Zobrazeno 1 - 10
of 208
pro vyhledávání: '"William E. Louch"'
Autor:
Thea Parsberg Støle, Marianne Lunde, Katja Gehmlich, Geir Christensen, William E. Louch, Cathrine Rein Carlson
Publikováno v:
Cells, Vol 13, Iss 11, p 947 (2024)
The transmembrane proteoglycan syndecan-4 is known to be involved in the hypertrophic response to pressure overload. Although multiple downstream signaling pathways have been found to be involved in this response in a syndecan-4-dependent manner, the
Externí odkaz:
https://doaj.org/article/a80e016c709544b3aaf395d5c3d1981e
Autor:
Karoline B. Rypdal, A. Olav Melleby, Emma L. Robinson, Jia Li, Sheryl Palmero, Deborah E. Seifert, Daniel Martin, Catelyn Clark, Begoña López, Kristine Andreassen, Christen P. Dahl, Ivar Sjaastad, Theis Tønnessen, Mathis K. Stokke, William E. Louch, Arantxa González, Stephane Heymans, Geir Christensen, Suneel S. Apte, Ida G. Lunde
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The role of ADAMTSL3 in heart pathology and cardiac disease is investigated with Adamtsl3-deficient mice using CRISPR-Cas9 gene editing.
Externí odkaz:
https://doaj.org/article/8dc2cdb39a0043879864fac9c8cf91a5
Autor:
Erwin De Genst, Kylie S. Foo, Yao Xiao, Eduarde Rohner, Emma de Vries, Jesper Sohlmér, Nevin Witman, Alejandro Hidalgo, Terje R. S. Kolstad, William E. Louch, Susanne Pehrsson, Andrew Park, Yasuhiro Ikeda, Xidan Li, Lorenz M. Mayr, Kate Wickson, Karin Jennbacken, Kenny Hansson, Regina Fritsche-Danielson, James Hunt, Kenneth R. Chien
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here the authors use modified RNA and VHH libraries to generate intrabodies that target dysregulated interactions between two calcium handling proteins in failing cardiomyocytes. Heart specific expression of the intrabodies in a murine heart failure
Externí odkaz:
https://doaj.org/article/41820d2e39ea4787978141037e15dc1e
Autor:
Per Kristian Lunde, Ornella Manfra, Thea Parsberg Støle, Marianne Lunde, Marita Martinsen, Cathrine Rein Carlson, William E. Louch
Publikováno v:
Cells, Vol 12, Iss 19, p 2358 (2023)
Cell-penetrating peptides (CPPs) are short peptide sequences that have the ability to cross the cell membrane and deliver cargo. Although it is critical that CPPs accomplish this task with minimal off-target effects, such actions have in many cases n
Externí odkaz:
https://doaj.org/article/719956cc1ad244c2a4cf2c633a41ec65
Autor:
Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara, Kenneth R. Chien
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Abstract Background The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be clarified. Previous st
Externí odkaz:
https://doaj.org/article/01255acd28e041f6acfa35e58ea55910
Autor:
Niels Grote Beverborg, Daniela Später, Ralph Knöll, Alejandro Hidalgo, Steve T. Yeh, Zaher Elbeck, Herman H. W. Silljé, Tim R. Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér, Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F. Hoes, Cornelis J. Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E. Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R. Chien, Kenny M. Hansson, Adam E. Mullick, Rudolf A. de Boer, Peter van der Meer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ische
Externí odkaz:
https://doaj.org/article/fe3711b0c9be44609d25d2ed5e1f2344
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Complementary developments in microscopy and mathematical modeling have been critical to our understanding of cardiac excitation–contraction coupling. Historically, limitations imposed by the spatial or temporal resolution of imaging methods have b
Externí odkaz:
https://doaj.org/article/863450cded80490ca77dc5c57c6bbb62
Autor:
Junlan Zhou, Neha Singh, Chloe Monnier, William Marszalec, Li Gao, Jing Jin, Michael Frisk, William E. Louch, Suresh Verma, Prasanna Krishnamurthy, Elsa Nico, Maaz Mulla, Gary L. Aistrup, Raj Kishore, J. Andrew Wasserstrom
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and phosphatidylinositol-4,5-bisphosphate (PIP2) is responsible for localization of BIN1 to sarcolemma. The goal of this study was to determine if PIP2-mediated targeti
Externí odkaz:
https://doaj.org/article/6d65aa37066c4ce8a35e0b34b74789aa
Autor:
Andrew G. Edwards, Halvor Mørk, Mathis K. Stokke, David B. Lipsett, Ivar Sjaastad, Sylvain Richard, Ole M. Sejersted, William E. Louch
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Dysfunctional sarcoplasmic reticulum Ca2+ handling is commonly observed in heart failure, and thought to contribute to arrhythmogenesis through several mechanisms. Some time ago we developed a cardiomyocyte-specific inducible SERCA2 knockout mouse, w
Externí odkaz:
https://doaj.org/article/b7ca2ebc5ac344738eb358c23cf1d9c9
Autor:
Ingunn E. Setterberg, Christopher Le, Michael Frisk, Harmonie Perdreau-Dahl, Jia Li, William E. Louch
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/4654bd9294654b9096543d45a3f94b44