Zobrazeno 1 - 10
of 66
pro vyhledávání: '"William E. Bechtold"'
Autor:
Darlene A. Hastings-Smith, Jonathan B. Ward, Judah I. Rosenblatt, Sherif Z. Abdel-Rahman, Marinel M. Ammenheuser, William E. Bechtold
Publikováno v:
Environmental Health Perspectives
1,3-Butadiene (BD), which is used to make styrene-butadiene rubber, is a potent carcinogen in mice and a probable carcinogen, associated with leukemia, in humans. We have previously used HPRT mutation as a biomarker to evaluate exposures to BD in a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ebf6dbe15dac702fd33fb619a89564
https://doi.org/10.1289/ehp.011091249
https://doi.org/10.1289/ehp.011091249
Publikováno v:
Toxicology. 160:81-86
The carcinogenicity of 1,3-butadiene (BD) varies greatly in the rodent species in which 2-year bioassay studies were completed. This raises the question of whether the risk of BD exposure in humans is more like that of the sensitive species, the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faa42e89f5d86209b29a68b6bc5d1a6
https://doi.org/10.1016/s0300-483x(00)00438-8
https://doi.org/10.1016/s0300-483x(00)00438-8
Autor:
Li Guilan, Silvia Fustinoni, Mustafa Dosemeci, Nathaniel Rothman, Songnian Yin, Suramya Waidyanatha, Richard B. Hayes, Stephen M. Rappaport, Martyn T. Smith, William E. Bechtold
Publikováno v:
Carcinogenesis. 22:279-286
Urinary benzene (UB) was investigated as a biomarker of exposure among benzene-exposed workers and unexposed subjects in Shanghai, China. Measurements were performed via headspace solid phase microextraction of 0.5 ml of urine specimens followed by g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fbb641b6a0d3ac0e3b87eb4872ab69
https://doi.org/10.1093/carcin/22.2.279
https://doi.org/10.1093/carcin/22.2.279
Autor:
Rogene F. Henderson, Alan R. Dahl, William C. Griffith, Janice R. Thornton-Manning, William E. Bechtold
Publikováno v:
Toxicology. 123:125-134
1,3-Butadiene (BD), a compound used extensively in the rubber industry, is a potent carcinogen in mice and a weak carcinogen in rats in chronic carcinogenicity bioassays. While many chemicals are known to alter their own metabolism after repeated exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c389ebf8cd289274e2db9cfd247bbc
https://doi.org/10.1016/s0300-483x(97)00112-1
https://doi.org/10.1016/s0300-483x(97)00112-1
Publikováno v:
Toxicology. 113:17-22
Species differences in the metabolism of 1,3-butadiene (BD) have been studied in an effort to explain the major differences observed in the responses of mice, the sensitive species, and rats, the resistant species, to the toxicity of inhaled BD. BD i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9ad9109ceafde9454f383a166ffaaf
https://doi.org/10.1016/0300-483x(96)03422-1
https://doi.org/10.1016/0300-483x(96)03422-1
Autor:
Y. Z. Wang, Liqiang Xi, Songnian Yin, William J. Blot, Nina Titenko-Holland, Martyn T. Smith, Richard B. Hayes, Luoping Zhang, Mustafa Dosemeci, William E. Bechtold, Gerald E. Marti, Nathaniel Rothman, Wei Lu, Gui-Lin Li, Martha S. Linet
Publikováno v:
American Journal of Industrial Medicine. 29:236-246
Benzene is a well-established hematotoxin. However, reports of its effects on specific blood cells have been somewhat inconsistent and the relative toxicity of benzene metabolites on peripheral blood cells in humans has not been evaluated. We compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b241696aacdb77babcdd705d76df08a8
https://doi.org/10.1002/(sici)1097-0274(199603)29:3<236::aid-ajim3>3.0.co
https://doi.org/10.1002/(sici)1097-0274(199603)29:3<236::aid-ajim3>3.0.co
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 335:267-273
The magnitude of health risks to workers associated with current and past exposures to butadiene has been the subject of considerable recent debate. Butadiene is metabolized in-vivo and in-vitro to the genotoxic intermediates 3,4-epoxybutene and diep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869b5072eda930c07684f8b14dafe16c
https://doi.org/10.1016/0165-1161(95)00030-5
https://doi.org/10.1016/0165-1161(95)00030-5
Publikováno v:
Chemical Research in Toxicology. 8:182-187
A new method was developed to quantify the levels of 1,3-butadiene (BD), butadiene monoxide (BDO), and butadiene diepoxide (BDO2) in blood. The method was based on vacuum distillation of tissues followed by analysis of the distillates using multidime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a36fe3e7b6631f5b9f0418d8b66493
https://doi.org/10.1021/tx00044a002
https://doi.org/10.1021/tx00044a002
Autor:
M. S. Legator, William E. Bechtold, Jonathan B. Ward, Elbert B. Whorton, Marinel M. Ammenheuser
Publikováno v:
Environmental Health Perspectives
1,3-Butadiene is a major industrial chemical that has been shown to be a carcinogen at multiple sites in mice and rats at concentrations as low as 6.25 ppm. Occupational exposures have been reduced in response to these findings, but it may not be pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0904776510f6e3390f189593781c1970
https://doi.org/10.1289/ehp.94102s979
https://doi.org/10.1289/ehp.94102s979
Autor:
Stanley A. Kline, William E. Bechtold, Gisela Witz, Bernard D. Goldstein, Andi Bartczak, Ryun Yu, Clifford P. Weisel
Publikováno v:
Journal of Toxicology and Environmental Health. 42:245-258
Muconic acid (MA) is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in humans exposed to levels as low as 1 ppm. We have modified a high-pressure liquid chromatography (HPLC) based assay for urinary MA (Ducos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b313f0bb1cf64717d18bde9c3fffab
https://doi.org/10.1080/15287399409531877
https://doi.org/10.1080/15287399409531877