Zobrazeno 1 - 10
of 34
pro vyhledávání: '"William E. Jacobus"'
Autor:
William E. Jacobus, S M Krause
Publikováno v:
Journal of Biological Chemistry. 267:2480-2486
The kinetic influence of bound creatine kinase (CK) on the Ca(2+)-activated myosin ATPase was evaluated. ATPase rates were measured from 0.8 microM to 3.2 mM MgATP. Under control conditions, the apparent KmATP was 79.9 +/- 13.3 microM. In contrast, t
Publikováno v:
Journal of Biological Chemistry. 266:20296-20304
To further evaluate the bioenergetic role of phosphocreatine, we assessed several parameters in normal and depleted rat hearts. Rats were fed (8 weeks) a diet containing either 1% beta-guanidinoproprionic acid or 2% beta-guanidinobutyric acid (beta-G
Publikováno v:
Journal of Biological Chemistry. 255:755-763
Publikováno v:
Journal of Magnetic Resonance (1969). 29:319-330
31 P NMR at 72.9 MHz using a 25-mm-diameter phosphorus probe has been used to study correlations among cardiac metabolism, tissue pH, and contractile performance. In all studies, isovolumic left ventricular pressure (LVP) was measured in the paced he
Publikováno v:
Journal of Molecular and Cellular Cardiology. 14:13-20
31P was used to investigate correlations between intracellular pH (pHi) and myocardial contractility in the normal and ischemic isolated, perfused isovolumic rabbit heart. Intracellular pH was calculated from the chemical shift of Pi in hearts perfus
Autor:
Michael V. Miceli, Gary Gerstenblith, J. A. Hoerter, Edward G. Lakatta, Dale G. Renlund, William E. Jacobus
Publikováno v:
Circulation Research. 58:539-551
Isolated adult rat hearts perfused in an isovolumic mode were used to study the effects of sodium-potassium pump inhibition and sodium-calcium exchange alterations on the tissue content of adenosine triphosphate, phosphocreatine, inorganic phosphate,
Publikováno v:
Journal of Molecular and Cellular Cardiology. 14:1-12
This report summarizes the results of our recent research on the creatine kinase isozymes associated with the cardiac mitochondrial and sarcolemmal membranes and also describes some unique properties of the sarcolemmal protein kinase reaction. In hea
Publikováno v:
Circulation Research. 62:609-619
The pathophysiology of the ventricular fibrillation that complicates digitalis intoxication was investigated. In this and other calcium-overload states, oscillations of the intracellular free calcium concentration ([Ca2+]i) have been implicated as th
Publikováno v:
Journal of Molecular and Cellular Cardiology. 19:953-964
Impaired energy production has been proposed as one mechanism to explain the contractile abnormality in post-ischemic "stunned" myocardium. If energy production were impaired, administration of inotropic agents should result in a deterioration of cel
Publikováno v:
Annals of the New York Academy of Sciences. 414:73-89
Three important points must be emphasized in summary. First is the idea that a cellular microcompartment need not be limited by a semi-permeable membrane. We recognize microcompartments in multi-enzyme complexes where substrates are covalently transp