Zobrazeno 1 - 10
of 239
pro vyhledávání: '"William E Gillanders"'
Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1.
Autor:
Fatma A Omar, Taylor C Brown, William E Gillanders, Timothy P Fleming, Michael A Smith, Ross M Bremner, Narendra V Sankpal
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285707 (2023)
Next generation sequencing of human cancer mutations has identified novel therapeutic targets. Activating Ras oncogene mutations play a central role in oncogenesis, and Ras-driven tumorigenesis upregulates an array of genes and signaling cascades tha
Externí odkaz:
https://doaj.org/article/829f1e9066864c72ad1fb7a926411f03
Autor:
Foluso O. Ademuyiwa, Feng Gao, Cherease R. Street, Ina Chen, Donald W. Northfelt, Robert Wesolowski, Mili Arora, Adam Brufsky, E. Claire Dees, Cesar A. Santa-Maria, Roisin M. Connolly, Jeremy Force, Alvaro Moreno-Aspitia, John M. Herndon, Madelyn Carmody, Sherri R. Davies, Sarah Larson, Kathleen L. Pfaff, Stephanie M. Jones, Jason L. Weirather, Anita Giobbie-Hurder, Scott J. Rodig, Zheng Liu, Ian S. Hagemann, Elad Sharon, William E. Gillanders
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Atezolizumab with chemotherapy has shown improved progression-free and overall survival in patients with metastatic PD-L1 positive triple negative breast cancer (TNBC). Atezolizumab with anthracycline- and taxane-based neoadjuvant chemothera
Externí odkaz:
https://doaj.org/article/d2b06f8f41a040519a09fe040f35b01e
Autor:
Hui Peng, Lijin Li, Chong Zuo, Michael Y. Chen, Xiuli Zhang, Nancy B. Myers, Graham D. Hogg, David G. DeNardo, S. Peter Goedegebuure, William G. Hawkins, William E. Gillanders
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundCancer neoantigens are important targets of cancer immunotherapy and neoantigen vaccines are currently in development in pancreatic ductal adenocarcinoma (PDAC) and other cancer types. Immune regulatory mechanisms in pancreatic cancer may l
Externí odkaz:
https://doaj.org/article/0e3fe50aa4d44130bd63e7763d67c6e4
Autor:
Narendra V. Sankpal, Taylor C. Brown, Timothy P. Fleming, John M. Herndon, Anusha A. Amaravati, Allison N. Loynd, William E. Gillanders
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. It was recently demon
Externí odkaz:
https://doaj.org/article/38b6284507a6410392762012b6929067
Autor:
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufac
Externí odkaz:
https://doaj.org/article/031af79ff43e4bff85ce49e20a87cccb
Autor:
Abigail Tremelling, Rebecca L. Aft, Amy E. Cyr, William E. Gillanders, Katherine Glover‐Collins, Virginia Herrmann, Julie A. Margenthaler
Publikováno v:
Cancer Reports, Vol 5, Iss 5, Pp n/a-n/a (2022)
Abstract Background Consensus guidelines published in 2016 recommended a 2 mm free margin as the standard for negative margins in patients undergoing breast‐conserving surgery (BCS) for ductal carcinoma in situ (DCIS). The goal of the guideline rec
Externí odkaz:
https://doaj.org/article/9f17e44510a44813bb5e488b93e6c73d
Autor:
C. Corbin Frye, Sai Anusha Sanka, Janessa Sullivan, L. Michael Brunt, William E. Gillanders, T.K. Pandian, Taylor C. Brown
Publikováno v:
Journal of Surgical Research. 288:148-156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb69957c033f41b4089c268cdc10e8ff
https://doi.org/10.1016/j.jss.2023.02.011
https://doi.org/10.1016/j.jss.2023.02.011
Autor:
Megan M. Richters, Huiming Xia, Katie M. Campbell, William E. Gillanders, Obi L. Griffith, Malachi Griffith
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-21 (2019)
Abstract Neoantigens are newly formed peptides created from somatic mutations that are capable of inducing tumor-specific T cell recognition. Recently, researchers and clinicians have leveraged next generation sequencing technologies to identify neoa
Externí odkaz:
https://doaj.org/article/1ba0106236d94549b59495df324a8b82
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 956 (2021)
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in epithelial tissues. EpCAM forms intercellular, homophilic adhesions, modulates epithelial junctional protein complex formation, and promotes epithelial tissue home
Externí odkaz:
https://doaj.org/article/bcfe10d6a7044c229f950c299b289c91
Autor:
Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Gavin P. Dunn
Publikováno v:
OncoImmunology, Vol 8, Iss 4 (2019)
Neoantigens represent promising targets for personalized cancer vaccine strategies. However, the feasibility of this approach in lower mutational burden tumors like glioblastoma (GBM) remains unknown. We have previously reported the use of an immunog
Externí odkaz:
https://doaj.org/article/8dde9e453942466c919f33fd089ee9d6