Zobrazeno 1 - 10
of 82
pro vyhledávání: '"William E Fitzsimmons"'
Autor:
Luke Kosinski, Eric Frey, Amanda Klein, Inish O'Doherty, Klaus Romero, Mark Stegall, Ilkka Helanterä, Ahmed Osama Gaber, William E. Fitzsimmons, Varun Aggarwal, Transplant Therapeutics Consortium (TTC)
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1680-1690 (2023)
Abstract Kidney transplantation is the preferred treatment for individuals with end‐stage kidney disease. From a modeling perspective, our understanding of kidney function trajectories after transplantation remains limited. Current modeling of kidn
Externí odkaz:
https://doaj.org/article/7241a41580864d65a17bfe904e44574e
Qualifying a Novel Clinical Trial Endpoint (iBOX) Predictive of Long-Term Kidney Transplant Outcomes
Autor:
Amanda Klein, Alexandre Loupy, Mark Stegall, Ilkka Helanterä, Luke Kosinski, Eric Frey, Olivier Aubert, Gillian Divard, Kenneth Newell, Herwig-Ulf Meier-Kriesche, Roslyn Mannon, Thomas Dumortier, Varun Aggarwal, Jagdeep T. Podichetty, Inish O’Doherty, Ahmed Osama Gaber, William E. Fitzsimmons
Publikováno v:
Transplant International, Vol 36 (2023)
New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute’s Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel secondary ef
Externí odkaz:
https://doaj.org/article/30625a9a0ea742bbb206416f92a9eb5a
Autor:
William E. Fitzsimmons
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022)
Individuals who experience severe COVID-19-vaccine-related adverse reactions such as transverse myelitis may be precluded from receiving further vaccination to protect from SARS-CoV-2 infection. Although the mechanism of autoimmune spinal cord inflam
Externí odkaz:
https://doaj.org/article/7a2cb4a6e6704e89b8734a9cbe93e20f
BackgroundHealth care inequity includes the lack of adequate representation of various populations in clinical trials. Government, academic and industry organizations have highlighted these issues and committed to actions to improve. In order to asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20e91f01a962363946b2e0820541e4a3
https://doi.org/10.1101/2023.05.11.23289884
https://doi.org/10.1101/2023.05.11.23289884
FKBP, a naturally occurring ubiquitous intracellular protein, has been proposed as a potential target for coronavirus replication. A non-immunosuppressive FKBP ligand, FK1706, was studied in vitro in a Vero cell model to assess potential activity alo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917ccf899b4e5a98fac660ef8c4f0e95
https://doi.org/10.1101/2022.02.03.479080
https://doi.org/10.1101/2022.02.03.479080
Autor:
Jay Erdman, Josephine Wolfram, David Nimke, Richard Croy, Xuegong Wang, Tim Weaver, David Schladt, William E. Fitzsimmons
Publikováno v:
Transplantation. 106(6)
The Scientific Registry of Transplant Recipients was retrospectively analyzed to provide real-world evidence of the efficacy and safety of tacrolimus-based immunosuppressive regimens in adult lung transplant recipients in the United States.Adult reci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49521447d2112c8c597047cbe9b97fc
https://pubmed.ncbi.nlm.nih.gov/34974456
https://pubmed.ncbi.nlm.nih.gov/34974456
Publikováno v:
Therapeutic Innovation & Regulatory Science
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdeefd178c8e138a228e7ae9eaa7185f
https://pubmed.ncbi.nlm.nih.gov/33094425
https://pubmed.ncbi.nlm.nih.gov/33094425
Autor:
Marie A. Chisholm-Burns, Renata Albrecht, Robert Ettenger, Pujita Vaidya, Rita R. Alloway, William E. Fitzsimmons, Peter Nickerson, Ozlem A Belen, Mary Amanda Dew, Graham Thompson, Cavaille-Coll M
Publikováno v:
American Journal of Transplantation. 18:564-573
The Food and Drug Administration (FDA) held a public meeting and scientific workshop in September 2016 to obtain perspectives from solid organ transplant recipients, family caregivers, and other patient representatives. The morning sessions focused o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb035bc38dfb17e001bf9e3c3ff38054
https://doi.org/10.1111/ajt.14635
https://doi.org/10.1111/ajt.14635
Autor:
M. Roy First, Maria G. Tanzi, James Keirns, Malcolm Brown, Nasrullah Undre, William E. Fitzsimmons
Publikováno v:
Clinical transplantation. 30(8)
Prolonged-release tacrolimus was developed as a once-daily formulation with ethylcellulose as the excipient, resulting in slower release and reduction in peak concentration (Cmax ) for a given dose compared with immediate-release tacrolimus, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f3d8d926a5a6e9971abc3a5cd7f499
https://pubmed.ncbi.nlm.nih.gov/27220013
https://pubmed.ncbi.nlm.nih.gov/27220013
Autor:
William E. Fitzsimmons
Publikováno v:
Immunotherapy in Transplantation. :224-240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::367590c7bf71bb067ba089ec3ca6e188
https://doi.org/10.1002/9781444355628.ch16
https://doi.org/10.1002/9781444355628.ch16