Zobrazeno 1 - 10
of 153
pro vyhledávání: '"William E. Hughes"'
Autor:
Jaimy Jose, Monira Hoque, Johanna Engel, Syed S. Beevi, Mohamed Wahba, Mariya Ilieva Georgieva, Kendelle J. Murphy, William E. Hughes, Blake J. Cochran, Albert Lu, Francesc Tebar, Andrew J. Hoy, Paul Timpson, Kerry-Anne Rye, Carlos Enrich, Carles Rentero, Thomas Grewal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Cholesterol is considered indispensable for cell motility, but how physiological cholesterol pools enable cells to move forward remains to be clarified. The majority of cells obtain cholesterol from the uptake of Low-Density lipoproteins (LD
Externí odkaz:
https://doaj.org/article/d41d8cbae8614657a10cbd861eb353d6
Autor:
Kristen D. Turner, Ana Kronemberger, Dam Bae, Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Luis G. O. de Sousa, Matthew P. Harris, Ethan J. Anderson, Sue C. Bodine, M. Bridget Zimmerman, Darren P. Casey, Vitor A. Lira
Publikováno v:
Nutrients, Vol 14, Iss 21, p 4479 (2022)
Nitric oxide (NO) stimulates mitochondrial biogenesis in skeletal muscle. However, NO metabolism is disrupted in individuals with type 2 diabetes mellitus (T2DM) potentially contributing to their decreased cardiorespiratory fitness (i.e., VO2max) and
Externí odkaz:
https://doaj.org/article/f0c4a9ef66794e1fb98cdb528fdffe87
Autor:
Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Darren P. Casey
Publikováno v:
Physiological Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Microvascular endothelial dysfunction precipitates cardiovascular disease mortality in patients with type 2 diabetes mellitus (T2DM). However, the relationship between glycemic management and microvascular endothelial function of these patie
Externí odkaz:
https://doaj.org/article/f0e6e48dd2f14c91be99827c73b09415
Publikováno v:
Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Objective The objective of this study was to measure flow‐mediated dilation (FMD) prior to and following transient increases in intraluminal pressure (IILP) in resistance arterioles isolated from subjects with and without coronary artery d
Externí odkaz:
https://doaj.org/article/6887ecfe791143dda3a1db67dee61ba6
Autor:
Anne Karine Lagendijk, Guillermo A. Gomez, Sungmin Baek, Daniel Hesselson, William E. Hughes, Scott Paterson, Daniel E. Conway, Heinz-Georg Belting, Markus Affolter, Kelly A. Smith, Martin A. Schwartz, Alpha S. Yap, Benjamin M. Hogan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Mechanical forces play a crucial role during morphogenesis, but how these are sensed and transduced in vivo is not fully understood. Here the authors apply a FRET tension sensor to live zebrafish and study changes in VE-cadherin tension at endothelia
Externí odkaz:
https://doaj.org/article/05f4c034d6774bbe95030ef2e8d3c537
Autor:
Christoph Jandl, Sue M. Liu, Pablo F. Cañete, Joanna Warren, William E. Hughes, Alexis Vogelzang, Kylie Webster, Maria E. Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.
Externí odkaz:
https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa0
Autor:
Wesley K. Lefferts, Jacqueline A. Augustine, Nicole L. Spartano, William E. Hughes, Matthew C. Babcock, Brigid K. Heenan, Kevin S. Heffernan
Publikováno v:
Nutrients, Vol 12, Iss 4, p 1054 (2020)
ANCHORS A-WHEY was a 12-week randomized controlled trial (RCT) designed to examine the effect of whey protein on large artery stiffness, cerebrovascular responses to cognitive activity and cognitive function in older adults. Methods: 99 older adults
Externí odkaz:
https://doaj.org/article/07e48cd92922480b91c3d9fcbb8e5345
Autor:
Kevin S. Heffernan, Nicole L. Spartano, Jacqueline A. Augustine, Wesley K. Lefferts, William E. Hughes, Gary F. Mitchell, Randall S. Jorgensen, Brooks B. Gump
Publikováno v:
Artery Research, Vol 8, Iss 4 (2014)
Externí odkaz:
https://doaj.org/article/3c4f159b316c44e083636b5eb236494d
Autor:
William E. Hughes, Nicole L. Spartano, Wesley K. Lefferts, Jaqueline A. Augustine, Kevin S. Heffernan
Publikováno v:
Artery Research, Vol 8, Iss 4 (2014)
Background: Sex differences in arterial stiffness and wave reflections may lead to disproportionate increases in afterload and myocardial work in women. We examined sex differences in arterial stiffness, pressure from wave reflections, measures of le
Externí odkaz:
https://doaj.org/article/84e4026ad8e947738340601a045522af
Publikováno v:
Nutr Metab Cardiovasc Dis
BACKGROUND & AIMS: Peripheral artery disease (PAD) is characterized by elevated blood pressure (BP), low nitric oxide availability (NO), and exaggerated pressor responses to sympatho-excitatory stressors. Inorganic nitrate reduces peripheral BP in he