)00522-8
https://doi.org/10.1016/s0960-894x(98)00522-8
Autor:
David W. Robertson, Argyrios G. Arvanitis, Charles R. Arnold, William Eric Frietze, Paul J. Gilligan, Lawrence W. Fitzgerald, Richard E. Olson
Publikováno v:
ChemInform. 34
A series of imidazo[4,5-b]pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470dedb391c56ea4f6101c5b067ad117
https://doi.org/10.1002/chin.200319143
https://doi.org/10.1002/chin.200319143
Autor:
Gregory C. Houghton, Elizabeth A. Hausner, Richard E. Olson, Ruth R. Wexler, Thomas M. Reilly, Adrienne L. Racanelli, Di Meo Sv, Shaker A. Mousa, Batt Dg, Michael J. Orwat, Junke Liu, Kapil Rp, Tobin Ae, Rabel, Thais M. Sielecki, George K. Lalka, Martin Thoolen, Paul Anderson, Donald Joseph Philip Pinto, John Wityak, William Eric Frietze
Publikováno v:
Journal of medicinal chemistry. 42(7)
Modification of the alpha-carbamate substituent of isoxazoline GPIIb/IIIa (alphaIIb beta3) antagonist DMP 754 (7) led to a series of alpha-sulfonamide and alpha-sulfamide diaminopropionate isoxazolinylacetamides which were found to be potent inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e0a60d8b9b75dcef40126d4249ff7a
https://pubmed.ncbi.nlm.nih.gov/10197962
https://pubmed.ncbi.nlm.nih.gov/10197962