Zobrazeno 1 - 10
of 19
pro vyhledávání: '"William E. Hobbs"'
Autor:
David R. Light, Sharada A. Sarnaik, Moira M. Lancelot, Nancy Moore, Dipti Gupta, Patrick C. Hines, William E. Hobbs, Jennell White, Sriram Krishnamoorthy
Publikováno v:
British Journal of Haematology. 174:970-982
Summary Very Late Antigen-4 (VLA-4, α4β1-integrin, ITGA4) orchestrates cell-cell and cell-endothelium adhesion. Given the proposed role of VLA-4 in sickle cell disease (SCD) pathophysiology, we evaluated the ability of the VLA-4 blocking antibody n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c18a3818ea8ce196fff64f784758774
https://doi.org/10.1111/bjh.14158
https://doi.org/10.1111/bjh.14158
Autor:
Benjamin Vieira, Julia E. Brittain, Sarah Sturtevant, Sriram Krishnamoorthy, Dipti Gupta, Timothy Thullen, Levi Makala, Huo Li, Biaoru Li, David R. Light, Betty S. Pace, Ivan Stone, Nancy Moore, William E. Hobbs
Publikováno v:
JCI insight. 2(20)
Sickle cell disease (SCD) results from a point mutation in the β-globin gene forming hemoglobin S (HbS), which polymerizes in deoxygenated erythrocytes, triggering recurrent painful vaso-occlusive crises and chronic hemolytic anemia. Reactivation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb5635a1ada9604e54d51e3bd850136
https://pubmed.ncbi.nlm.nih.gov/29046485
https://pubmed.ncbi.nlm.nih.gov/29046485
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1230-1237
Objective— Cocaine use is associated with arterial thrombosis, including myocardial infarction and stroke. Cocaine use results in increased plasma von Willebrand factor (VWF), accelerated atherosclerosis, and platelet-rich arterial thrombi, suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a0ea2a63ac13ed16313d1fd48ab0c0
https://doi.org/10.1161/atvbaha.113.301436
https://doi.org/10.1161/atvbaha.113.301436
Publikováno v:
Journal of Virology. 76:2180-2191
The herpes simplex virus type 1 (HSV-1) mutantd109 does not express any of the immediate-early (IE) proteins and persists in cells for a prolonged length of time. As has been shown by Nicholl et al. (J. Gen. Virol. 81:2215-2218, 2000) and Mossman et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721177c73caa7365d7ae6d1344f57a74
https://doi.org/10.1128/jvi.76.5.2180-2191.2002
https://doi.org/10.1128/jvi.76.5.2180-2191.2002
Autor:
Gersham Dent, William E. Hobbs, Nicolas Currier, Jacobus Burggraaf, Jaladhar Neelavalli, Paul Swerdlow, Brijesh Kumar Yadav, Ajay Verma, W. Birkhoff, Muhammad Shahid, Jaspert de Vries
Publikováno v:
Blood. 128:4871-4871
Background: Vascular complications such as stroke and pulmonary hypertension are central features of sickle cell disease (SCD) pathophysiology and are associated with early mortality among patients with SCD. Better understanding of the abnormal blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d6e54e01f7c99a5e9649aaeb9f4fdc3
https://doi.org/10.1182/blood.v128.22.4871.4871
https://doi.org/10.1182/blood.v128.22.4871.4871
Autor:
Robert T. Peters, William E. Hobbs, Sarah Sturtevant, Benjamin Vieira, Dipti Gupta, Yukio Nakamura, Betty S. Pace, David R. Light, Christine Loh, Sriram Krishnamoorthy, Brian Lucas
Publikováno v:
Blood. 128:4840-4840
Sickle Cell Disease (SCD) is caused by a point mutation in the beta- chain of hemoglobin, triggering a complex pathophysiology resulting in recurrent, painful vaso-occlusive events (VOCs) and chronic hemolytic anemia. Induction of fetal hemoglobin (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9856e9d2a6e8f6f3d9a6e94b06881134
https://doi.org/10.1182/blood.v128.22.4840.4840
https://doi.org/10.1182/blood.v128.22.4840.4840
Autor:
William E. Hobbs, Neal A. DeLuca
Publikováno v:
Journal of Virology. 73:8245-8255
Herpes simplex virus type 1 is capable of inhibiting host cell DNA synthesis following lytic infection. However, the mechanism and nature of potential effects on cell cycle progression have not been described. In this report, we characterize the dysr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38aeeb1d6821c3e06c94be2429d6a84
https://doi.org/10.1128/jvi.73.10.8245-8255.1999
https://doi.org/10.1128/jvi.73.10.8245-8255.1999
Publikováno v:
Blood. 126:2057-2057
Central venous access devices (CVADs), such as tunneled central venous catheters (tCVADs) and peripherally inserted central catheters (PICCs), help provide essential care for some patients with sickle cell disease (SCD). CVADs facilitate administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03cc0654351c69c654705d96b7e7ed16
https://doi.org/10.1182/blood.v126.23.2057.2057
https://doi.org/10.1182/blood.v126.23.2057.2057
Autor:
Betty S. Pace, David R. Light, Sriram Krishnamoorthy, William E. Hobbs, Dipti Gupta, Sarah Sturtevant, Biaoru Li, Levi C Makala
Publikováno v:
Blood. 126:410-410
Sickle cell disease (SCD) is caused by a point mutation in the β-chain of hemoglobin, which triggers a complex pathophysiology resulting in recurrent, painful vaso-occlusive crises (VOC) and chronic hemolytic anemia. Fetal hemoglobin (HbF) is the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c93a810960d8ea85df1571026355c5d
https://doi.org/10.1182/blood.v126.23.410.410
https://doi.org/10.1182/blood.v126.23.410.410
Publikováno v:
Blood. 126:3278-3278
Beta(β)-thalassemia is a rare disease, with limited data available on the typical clinical course and outcomes of patients in the US. There are currently no nationwide surveillance efforts to monitor the prevalence or changes in outcomes among those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e537870f5c39b9230245fd32584197
https://doi.org/10.1182/blood.v126.23.3278.3278
https://doi.org/10.1182/blood.v126.23.3278.3278