Zobrazeno 1 - 10
of 510
pro vyhledávání: '"William E Klunk"'
Autor:
Mark Mapstone, Thomas J Gross, Fabio Macciardi, Amrita K Cheema, Melissa Petersen, Elizabeth Head, Benjamin L Handen, William E Klunk, Bradley T Christian, Wayne Silverman, Ira T Lott, Nicole Schupf, for the Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Disruption of metabolic function is a recognized feature of late onset Alzheimer's disease (LOAD). We sought to determine whether similar metabolic pathways are implicated in adults with Down syndrome (DS) who have increased ris
Externí odkaz:
https://doaj.org/article/f84990f465ff493aa63689665c43d389
Autor:
Xuemei Zeng, Tara K. Lafferty, Anuradha Sehrawat, Yijun Chen, Pamela C. L. Ferreira, Bruna Bellaver, Guilherme Povala, M. Ilyas Kamboh, William E. Klunk, Ann D. Cohen, Oscar L. Lopez, Milos D. Ikonomovic, Tharick A. Pascoal, Mary Ganguli, Victor L. Villemagne, Beth E. Snitz, Thomas K. Karikari
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Blood-based biomarkers are gaining grounds for the detection of Alzheimer’s disease (AD) and related disorders (ADRDs). However, two key obstacles remain: the lack of methods for multi-analyte assessments and the need for biomar
Externí odkaz:
https://doaj.org/article/c51e1a14802e4f3799358b5410df0e5b
Autor:
Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K. Lafferty, Julia Kofler, Sarah B. Berman, Robert A. Sweet, Dana L. Tudorascu, William E. Klunk, Milos D. Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E. Snitz, Anne D. Cohen, Victor L. Villemagne, Tharick A. Pascoal, M. llyas Kamboh, Oscar I. Lopez, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)
Abstract Alzheimer’s disease (AD), the most common form of dementia, remains challenging to understand and treat despite decades of research and clinical investigation. This might be partly due to a lack of widely available and cost-effective modal
Externí odkaz:
https://doaj.org/article/64c9dbe829a54f7ea0148397b7f5ae86
Autor:
Yi Su, Tyler M Blazey, Christopher J Owen, Jon J Christensen, Karl Friedrichsen, Nelly Joseph-Mathurin, Qing Wang, Russ C Hornbeck, Beau M Ances, Abraham Z Snyder, Lisa A Cash, Robert A Koeppe, William E Klunk, Douglas Galasko, Adam M Brickman, Eric McDade, John M Ringman, Paul M Thompson, Andrew J Saykin, Bernardino Ghetti, Reisa A Sperling, Keith A Johnson, Stephen P Salloway, Peter R Schofield, Colin L Masters, Victor L Villemagne, Nick C Fox, Stefan Förster, Kewei Chen, Eric M Reiman, Chengjie Xiong, Daniel S Marcus, Michael W Weiner, John C Morris, Randall J Bateman, Tammie L S Benzinger, Dominantly Inherited Alzheimer Network
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152082 (2016)
Amyloid imaging plays an important role in the research and diagnosis of dementing disorders. Substantial variation in quantitative methods to measure brain amyloid burden exists in the field. The aim of this work is to investigate the impact of meth
Externí odkaz:
https://doaj.org/article/3c1e448b15fa468cb6de83c58a76a317
Autor:
Yi Su, Tyler M Blazey, Christopher J Owen, Jon J Christensen, Karl Friedrichsen, Nelly Joseph-Mathurin, Qing Wang, Russ C Hornbeck, Beau M Ances, Abraham Z Snyder, Lisa A Cash, Robert A Koeppe, William E Klunk, Douglas Galasko, Adam M Brickman, Eric McDade, John M Ringman, Paul M Thompson, Andrew J Saykin, Bernardino Ghetti, Reisa A Sperling, Keith A Johnson, Stephen P Salloway, Peter R Schofield, Colin L Masters, Victor L Villemagne, Nick C Fox, Stefan Förster, Kewei Chen, Eric M Reiman, Chengjie Xiong, Daniel S Marcus, Michael W Weiner, John C Morris, Randall J Bateman, Tammie L S Benzinger, Dominantly Inherited Alzheimer Network
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163669 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0152082.].
Externí odkaz:
https://doaj.org/article/34776afea7e04c56aaf53449f4d482fc
Autor:
Yi Su, Shaney Flores, Guoqiao Wang, Russ C. Hornbeck, Benjamin Speidel, Nelly Joseph‐Mathurin, Andrei G. Vlassenko, Brian A. Gordon, Robert A. Koeppe, William E. Klunk, Clifford R. Jack Jr., Martin R. Farlow, Stephen Salloway, Barbara J. Snider, Sarah B. Berman, Erik D. Roberson, Jared Brosch, Ivonne Jimenez‐Velazques, Christopher H. vanDyck, Douglas Galasko, Shauna H. Yuan, Suman Jayadev, Lawrence S. Honig, Serge Gauthier, Ging‐Yuek R. Hsiung, Mario Masellis, William S. Brooks, Michael Fulham, Roger Clarnette, Colin L. Masters, David Wallon, Didier Hannequin, Bruno Dubois, Jeremie Pariente, Raquel Sanchez‐Valle, Catherine Mummery, John M. Ringman, Michel Bottlaender, Gregory Klein, Smiljana Milosavljevic‐Ristic, Eric McDade, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 180-190 (2019)
Abstract Introduction Quantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. Th
Externí odkaz:
https://doaj.org/article/6e1734993f954447b3409ef075057895
Autor:
Cécile Tissot, Stijn Servaes, Firoza Z. Lussier, João Pedro Ferrari-Souza, Joseph Therriault, Pâmela C.L. Ferreira, Gleb Bezgin, Bruna Bellaver, Douglas Teixeira Leffa, Sulantha S. Mathotaarachchi, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita-Poltronetti, Yi-Ting Wang, Jaime Fernandez-Arias, Andrea L. Benedet, Eduardo R. Zimmer, Jean-Paul Soucy, Dana L. Tudorascu, Annie D. Cohen, Madeleine Sharp, Serge Gauthier, Gassan Massarweh, Brian Lopresti, William E. Klunk, Suzanne L. Baker, Victor L. Villemagne, Pedro Rosa-Neto, Tharick A. Pascoal
Publikováno v:
Journal of Nuclear Medicine. 64:452-459
Autor:
Yi Su, Shaney Flores, Russ C. Hornbeck, Benjamin Speidel, Andrei G. Vlassenko, Brian A. Gordon, Robert A. Koeppe, William E. Klunk, Chengjie Xiong, John C. Morris, Tammie L.S. Benzinger
Publikováno v:
NeuroImage: Clinical, Vol 19, Iss , Pp 406-416 (2018)
Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. Successful use of this tool is limited by the lack of a common standard in the quantification of amyloid imaging data. The Centiloid approach was recently proposed
Externí odkaz:
https://doaj.org/article/600d9461ce0745e5be5092203d080754
Autor:
Dana L. Tudorascu, Davneet S. Minhas, Patrick J. Lao, Tobey J. Betthauser, Zheming Yu, Charles M. Laymon, Brian J. Lopresti, Chet A. Mathis, William E. Klunk, Benjamin L. Handen, Bradley T. Christian, Ann D. Cohen
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 332-339 (2018)
Abstract Introduction Centiloid standardization was developed to establish a quantitative outcome measure of amyloid burden that could accommodate the integration of different amyloid positron emission tomography radiotracers or different methods of
Externí odkaz:
https://doaj.org/article/8ffce269e76747aa96cf606a131501e4
Autor:
Bruna Bellaver, Guilherme Povala, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Andréa L. Benedet, Nicholas J. Ashton, Gallen Triana-Baltzer, Hartmuth C. Kolb, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar L. Lopez, Dana L. Tudorascu, Victor L. Villemagne, Milos D. Ikonomovic, Serge Gauthier, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Howard J. Aizenstein, William E. Klunk, Beth E. Snitz, Pauline Maki, Rebecca C. Thurston, Ann D. Cohen, Mary Ganguli, Thomas K. Karikari, Pedro Rosa-Neto, Tharick A. Pascoal
Publikováno v:
Nature Medicine.
An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, co