Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William E. Barclay"'
Autor:
Jeremy J. Ratiu, William E. Barclay, Elliot Lin, Qun Wang, Sebastian Wellford, Naren Mehta, Melissa J. Harnois, Devon DiPalma, Sumedha Roy, Alejandra V. Contreras, Mari L. Shinohara, David Wiest, Yuan Zhuang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
T cell development involves extensive proliferation of developing thymocytes. Here, the authors demonstrate that the transcription factor Zfp335 regulates the survival post-β-selection thymocytes via the cGAS/STING pathway.
Externí odkaz:
https://doaj.org/article/1986148c7cbb4df0b7b4c12b62079982
Autor:
Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, Niccolò Terrando
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Neuroinflammation is a growing hallmark of perioperative neurocognitive disorders (PNDs), including delirium and longer-lasting cognitive deficits. We have developed a clinically relevant orthopedic mouse model to study the impact of a common surgica
Externí odkaz:
https://doaj.org/article/3f90cc2b6e234d0d8421d000968a995f
Autor:
William E. Barclay, Nupur Aggarwal, M. Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Edward A. Miao, Mari L. Shinohara
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory
Externí odkaz:
https://doaj.org/article/9f2d7b3e62ca454686293fc58c6fcbd1
Autor:
Yee Ming Khaw, Nupur Aggarwal, William E. Barclay, Eunjoo Kang, Makoto Inoue, Mari L. Shinohara
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS) is identified upon immune reconstitution in immunocompromised patients, who have previously contracted an infection of Cryptococcus neoformans (Cn). C-IRIS can be lethal but
Externí odkaz:
https://doaj.org/article/f6723395f9be48588f3f9fb73f038aac
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS
Externí odkaz:
https://doaj.org/article/562597864f864ccb8d4e580e0d1c1de9
Autor:
Makoto Inoue, Kengo Nozaki, Edward A. Miao, Mari L. Shinohara, Nupur Aggarwal, William E. Barclay, M. Elizabeth Deerhake, Toshiaki Nonaka, Nathan A. Luzum
Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740af11a1ddb5d2585167107a340fbb2
https://doi.org/10.1101/2021.10.03.462457
https://doi.org/10.1101/2021.10.03.462457
Autor:
Niccolò Terrando, Mari L. Shinohara, Ramona M. Rodriguiz, William C. Wetsel, Ravikanth Velagapudi, William E. Barclay, Zhiquan Zhang, Qing Ma
Neuroinflammation is a growing hallmark of perioperative neurocognitive disorders (PNDs), including delirium and longer-lasting cognitive deficits. We have developed a clinically-relevant orthopedic mouse model to study the impact of a common surgica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66dae2b78aaa99aa2b2299a1072c8e9f
https://doi.org/10.1101/2020.05.12.090654
https://doi.org/10.1101/2020.05.12.090654
Autor:
Mari L. Shinohara, William E. Barclay, Keiko Danzaki, Emre D. Cardakli, Nupur Aggarwal, Makoto Inoue, M. Elizabeth Deerhake, Toshiaki Nonaka, Ru-Rong Ji
Pathologic roles for innate immunity in neurologic disorders are well-described, but protective aspects of the immune response are less understood. Dectin-1, a C-type lectin receptor (CLR), is largely known to induce inflammation. However, we found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87082ddc0db77d8c163f2181a8960e7
Autor:
William E. Barclay, Mari L. Shinohara
Publikováno v:
Brain Pathology. 27:213-219
The aptly named inflammasomes are powerful signaling complexes that sense inflammatory signals under a myriad of conditions, including those from infections and endogenous sources. The inflammasomes promote inflammation by maturation and release of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce746ccf58590bf0e30ecee22de6f46
https://doi.org/10.1111/bpa.12477
https://doi.org/10.1111/bpa.12477
Autor:
Maria Ciofani, William E. Barclay, R. Lee Reinhardt, Tiffany Carr, Jianxuan Wu, Jingxiao Jin, Katherine Bao
Publikováno v:
The Journal of Immunology. 197:4371-4381
The AP-1 factor basic leucine zipper transcription factor, ATF-like (BATF) is important for CD4+ Th17, Th9, and follicular Th cell development. However, its precise role in Th2 differentiation and function remains unclear, and the requirement for BAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b7064555bfb2843ad0edcbf4bc00a4
https://doi.org/10.4049/jimmunol.1601371
https://doi.org/10.4049/jimmunol.1601371