Zobrazeno 1 - 10
of 136
pro vyhledávání: '"William E. Delaney"'
Autor:
Christopher Y. Chen, Benjamin Y. Winer, Deborah Chavez, Bernadette Guerra, Kathleen M. Brasky, Stacey Eng, Eduardo Salas, Danny Tam, Joe H. Simmons, Christian R. Abee, William E. Delaney, Alexander Ploss, Robert E. Lanford, Christian Voitenleitner
Publikováno v:
Hepatology Communications, Vol 4, Iss 3, Pp 371-386 (2020)
Development of curative therapies for chronic hepatitis B virus (HBV) infection will likely require new animal models. Here, we evaluate HBV infection in squirrel monkeys based on the high‐sequence homology of the HBV receptor, Na+/taurocholate co
Externí odkaz:
https://doaj.org/article/911c91724d604a958917fa3c7de7fa65
Autor:
Sarah A. Gilmore, Danny Tam, Tara L. Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y. Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M. Brendza, Todd C. Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H. Tay, William E. Delaney, Gregory T. Notte, Uli Schmitz, Becket Feierbach
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis B virus (HBV) infection, we performed a focused screen of epigenet
Externí odkaz:
https://doaj.org/article/4355fdfb180e49429f2014ad92f0c880
Autor:
Dara Burdette, Anastasia Hyrina, Zhijuan Song, Rudolf K. Beran, Tara Cheung, Sarah Gilmore, Tetsuya Kobayashi, Li Li, Yang Liu, Anita Niedziela-Majka, Jonathan Medley, Upasana Mehra, Philip Morganelli, Nikolai Novikov, Congrong Niu, Danny Tam, Jennifer Tang, Jianhong Wang, Qin Yue, Simon P. Fletcher, Meghan M. Holdorf, William E. Delaney, Becket Feierbach, Scott Lazerwith
Publikováno v:
Antimicrobial agents and chemotherapy.
The standard of care for the treatment of chronic hepatitis B (CHB) is typically lifelong treatment with nucleos(t)ide analogs (NAs), which suppress viral replication and provide long-term clinical benefits. However, infectious virus can still be det
Autor:
Ricardo Ramirez, Li Li, William E. Delaney, Stephan Menne, Sarina Ma, Changsuek Yon, Don Kang, Jason Chamberlain, Christian Voitenleitner, William Rowe, Ruth Chu, Dhivya Ramakrishnan, Magdeleine Hung, Manasa Suresh, Divya Pattabiraman, Stephane Daffis, Paul J. Cote, Rex Santos, Bei Li, Simon P. Fletcher, Scott Balsitis, Sandra Spurlock, Mish Michael R, Jim Zheng, Richard L. Mackman
Publikováno v:
Hepatology (Baltimore, Md.)
Background and aims GS-9688 (selgantolimod) is an oral selective small molecule agonist of toll-like receptor 8 in clinical development for the treatment of chronic hepatitis B. In this study, we evaluated the antiviral efficacy of GS-9688 in woodchu
Autor:
Benjamin Y. Winer, Kathleen M. Brasky, Robert E. Lanford, Christian R. Abee, William E. Delaney, Alexander Ploss, Deborah Chavez, Joe H. Simmons, Danny Tam, Christopher Y. Chen, Christian Voitenleitner, Eduardo Salas, Bernadette Guerra, Stacey Eng
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 4, Iss 3, Pp 371-386 (2020)
Hepatology Communications, Vol 4, Iss 3, Pp 371-386 (2020)
Development of curative therapies for chronic hepatitis B virus (HBV) infection will likely require new animal models. Here, we evaluate HBV infection in squirrel monkeys based on the high-sequence homology of the HBV receptor, Na+/taurocholate co-tr
Autor:
Cassandra L. Gorsuch, Paige Nemec, Mei Yu, Simin Xu, Dong Han, Jeff Smith, Janel Lape, Nicholas van Buuren, Ricardo Ramirez, Robert C. Muench, Meghan M. Holdorf, Becket Feierbach, Greg Falls, Jason Holt, Wendy Shoop, Emma Sevigny, Forrest Karriker, Robert V. Brown, Amod Joshi, Tyler Goodwin, Ying K. Tam, Paulo J.C. Lin, Sean C. Semple, Neil Leatherbury, William E. Delaney IV, Derek Jantz, Amy Rhoden Smith
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 30(9)
Persistence of chronic hepatitis B (CHB) is attributed to maintenance of the intrahepatic pool of the viral covalently closed circular DNA (cccDNA), which serves as the transcriptional template for all viral gene products required for replication. Cu
Autor:
Joy Chiu, Becket Feierbach, Mei Yu, Lindsay Gamelin, Ricardo Ramirez, Dong Han, Neeru Bhardwaj, Lindsey May, Nicholas van Buuren, Robert C. Muench, Hongmei Mo, Li Li, William E. Delaney, Cameron Soulette, Regina Choy, Guofeng Cheng
Publikováno v:
J Virol
Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, creating potentially oncogenic lesions that can lead to hepatocellular carcinoma (HCC). However, our current understanding of integrated HBV DNA architecture, burden,
Autor:
Becket Feierbach, Renae Walsh, Sally Soppe, Dara Burdette, Xupeng Hong, Jianming Hu, Megan Mendenhall, Liza Cabuang, William E. Delaney, Peter Revill, Laurie Luckenbaugh
Publikováno v:
J Virol
Current therapies rarely cure chronic hepatitis B virus (HBV) infection due to the persistence of the viral episome, the covalently closed circular DNA (cccDNA), in hepatocytes. The hepatitis B virus core-related antigen (HBcrAg), a mixture of the vi
Autor:
William E. Delaney, Dara Burdette, Lazerwith Scott E, Henry Chan, Jenny C. Yang, Becket Feierbach
Current approved therapies for Hepatitis B Virus (HBV) effectively control viral replication but are rarely curative. Patients on suppressive therapy still harbor cccDNA and cessation of therapy leads to rapid viral rebound 1-3. Even after long-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f6f990dc144add01352db0ffd9acef1
https://doi.org/10.21203/rs.3.rs-100058/v1
https://doi.org/10.21203/rs.3.rs-100058/v1
Autor:
Dara L Burdette, Scott Lazerwith, Jenny Yang, Henry L. Y. Chan, William E. Delaney IV, Simon P. Fletcher, Tomas Cihlar, Becket Feierbach
Publikováno v:
PLOS ONE. 17:e0262516
Nucleos(t)ide analogs are standard-of-care for the treatment of chronic hepatitis B and can effectively reduce hepatitis B virus (HBV) replication but rarely leads to cure. Nucleos(t)ide analogs do not directly eliminate the viral episome, therefore