Zobrazeno 1 - 10 of 27 pro vyhledávání: '"William E. Dowdle"'
1
Akademický článek
Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice
Autor: Xiaomeng Hu, Karl Manner, Rowena DeJesus, Kathy White, Corie Gattis, Priscilla Ngo, Christopher Bandoro, Eleonore Tham, Elaine Y. Chu, Chi Young, Frank Wells, Ronald Basco, Annabelle Friera, Divy Kangeyan, Pascal Beauchesne, William E. Dowdle, Tobias Deuse, Terry J. Fry, Aaron E. Foster, Sonja Schrepfer
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Manufacturing autologous chimeric antigen receptor (CAR) T cell therapeutics is complex, and many patients experience treatment delays or cannot be treated at all. Although current allogeneic CAR products have the potential to overcome manuf
Externí odkaz: https://doaj.org/article/11a7498d8b624c7f9293ade72a94e6d3
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2
Akademický článek
Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9
Autor: Jonathan M. Goodwin, William E. Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Marek Kobylarz, Alicia Lindeman, Ramnik J. Xavier, Gregory McAllister, Beat Nyfeler, Gregory Hoffman, Leon O. Murphy
Publikováno v: Cell Reports, Vol 20, Iss 10, Pp 2341-2356 (2017)
Iron is vital for many homeostatic processes, and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of sele
Externí odkaz: https://doaj.org/article/24a5ed36c1ec4393b84541c3dfccc45e
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5
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
Autor: Xiaomeng Hu, Corie Gattis, Ari G. Olroyd, Annabelle M. Friera, Kathy White, Chi Young, Ron Basco, Meghan Lamba, Frank Wells, Ramya Ankala, William E. Dowdle, August Lin, Kyla Egenberger, J. Michael Rukstalis, Jeffrey R. Millman, Andrew J. Connolly, Tobias Deuse, Sonja Schrepfer
Publikováno v: Science Translational Medicine. 15
Transplantation of allogeneic pancreatic donor islets has successfully been performed in selected patients with difficult-to-control insulin-dependent diabetes and impaired awareness of hypoglycemia (IAH). However, the required systemic immunosuppres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87ef67bc3b7c312fb3bf0929fddd52ca
https://doi.org/10.1126/scitranslmed.adg5794
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7
Abstract 4091: Engineered hypoimmune CAR T cells provide lasting tumor control in immunocompetent allogeneic humanized mice even with re-challenge
Autor: Xiaomeng Hu, Pascal Beauchesne, Karl Manner, Corie Gattis, Priscilla Ngo, Rowena De Jesus, Ramya Ankala, Chi Young, Frank Wells, Lindong Weng, Kathy White, William E. Dowdle, Aaron Foster, Terry J. Fry, Sonja Schrepfer
Publikováno v: Cancer Research. 83:4091-4091
Off-the-shelf CAR T cells potentially offer advantages over autologous strategies such as ease of manufacturing, quality control, off-the-shelf availability, and lack of T cell dysfunction, as well as the ability to generate a more consistent CAR T p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6779b9589985b935efe70e4f883f41b3
https://doi.org/10.1158/1538-7445.am2023-4091
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9
Abstract 5598: Engineered hypoimmune allogeneic CAR T cells as potential off-the-shelf CAR T cell immunotherapies
Autor: Xiaomeng Hu, Kathy White, Corie Gattis, Ryan Clarke, Sam Landry, Ron Basco, Eleonore Tham, Emily Luo, Andrew Tucker, Christopher Bandoro, Elaine Chu, Chi Young, Karl Manner, Priscilla Nho, Ben Lam, Pascal Beauchesne, Aaron Foster, William E. Dowdle, Edward J. Rebar, Terry J. Fry, Sonja Schrepfer
Publikováno v: Cancer Research. 82:5598-5598
Off-the-shelf CAR T cells may offer advantages over autologous strategies, including ease of manufacturing, improved quality control with avoidance of malignant contamination and T cell dysfunction, and the ability to generate a final product from he
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3da74a1da1f85fe790561b43db5502a0
https://doi.org/10.1158/1538-7445.am2022-5598
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10
Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity
Autor: Edward J. Rebar, Aaron E. Foster, Eleonore Tham, Elaine Chu, Chi Young, X. Hu, William E. Dowdle, Sam Landry, Mo Dao, Andrew Tucker, Terry J. Fry, Kathy White, Corie Gattis, Ron Basco, Emily Luo, Sonja Schrepfer, Ryan Clarke, Christopher Bandoro
Publikováno v: Blood. 138:1690-1690
Off-the-shelf CAR T cells may offer advantages over autologous strategies, including ease of manufacturing, improved quality control with avoidance of malignant contamination and T cell dysfunction as well as the ability to generate a final product f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61f5f38d7351bad697d2658f29b969dc
https://doi.org/10.1182/blood-2021-150021
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