Výsledky vyhledávání - "William E. Smoyer"

Akademický článek

Glucocorticoid- and pioglitazone-induced proteinuria reduction in experimental NS both correlate with glomerular ECM modulation

Autor: Sagar Bhayana, Julie A. Dougherty, Yu Kamigaki, Shipra Agrawal, Saranga Wijeratne, James Fitch, Amanda P. Waller, Katelyn J. Wolfgang, Peter White, Bryce A. Kerlin, William E. Smoyer

Publikováno v: iScience, Vol 27, Iss 1, Pp 108631- (2024)

Summary: Idiopathic nephrotic syndrome (NS) is a common glomerular disease. Although glucocorticoids (GC) are the primary treatment, the PPARγ agonist pioglitazone (Pio) also reduces proteinuria in patients with NS and directly protects podocytes fr

Externí odkaz: https://doaj.org/article/04b04651bf1e4968a2534ecd12b2e81a

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Akademický článek

Clinical presentation and management of nephrotic syndrome in the first year of life: A report from the Pediatric Nephrology Research Consortium

Autor: Alexandru R. Constantinescu, Tej K. Mattoo, William E. Smoyer, Larry A. Greenbaum, Jianli Niu, Noel Howard, Melissa Muff-Luett, Elizabeth B. Benoit, Avram Traum, Ali A. Annaim, Scott E. Wenderfer, Emilee Plautz, Michelle N. Rheault, Robert L. Myette, Katherine E. Twombley, Yu Kamigaki, Belkis Wandique-Rapalo, Mohammad Kallash, Tetyana L. Vasylyeva

Publikováno v: Frontiers in Pediatrics, Vol 10 (2022)

Background and objectivesNephrotic syndrome (NS) in the first year of life is called congenital (CNS) if diagnosed between 0–3 months, or infantile (INS) if diagnosed between 3–12 months of age. The aim of this study was to determine if there wer

Externí odkaz: https://doaj.org/article/2c81f7d437a546a6b74c2da321434120

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Akademický článek

Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

Autor: Shannon L. Murphy, John D. Mahan, Jonathan P. Troost, Tarak Srivastava, Amy J. Kogon, Yi Cai, T. Keefe Davis, Hilda Fernandez, Alessia Fornoni, Rasheed A. Gbadegesin, Emily Herreshoff, Pietro A. Canetta, Patrick H. Nachman, Bryce B. Reeve, David T. Selewski, Christine B. Sethna, Chia-shi Wang, Sharon M. Bartosh, Debbie S. Gipson, Katherine R. Tuttle, Ali Gharavi, Wooin Ahn, Gerald B. Appel, Rupali S. Avasare, Revekka Babayev, Ibrahim Batal, Andrew S. Bomback, Eric Brown, Eric S. Campenot, Pietro Canetta, Brenda Chan, Vivette D. D’Agati, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Krzysztof Kiryluk, Fangming Lin, Francesca Lugani, Maddalena Marasa, Glen Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Jai Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, Simone Sanna-Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Larry A. Greenbaum, William E. Smoyer, Amira Al-Uzri, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Michael C. Braun, Aftab Chishti, Donna Claes, Carl Cramer, Keefe Davis, Elif Erkan, Daniel Feig, Michael Freundlich, Melisha Hanna, Guillermo Hidalgo, Amrish Jain, Myda Khalid, Mahmoud Kallash, MD, Jerome C. Lane, John Mahan, Nisha Mathews, Carla Nester, Cynthia Pan, Hiren Patel, Adelaide Revell, Rajasree Sreedharan, Julia Steinke, Scott E. Wenderfer, Craig S. Wong, Ronald Falk, William Cook, Vimal Derebail, Agnes Fogo, Adil Gasim, Todd Gehr, Raymond Harris, Jason Kidd, Louis-Philippe Laurin, Will Pendergraft, Vincent Pichette, Thomas Brian Powell, Matthew B. Renfrow, Virginie Royal, Lawrence B. Holzman, Sharon Adler, Charles Alpers, Raed Bou Matar, Elizabeth Brown, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Crystal Gadegbeku, Patrick Gipson, Leah Hasely, Sangeeta Hingorani, Michelle A. Hladunewich, Jonathan Hogan, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Kevin V. Lemley, Laura Malaga- Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O'Shaughnessy, John F. O’Toole, Rulan Parekh, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, John R. Sedor, Jeffrey Schelling, John C. Sperati, Agnes Swiatecka-Urban, Howard Trachtman, Joseph Weisstuch, Olga Zhdanova, Brenda Gillespie, Matthias Kretzler, Bruce M. Robinson, Laura Mariani, Matthew Wladkowski, Lisa M. Guay-Woodford

Publikováno v: Kidney International Reports, Vol 5, Iss 10, Pp 1679-1689 (2020)

Introduction: Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL with changing disease status. Methods: Cu

Externí odkaz: https://doaj.org/article/22aaf2057cd54d10aa49074d880c6040

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Akademický článek

Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Metabolomics

Autor: Jessica R. Gooding, Shipra Agrawal, Susan McRitchie, Zach Acuff, Michael L. Merchant, Jon B. Klein, William E. Smoyer, Susan J. Sumner, John Mahan, Hiren Patel, Richard F. Ransom, Cynthia Pan, Denis F. Geary, Myra L. Chang, Keisha L. Gibson, Franca M. Iorember, Patrick D. Brophy, Tarak Srivastava, Larry A. Greenbaum

Publikováno v: Kidney International Reports, Vol 5, Iss 1, Pp 81-93 (2020)

Introduction: Nephrotic syndrome (NS) is a kidney disease that affects both children and adults. Glucocorticoids have been the primary therapy for >60 years but are ineffective in approximately 20% of children and approximately 50% of adult patients.

Externí odkaz: https://doaj.org/article/1b5280e5d877451bafee09b406b2ee8f

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Akademický článek

Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Proteomics

Publikováno v: Kidney International Reports, Vol 5, Iss 1, Pp 66-80 (2020)

Introduction: Nephrotic syndrome (NS) is a characterized by massive proteinuria, edema, hypoalbuminemia, and dyslipidemia. Glucocorticoids (GCs), the primary therapy for >60 years, are ineffective in approximately 50% of adults and approximately 20%

Externí odkaz: https://doaj.org/article/4a6071bc69c54f03bf4f8c130ca5d000

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Akademický článek

Improving data quality in observational research studies: Report of the Cure Glomerulonephropathy (CureGN) network

Publikováno v: Contemporary Clinical Trials Communications, Vol 22, Iss , Pp 100749- (2021)

Background: High data quality is of crucial importance to the integrity of research projects. In the conduct of multi-center observational cohort studies with increasing types and quantities of data, maintaining data quality is challenging, with few

Externí odkaz: https://doaj.org/article/d1973b61d7b54609afc7c0310d857eeb

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Akademický článek

Nephrotic syndrome‐associated hypercoagulopathy is alleviated by both pioglitazone and glucocorticoid which target two different nuclear receptors

Autor: Amanda P. Waller, Shipra Agrawal, Katelyn J. Wolfgang, Jiro Kino, Melinda A. Chanley, William E. Smoyer, Bryce A. Kerlin, the Pediatric Nephrology Research Consortium (PNRC)

Publikováno v: Physiological Reports, Vol 8, Iss 15, Pp n/a-n/a (2020)

Abstract Background Thrombosis is a potentially life‐threatening nephrotic syndrome (NS) complication. We have previously demonstrated that hypercoagulopathy is proportional to NS severity in rat models and that pioglitazone (Pio) reduces proteinur

Externí odkaz: https://doaj.org/article/23bc302f0c7646d5ad136c2f79753e1d

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Akademický článek

Rituximab Use in the Management of Childhood Nephrotic Syndrome

Autor: Mahmoud Kallash, William E. Smoyer, John D. Mahan

Publikováno v: Frontiers in Pediatrics, Vol 7 (2019)

Childhood nephrotic syndrome is a challenging and often persistent renal disorder, and its incidence varies between different ethnicities and regions. Corticosteroids have been the main treatment for decades and are effective in most children with id

Externí odkaz: https://doaj.org/article/9ca744316f684b4391be5d1024012367

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