Zobrazeno 1 - 10
of 50
pro vyhledávání: '"William E. B. Johnson"'
Publikováno v:
Biology, Vol 10, Iss 3, p 230 (2021)
Animal models have been used in preclinical research to examine potential new treatments for spinal cord injury (SCI), including mesenchymal stem cell (MSC) transplantation. MSC transplants have been studied in early human trials. Whether the animal
Externí odkaz:
https://doaj.org/article/733b5469401440c5a05d9a6bb0a1c7fd
Autor:
Ibtesam R. T. Al Delfi, Chelsea R. Wood, Louis D. V. Johnson, Martyn D. Snow, John F. Innes, Peter Myint, William E. B. Johnson
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1301 (2020)
The majority of research into the effects of mesenchymal stem cell (MSC) transplants on spinal cord injury (SCI) is performed in rodent models, which may help inform on mechanisms of action, but does not represent the scale and wound heterogeneity se
Externí odkaz:
https://doaj.org/article/99df03a1b31e476db2c916a96c5ae91e
Autor:
Ai Takahashi, Hideaki Nakajima, Kenzo Uchida, Naoto Takeura, Kazuya Honjoh, Shuji Watanabe, Makoto Kitade, Yasuo Kokubo, William E. B. Johnson, Akihiko Matsumine
Publikováno v:
Cell Transplantation, Vol 27 (2018)
The use of mesenchymal stromal cell (MSC) transplantation to repair the injured spinal cord has shown consistent benefits in preclinical models. However, the low survival rate of grafted MSC is one of the most important problems. In the injured spina
Externí odkaz:
https://doaj.org/article/7e0fdb0b11854e0a8e6883023941b60f
Autor:
Ibtesam R. T. Al-Delfi, William E. B. Johnson, Takumi Sakamoto, Martyn Snow, Nupur Kohli, Tsuyoshi Miyazaki, Hideaki Nakajima, Kenzo Uchida
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
CD271 is a marker of bone marrow MSCs with enhanced differentiation capacity for bone or cartilage repair. However, the nature of CD271+ MSCs from adipose tissue (AT) is less well understood. Here, we investigated the differentiation, wound healing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3048151f4cf579dde498c3896b71f4
http://link.springer.com/article/10.1038/s41598-019-39715-z
http://link.springer.com/article/10.1038/s41598-019-39715-z
Publikováno v:
Biochimie. 155:26-36
The multifactorial complexity of spinal cord injuries includes the formation of a glial scar, of which chondroitin sulphated proteoglycans (CSPG) are an integral component. Previous studies have shown CSPG to have inhibitory effects on endothelial an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425891d0ebcdcc9ad9f0acbabf41397e
https://doi.org/10.1016/j.biochi.2018.04.011
https://doi.org/10.1016/j.biochi.2018.04.011
Autor:
Laura Lossi, John F. Innes, William E. B. Johnson, Francesco Ferrini, Chelsea R. Wood, Adalberto Merighi, Esri H. Juárez, Peter Myint
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 26, Iss, Pp 100976-(2021)
Biochemistry and Biophysics Reports, Vol 26, Iss, Pp 100976-(2021)
Ex vivo spinal cord slice cultures (SCSC) allow study of spinal cord circuitry, maintaining stimuli responses comparable to live animals. Previously, we have shown that mesenchymal stem/stromal cell (MSC) transplantation in vivo reduced inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7737cb7f93c555917756e0aa9528bf0
http://europepmc.org/articles/PMC7933697
http://europepmc.org/articles/PMC7933697
Autor:
William E. B. Johnson
Publikováno v:
Emerging Topics in Life Sciences
This special issue of Emerging Topics in Life Sciences entitled ‘Current Topics in Stem Cells and Regenerative Medicine’ brings together expertise from a collaborative organisation known as the Mercia Stem Cell Alliance (MSCA). The alliance was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e830b3e8dbe7617a6e0f2ae35e9cba2
https://doi.org/10.1042/etls20210264
https://doi.org/10.1042/etls20210264
Autor:
William E. B. Johnson, Christopher M. Bunce, Martyn D. Snow, Max A Ellington, Andrew D. Southam, Hannah L. Mackay, Jonathan Sheard, Farhat L. Khanim
Publikováno v:
Bioscience Reports
Drug repurposing is a cost-effective means of targeting new therapies for cancer. We have examined the effects of the repurposed drugs, bezafibrate, medroxyprogesterone acetate and valproic acid on human osteosarcoma cells, i.e., SAOS2 and MG63 compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286e5918a0eefae4b0ec0ec75d7f59e8
https://doi.org/10.1042/bsr20202505
https://doi.org/10.1042/bsr20202505
Autor:
J.R. Chowdhury, Aheed Osman, Karina T. Wright, William E. B. Johnson, Sharon J. Brown, Naveen Kumar, Charlotte H Hulme, Heidi R. Fuller, John S. Riddell
Publikováno v:
Spinal Cord. 55:114-125
Study design:\ud \ud Review study.\ud \ud Objectives:\ud \ud The identification of prognostic biomarkers of spinal cord injury (SCI) will help to assign SCI patients to the correct treatment and rehabilitation regimes. Further, the detection of bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6734f1abfb3479d4c2ccfeea53e9f969
https://doi.org/10.1038/sc.2016.174
https://doi.org/10.1038/sc.2016.174
Autor:
Chelsea R. Wood, Ibtesam Al-Delfi, D.B. Haddow, D. Al Dhahri, Anthony Worthington, Rachel L. Sammons, William E. B. Johnson
Publikováno v:
International Journal of Experimental Pathology. 97:A1-A28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d95b28d7c0fc24d424133053658086
https://doi.org/10.1111/iep.12211
https://doi.org/10.1111/iep.12211