Zobrazeno 1 - 10
of 29
pro vyhledávání: '"William E. O'Gorman"'
Autor:
Michael Fehlings, Suchit Jhunjhunwala, Marcin Kowanetz, William E. O’Gorman, Priti S. Hegde, Hermi Sumatoh, Boon Heng Lee, Alessandra Nardin, Etienne Becht, Susan Flynn, Marcus Ballinger, Evan W. Newell, Mahesh Yadav
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background There is strong evidence that immunotherapy-mediated tumor rejection can be driven by tumor-specific CD8+ T cells reinvigorated to recognize neoantigens derived from tumor somatic mutations. Thus, the frequencies or characteristic
Externí odkaz:
https://doaj.org/article/521c2f3238b047f6a7391405547e902b
Autor:
Shadi Toghi Eshghi, Amelia Au-Yeung, Chikara Takahashi, Christopher R. Bolen, Maclean N. Nyachienga, Sean P. Lear, Cherie Green, W. Rodney Mathews, William E. O'Gorman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Dimensionality reduction using the t-Distributed Stochastic Neighbor Embedding (t-SNE) algorithm has emerged as a popular tool for visualizing high-parameter single-cell data. While this approach has obvious potential for data visualization it remain
Externí odkaz:
https://doaj.org/article/8d2df7532958427ba25ff952ae0e2d72
Autor:
Marcin Kowanetz, Thomas Powles, Hartmut Koeppen, Jane Grogan, Patrick Caplazi, Ira Mellman, Wei Zou, Sanjeev Mariathasan, Priti S. Hegde, Mark McCleland, Jacqueline McBride, Zora Modrusan, Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, III, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Shadi Toghi Eshgi, W. Rodney Mathews, William E O'Gorman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background CD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.Methods Here,
Externí odkaz:
https://doaj.org/article/ccc1e210948b41af9f921790f0cfde0d
Autor:
Maha K. Rahim, Trine Line H. Okholm, Kyle B. Jones, Elizabeth E. McCarthy, Candace C. Liu, Jacqueline L. Yee, Stanley J. Tamaki, Diana M. Marquez, Iliana Tenvooren, Katherine Wai, Alexander Cheung, Brittany R. Davidson, Vrinda Johri, Bushra Samad, William E. O’Gorman, Matthew F. Krummel, Annemieke van Zante, Alexis J. Combes, Michael Angelo, Lawrence Fong, Alain P. Algazi, Patrick Ha, Matthew H. Spitzer
Publikováno v:
Cell. 186:1127-1143.e18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1adcb1f777b2b3be53c21bd5c520c93c
https://doi.org/10.1016/j.cell.2023.02.021
https://doi.org/10.1016/j.cell.2023.02.021
Autor:
William E. O'Gorman, J Ojeda-Garcia, Andrew Fuller, Jacqueline McBride, Gillian Hulme, John C. Mansfield, David McDonald, Christopher A. Lamb, John A. Kirby, J Doyle, Katie Cooke, Amelia Au-Yeung, R A Speight, Andrew Filby
Publikováno v:
Journal of Crohn's and Colitis. 15:S123-S125
Background Conventional cellular phenotyping of intestinal cell populations by multi-parameter fluorescence cytometry is reliant on collection of fresh tissue for immediate enzymatic or mechanical disaggregation, or cryopreservation of samples. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e060ca1eb81050722aea43e667ed9354
https://doi.org/10.1093/ecco-jcc/jjab076.131
https://doi.org/10.1093/ecco-jcc/jjab076.131
Autor:
Karl L, Banta, Xiaozheng, Xu, Avantika S, Chitre, Amelia, Au-Yeung, Chikara, Takahashi, William E, O'Gorman, Thomas D, Wu, Stephanie, Mittman, Rafael, Cubas, Laetitia, Comps-Agrar, Amit, Fulzele, Eric J, Bennett, Jane L, Grogan, Enfu, Hui, Eugene Y, Chiang, Ira, Mellman
Publikováno v:
Immunity. 55(3)
Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT blockade modulate anti-tumor CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d237098913f41245956df8c61565e97
https://pubmed.ncbi.nlm.nih.gov/35263569
https://pubmed.ncbi.nlm.nih.gov/35263569
Autor:
W. Rodney Mathews, Ying-Jiun Chen, Marcin Kowanetz, Jane L. Grogan, Chikara Takahashi, Mark McCleland, Ira Mellman, Thomas Powles, Jacqueline McBride, Mark D. Robida, Avantika S. Chitre, William E. O'Gorman, Shravan Madireddi, Hartmut Koeppen, Edward E. Kadel, Zora Modrusan, Patrick Caplazi, Thomas D. Wu, Shadi Toghi Eshgi, Alexis Scherl, Rhea Nersesian, Ehab Elgabry, Amelia Au-Yeung, Jeffrey Hung, Namrata Patil, Wei Zou, Priti Hegde, Patrícia de Almeida, Sanjeev Mariathasan, Romain Banchereau
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundCD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.MethodsHere, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973117f29bc29683e2495f0620864a71
https://jitc.bmj.com/content/9/4/e002231.full
https://jitc.bmj.com/content/9/4/e002231.full
Autor:
Namrata S. Patil, Barzin Y. Nabet, Sören Müller, Hartmut Koeppen, Wei Zou, Jennifer Giltnane, Amelia Au-Yeung, Shyam Srivats, Jason H. Cheng, Chikara Takahashi, Patricia E. de Almeida, Avantika S. Chitre, Jane L. Grogan, Linda Rangell, Sangeeta Jayakar, Maureen Peterson, Allison W. Hsia, William E. O’Gorman, Marcus Ballinger, Romain Banchereau, David S. Shames
Publikováno v:
Cancer Cell. 40:289-300.e4
Inhibitors of the programmed cell death-1 (PD-1/PD-L1) signaling axis are approved to treat non-small cell lung cancer (NSCLC) patients, based on their significant overall survival (OS) benefit. Using transcriptomic analysis of 891 NSCLC tumors from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1819ce15d429daff54cb2e2e0cccbb6e
https://doi.org/10.1016/j.ccell.2022.02.002
https://doi.org/10.1016/j.ccell.2022.02.002
Autor:
Karl L. Banta, Xiaozheng Xu, Avantika S. Chitre, Amelia Au-Yeung, Chikara Takahashi, William E. O’Gorman, Thomas D. Wu, Stephanie Mittman, Rafael Cubas, Laetitia Comps-Agrar, Amit Fulzele, Eric J. Bennett, Jane L. Grogan, Enfu Hui, Eugene Y. Chiang, Ira Mellman
Publikováno v:
Immunity. 55:512-526.e9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3942a7e957a961c22110f86bd394d059
https://doi.org/10.1016/j.immuni.2022.02.005
https://doi.org/10.1016/j.immuni.2022.02.005
Autor:
Mark M. Davis, William E. O'Gorman, Christopher R. Bolen, D.S. Kong, Debashis Ghosh, Elena W Y Hsieh, Imelda Balboni, Garry P. Nolan, Pratyaydipta Rudra
Publikováno v:
Journal of Autoimmunity. 81:74-89
Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease with heightened disease severity in children. The incomplete understanding of the precise cellular and molecular events that drive disease activity pose a significant hurdle to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d205d553828380d6bd9ee1817df6eba4
https://doi.org/10.1016/j.jaut.2017.03.010
https://doi.org/10.1016/j.jaut.2017.03.010