Zobrazeno 1 - 10
of 11
pro vyhledávání: '"William E. Wixted"'
Autor:
Caroline Richardson, Zining Wu, Henriëtte M. G. Willems, William E. Wixted, Alison Jo-Anne Woolford, Charlotte Mary Griffiths-Jones, Yolanda Sanchez, David Norton, Jeffrey K. Kerns, T.G. Davies, William G. Bonnette, Sharna J. Rich, James F. Callahan, Hong Nie, Lawrence Wolfe, Maria Grazia Carr, Marcel L. Verdonk, William L. Rumsey, Tom D. Heightman
Publikováno v:
Journal of Medicinal Chemistry. 64:15949-15972
The NRF2-mediated cytoprotective response is central to cellular homoeostasis, and there is increasing interest in developing small-molecule activators of this pathway as therapeutics for diseases involving chronic oxidative stress. The protein KEAP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba196f8cf42319174247f8aba6d5c760
https://doi.org/10.1021/acs.jmedchem.1c01351
https://doi.org/10.1021/acs.jmedchem.1c01351
Autor:
Wensheng Xie, Marie Pariollaud, William E Wixted, Nilesh Chitnis, James Fornwald, Maggie Truong, Christina Pao, Yan Liu, Robert S Ames, James Callahan, Roberto Solari, Yolanda Sanchez, Alan Diehl, Hu Li
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119738 (2015)
Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD. PERK, one branch in the ER stress signaling pathwa
Externí odkaz:
https://doaj.org/article/45880be0f2cc430391c27c8c50ecb52e
Autor:
Jen-Pyng Kou, James F. Callahan, John Yonchuk, Joseph P. Foley, Hong Nie, Heidi G. Feldser, Yolanda Sanchez, William E. Wixted, Jeffrey K. Kerns, Diana G Chalupowicz, Gregory A. Logan, Patricia L. Podolin, Brian Bolognese
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 363:114-125
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key regulator of oxidative stress and cellular repair and can be activated through inhibition of its cytoplasmic repressor, Kelch-like ECH-associated protein 1 (Keap1). Several small molecule di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::204466407cf0cd7f7f72972a187970e8
https://doi.org/10.1124/jpet.117.241794
https://doi.org/10.1124/jpet.117.241794
Autor:
John G, Yonchuk, Joseph P, Foley, Brian J, Bolognese, Gregory, Logan, William E, Wixted, Jen-Pyng, Kou, Diana G, Chalupowicz, Heidi G, Feldser, Yolanda, Sanchez, Hong, Nie, James F, Callahan, Jeffrey K, Kerns, Patricia L, Podolin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(1)
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key regulator of oxidative stress and cellular repair and can be activated through inhibition of its cytoplasmic repressor, Kelch-like ECH-associated protein 1 (Keap1). Several small molecule di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6721d8982b84be2d15c27c3ee504816
https://pubmed.ncbi.nlm.nih.gov/28790194
https://pubmed.ncbi.nlm.nih.gov/28790194
Autor:
Jeremy D. A. Kitson, Kenneth L. Clark, Mark R. Edbrooke, Nigel J. Gooderham, Emma Koppe, William E. Wixted, Gaelle A. Douillard Guilloux, Linda C. Warnock, Joel D. Parry, Aliza Panjwani, Gemma Turner, Piotr J. Kamola, Paul A. Wilson, Klio Maratou, Stephen A. Hughes, Sofie Eriksson, Kitty Moores, Timothy W. Gant
Publikováno v:
Nucleic Acids Research
With many safety and technical limitations partly mitigated through chemical modifications, antisense oligonucleotides (ASOs) are gaining recognition as therapeutic entities. The increase in potency realized by 'third generation chemistries' may, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01232cad7ce261e9e3cf77f33d86c7c2
http://hdl.handle.net/10044/1/26355
http://hdl.handle.net/10044/1/26355
Autor:
William E. Wixted, Yolanda Sanchez, Wensheng Xie, Yan Liu, Roberto Solari, Hu Li, Nilesh Chitnis, James F. Callahan, Alan J. Diehl, Christina S. Pao, Maggie Truong, James A. Fornwald, Robert S. Ames, Marie Pariollaud
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119738 (2015)
PLoS ONE
PLoS ONE
Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD. PERK, one branch in the ER stress signaling pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8da42850efe895461fb0e79d7caf7b6
http://hdl.handle.net/10044/1/54073
http://hdl.handle.net/10044/1/54073
Autor:
Richard M. Keenan, Henry M. Sarau, Nambi Aiyar, David J. Behm, Schmidt Stanley J, Lisa T. Christmann, Steven D. Knight, William E. Wixted, Lance Ridgers, Peter T. Buckley, Timothy Francis Gallagher, James J. Foley, Graham J. Riley, John G Gleason, Jyoti Disa, Diane Naselsky, Dashyant Dhanak, Stephen A. Douglas, Jian Jin, Widdowson Katherine L, Dulcie B. Schmidt, David P. Brooks, Eliot H. Ohlstein
Publikováno v:
British Journal of Pharmacology. 145:620-635
1. SB-706375 potently inhibited [(125)I]hU-II binding to both mammalian recombinant and 'native' UT receptors (K(i) 4.7+/-1.5 to 20.7+/-3.6 nM at rodent, feline and primate recombinant UT receptors and K(i) 5.4+/-0.4 nM at the endogenous UT receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512cc94fd61162d159591dcd2189f2bc
https://doi.org/10.1038/sj.bjp.0706229
https://doi.org/10.1038/sj.bjp.0706229
A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma
Autor:
Mathias Chiano, Michael J. Wagner, Henry M. Sarau, Wayne H. Anderson, Mary E. Fling, Louise Hosking, Peter T. Buckley, Catherine S. Sprankle, Karen M. Kennedy-Wilson, Andrew Green, Dulcie B. Schmidt, William E. Wixted, Ashley A. Barnes, Lee-Ann Cameron, Diane M. Ignar, Sreekumar G. Pillai, Diane Joan Cousens, Jørgen Vestbo, James J. Foley, Malcolm N. Blumenthal
Publikováno v:
Pharmacogenetics. 14:627-633
Cysteinyl leukotrienes (CYSLTR) are potent biological mediators in the pathophysiology of asthma for which two receptors have been characterized, CYSLTR1 and CYSLTR2. The leukotriene modifying agents currently used to control bronchoconstriction and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6615a8b29396a21bc2fa5cc09e095a32
https://doi.org/10.1097/00008571-200409000-00007
https://doi.org/10.1097/00008571-200409000-00007
Autor:
William E. Wixted, Christopher L Herold, David J. Behm, Stephen A. Douglas, Peter T. Buckley, Henry M. Sarau, James J. Foley
Publikováno v:
British Journal of Pharmacology. 139:203-207
The functional activity of the peptidic neuromedin B receptor antagonist BIM-23127 was investigated at recombinant and native urotensin-II receptors (UT receptors). Human urotensin-II (hU-II) promoted intracellular calcium mobilization in HEK293 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56decc55b4aaec985d6b652f3228e2cb
https://doi.org/10.1038/sj.bjp.0705251
https://doi.org/10.1038/sj.bjp.0705251
Autor:
Jun U. Li, Emma J. Roberts, Jen P. Kou, Jayne C. Colebrook, Chris Kitson, William E. Wixted, Yolanda S. López-Boado, Steven M. Fox
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 24(1)
Chronic obstructive pulmonary disease (COPD) is an increasing health problem primarily associated with cigarette smoking, and one of the leading causes of morbidity and mortality worldwide. Despite recent advances in understanding the pathogenesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23cf853d7a16339aee39949ea920671
https://pubmed.ncbi.nlm.nih.gov/19706323
https://pubmed.ncbi.nlm.nih.gov/19706323