Zobrazeno 1 - 10
of 87
pro vyhledávání: '"William E Farrell"'
Autor:
Vasileios A Stamelos, Natalie Fisher, Harnoor Bamrah, Carolyn Voisey, Joshua C Price, William E Farrell, Charles W Redman, Alan Richardson
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150696 (2016)
Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that
Externí odkaz:
https://doaj.org/article/fe841501bcc54322968b98bf7bd8bc13
Autor:
Mark O Kitchen, Richard T Bryan, Kim E Haworth, Richard D Emes, Christopher Luscombe, Lyndon Gommersall, K K Cheng, Maurice P Zeegers, Nicholas D James, Adam J Devall, Anthony A Fryer, William E Farrell
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137003 (2015)
Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder cancer (NMIBC
Externí odkaz:
https://doaj.org/article/a3cf01557fcd480eb56ec7eac1474195
Autor:
Pensee Wu, William E. Farrell, Kim E. Haworth, Richard D. Emes, Mark O. Kitchen, John R. Glossop, Fahmy W. Hanna, Anthony A. Fryer
Publikováno v:
Epigenetics, Vol 13, Iss 2, Pp 122-128 (2018)
Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to det
Externí odkaz:
https://doaj.org/article/e67709eef8914d9cb025ab6610835e8a
DNA methylation at promoter CpG islands (CGI) is an epigenetic modification associated with inappropriate gene silencing in multiple tumor types. In the absence of a human pituitary tumor cell line, small interfering RNA–mediated knockdown of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56a78ac405b447c5e555ce511d08e13d
https://doi.org/10.1158/1541-7786.c.6541483
https://doi.org/10.1158/1541-7786.c.6541483
Supplementary Tables S1-S2 from Genome-Wide Analysis in a Murine Dnmt1 Knockdown Model Identifies Epigenetically Silenced Genes in Primary Human Pituitary Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508e184b01f2d1ff02e3f2507be2fd2b
https://doi.org/10.1158/1541-7786.22516774
https://doi.org/10.1158/1541-7786.22516774
Autor:
William E. Farrell, Richard D. Emes, Pensee Wu, John R Glossop, Anthony A. Fryer, Fahmy W F Hanna, Kim E. Haworth, Mark O. Kitchen
Publikováno v:
Epigenetics. 13:122-128
Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450Karray analysis to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b81b7709dc1e24fe90516a89557b43
https://doi.org/10.1080/15592294.2016.1166321
https://doi.org/10.1080/15592294.2016.1166321
Autor:
Maurice P. Zeegers, Richard T. Bryan, Nicholas D. James, Anthony A. Fryer, John R Glossop, Richard D. Emes, Kar Keung Cheng, Christopher Luscombe, Charles A. Mein, Adam J. Devall, William E. Farrell, Lyndon Gommersall, Mark O. Kitchen
Publikováno v:
Epigenetics, 11(3), 237-246. Landes Bioscience
High-grade non-muscle invasive bladder cancer (HG-NMIBC) is a clinically unpredictable disease with greater risks of recurrence and progression relative to their low-intermediate-grade counterparts. The molecular events, including those affecting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec97c85e88583704c19f285b5899afac
https://doi.org/10.1080/15592294.2016.1154246
https://doi.org/10.1080/15592294.2016.1154246
Autor:
William E. Farrell, Nicola B Nixon, Jon Packham, Richard D. Emes, John R Glossop, Anthony A. Fryer, Derek L. Mattey
Publikováno v:
Epigenomics. 8:209-224
Aim: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease. Following recent investigations of T and B lymphocytes in established disease, we now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea10850eab12bc67d1cb9cdac4d350c
https://doi.org/10.2217/epi.15.103
https://doi.org/10.2217/epi.15.103
Autor:
Fadime Dogan, Leo J. Hofland, Richard A Feelders, Marije J. Veenstra, Steven W. J. Lamberts, Peter M. van Koetsveld, Wouter W. de Herder, Giovanni Vitale, William E. Farrell
Publikováno v:
Oncotarget, 9(19), 14791-14802. Impact Journals LLC
Oncotarget
Oncotarget
// Marije J. Veenstra 1 , Peter M. van Koetsveld 1 , Fadime Dogan 1 , William E. Farrell 2 , Richard A. Feelders 1 , Steven W.J. Lamberts 1 , Wouter W. de Herder 1 , Giovanni Vitale 3, 4 , Leo J. Hofland 1 1 Department of Internal Medicine, Division
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48b46d1bf5c111a754ff476c8b6af98
https://pure.eur.nl/en/publications/4cf210d0-4495-4986-ab7c-ed4e2ea18da4
https://pure.eur.nl/en/publications/4cf210d0-4495-4986-ab7c-ed4e2ea18da4
Autor:
Paraskevi Xekouki, Natalia Strebkova, Eva Szarek, Leonor Palmeira, Isaac Levy, James R. Lupski, William E. Farrell, Mauricette Jamar, Peter Kamenický, Catherine S. Choong, Maria Chiara Zatelli, Stanko S. Stojilkovic, Emanuele Ferrante, Rodrigo Bertollo de Alexandre, Stefano Costanzi, Leticia F Leal, Darwin O. Larco, Aggeliki Dimopoulos, Emilie Castermans, Philippe Chanson, Giampaolo Trivellin, Albert Beckers, Luciana Ansaneli Naves, Wouter Coppieters, Allison D. Manning, Jérôme Bertherat, Liliya Rostomyan, Maria de la Luz Sierra, Vincent Bours, Bo Yuan, Constantine A. Stratakis, Nadia Mazerkina, Martha Quezado, Prashant Chittiboina, Anne Barlier, Chiara Villa, T. John Wu, Jürgen Wess, Anelia Horvath, Michel Georges, Fabio R. Faucz, Daniel Metzger, Philippe A. Lysy, Ivana Bjelobaba, Jean-Hubert Caberg, Adrian Daly, Pengfei Liu, Marie Helene Schernthaner-Reiter, Margaret F. Keil, Maya Lodish, Nalini S. Shah
Publikováno v:
New England Journal of Medicine. 371:2363-2374
BACKGROUND: Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. METHODS: We performed clinical and genetic studies of samples obtained fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038c6565b6bb63d4bb071b5a48c0829b
https://doi.org/10.1056/nejmoa1408028
https://doi.org/10.1056/nejmoa1408028