Zobrazeno 1 - 10
of 12
pro vyhledávání: '"William E. Orr"'
Publikováno v:
Neurochemical Research. 36:569-573
The present study examines the effects of Cd81-null mutation on the development of the retinal pigment epithelium (RPE), specifically cell size and number of cells with multiple nuclei. The outlines of RPE in retinal flat mounts were stained with rho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c791dc7e42469fa876aeec3e483da463
https://doi.org/10.1007/s11064-010-0268-2
https://doi.org/10.1007/s11064-010-0268-2
Autor:
Monica M. Jablonski, Lu Lu, Eldon E. Geisert, William E. Orr, Robert W. Williams, Justin P. Templeton, Natalie E. Freeman
Publikováno v:
Neurochemical Research. 36:594-603
Müller cells serve many functions including the regulation of extracellular glutamate levels. The product of two genes, Slc1a3 [aka solute carrier family 1 (glial high affinity glutamate transporter), member 3] and Glul (aka glutamine synthetase) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b2ba1890348f3635fdb09137d2795c
https://doi.org/10.1007/s11064-010-0277-1
https://doi.org/10.1007/s11064-010-0277-1
Autor:
Renukadevi Patil, Wei Li, Charles R. Yates, XiangDi Wang, Eldon E. Geisert, Fei Ma, William E. Orr, Shivaputra A. Patil, Duane D. Miller
Publikováno v:
Medicinal Chemistry Research. 20:131-137
Novel tetrahydroisoquinoline (THI) analogs were designed, synthesized, and their antiglioma activity was evaluated. The results showed that 6,8-dimethoxy-1-(2′-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (25) demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7537c732b6c2f6d1dbdee8392421da
https://doi.org/10.1007/s00044-010-9356-8
https://doi.org/10.1007/s00044-010-9356-8
Autor:
Suma Ramagiri, Fan Wang, Charles R. Yates, William E. Orr, XiangDi Wang, Eldon E. Geisert, Fei Ma, Duane D. Miller, Renukadevi Patil, Pengfei Song
Publikováno v:
Cancer Chemotherapy and Pharmacology. 61:1037-1044
Tetrahydroisoquinolines (THIs) have demonstrated anti-cancer activity in rodent models of glioma, a form of brain cancer refractory to therapeutic intervention. In this study, peripheral and cerebrospinal fluid (CSF) pharmacokinetics in rats were det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421be3b43ed48fbd2762f266266fc030
https://doi.org/10.1007/s00280-007-0563-z
https://doi.org/10.1007/s00280-007-0563-z
Autor:
Robert D. Yee, William E. Orr, Sean O'Connor, Ting-Kai Li, Kathleen Miller, Tanya Blekher, James D. Beard, Vijay A. Ramchandani
Publikováno v:
Alcoholism: Clinical and Experimental Research. 26:232-238
Background: The primary goal of this study was to evaluate how race and sex interact with the effects of a moderate dose of alcohol on different ocular control subsystems in African American (AA) and non-Hispanic white American (WA) college students.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6428e30d25bb1a1a1e5bad990795b687
https://doi.org/10.1111/j.1530-0277.2002.tb02529.x
https://doi.org/10.1111/j.1530-0277.2002.tb02529.x
Autor:
Shivaputra A. Patil, Suchareeta Mitra, XiangDi Wang, Renukadevi Patil, Clint W. Abner, Charles R. Yates, Duane D. Miller, William E. Orr, Natalie E. Freeman, Eldon E. Geisert
Publikováno v:
Anti-cancer drugs. 23(5)
To investigate the effectiveness of EDL-291, a 6,7-dimethoxy-1-[4-(4-methoxypyridin-3-yl)benzyl]-1,2,3,4-tetrahydroisoquinoline dihydrochloride compound, in inhibiting the survival of glioblastoma in vitro and in vivo. Dose-response curves were gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a5d33b8f41d7dab89535bb3b92a526
https://pubmed.ncbi.nlm.nih.gov/22391460
https://pubmed.ncbi.nlm.nih.gov/22391460
Autor:
Natalie E, Freeman, Justin P, Templeton, William E, Orr, Lu, Lu, Robert W, Williams, Eldon E, Geisert
Publikováno v:
Molecular Vision
Purpose The present study examines the structure and covariance of endogenous variation in gene expression across the recently expanded family of C57BL/6J (B) X DBA/2J (D) Recombinant Inbred (BXD RI) strains of mice. This work is accompanied by a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0117bcd9449b52c689912b18800b7682
https://pubmed.ncbi.nlm.nih.gov/21655357
https://pubmed.ncbi.nlm.nih.gov/21655357
Autor:
William E. Orr, Duane D. Miller, Oleg V. Kirichenko, Eldon E. Geisert, Renukadevi Patil, Gyong-Suk Kang, Michael L. Mohler, Xiang Di Wang
Publikováno v:
Anti-cancer drugs. 19(9)
The effects of 1-(biphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol (EDL-155) on the growth of glioma was tested in vitro and in vivo. Normal cultured rat astrocytes and C6 rat glioma were used as a differential screen to test the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784f133d3622c1bdbeed1c9927f1e49a
https://pubmed.ncbi.nlm.nih.gov/18766000
https://pubmed.ncbi.nlm.nih.gov/18766000
Publikováno v:
BMC Ophthalmology
BMC Ophthalmology, Vol 5, Iss 1, p 25 (2005)
BMC Ophthalmology, Vol 5, Iss 1, p 25 (2005)
Background Retinal pigment epithelium cells play an important role in the pathogenesis of age related macular degeneration. Their morphological, molecular and functional phenotype changes in response to various stresses. Functional profiling of genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5609ce99e33b66a47c0fc1b2c24e062a
https://pubmed.ncbi.nlm.nih.gov/16262907
https://pubmed.ncbi.nlm.nih.gov/16262907
Autor:
Vijay A. Ramchandani, William E. Orr, Paul Y. Kwo, James D. Beard, Holly R. Thomasson, Ting-Kai Li
Publikováno v:
Alcoholism: Clinical and Experimental Research. 24:415-416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4db49d877459e5b8cc80c813b70855d
https://doi.org/10.1111/j.1530-0277.2000.tb02002.x
https://doi.org/10.1111/j.1530-0277.2000.tb02002.x