Zobrazeno 1 - 10
of 31
pro vyhledávání: '"William E, Zackert"'
Autor:
Elena Matafonova, Valery Yermalitsky, L. Jackson Roberts, Zhuoheng Li, Keri A. Tallman, William E. Zackert, Venkataraman Amarnath, Sean S. Davies
Publikováno v:
Analytical Biochemistry. 566:89-101
Isolevuglandins (IsoLGs) are a family of highly reactive 4-ketoaldehydes formed by lipid peroxidation that modify the lysyl residues of cellular proteins. Modification of proteins by IsoLGs have been shown to contribute to disease processes such as t
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 8, Pp 1589-1593 (1998)
D2/E2-isoprostanes are prostaglandin D2/E2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid. One E2-isoprostane that should be formed is 15-E2t-isoprostane (8-iso-prostaglan
Externí odkaz:
https://doaj.org/article/b912a7fbd7ca4a1da42b22b647991bca
Autor:
James M. May, William E. Zackert, Sergey Dikalov, Aurelia Vergeade, L. Jackson Roberts, Alfiya Bikineyeva, Clinton C. Bertram, Olivier Boutaud, Sandra S. Zinkel
Publikováno v:
Mitochondrion. 28:88-95
Modifications of cardiolipin (CL) levels or compositions are associated with changes in mitochondrial function in a wide range of pathologies. We have made the discovery that acetaminophen remodels CL fatty acids composition from tetralinoleoyl to li
Publikováno v:
Free Radical Biology and Medicine. 59:36-44
F2-Isoprostanes (IsoPs) are isomers of prostaglandin F2α formed from the nonenzymatic free radical-catalyzed peroxidation of arachidonic acid. Since discovery of these molecules by Morrow and Roberts in 1990, F2-IsoPs have been shown to be excellent
Autor:
James West, Samuel W. Caito, Joshua P. Fessel, Thuy T. Nguyen, L. Jackson Roberts, Michael Aschner, William E. Zackert, Shijun Zhu
Publikováno v:
Aging (Albany NY)
Isoketals (IsoKs) are highly reactive γ-ketoaldehyde products of lipid peroxidation that covalently adduct lysine side chains in proteins, impairing their function. Using C. elegans as a model organism, we sought to test the hypothesis that IsoKs co
Autor:
William E. Zackert, Jonathan A. Kropski, Michael L. Freeman, Pierre P. Massion, L. Jackson Roberts Second, Raymond L. Mernaugh, James J. Galligan, Sean S. Davies, W. Hayes McDonald, Timothy S. Blackwell, Elizabeth L. Travis, Konjeti R. Sekhar, Lawrence J. Marnett, Stacey Mont, Brahm H. Segal
Publikováno v:
Scientific Reports
Protein lysine modification by γ-ketoaldehyde isomers derived from arachidonic acid, termed isolevuglandins (IsoLGs), is emerging as a mechanistic link between pathogenic reactive oxygen species and disease progression. However, the questions of whe
Autor:
Ling Gao, Huiyong Yin, Catha Remmert, Sudhansu K. Dey, William E. Zackert, Jason D. Morrow, Ned A. Porter, Michael E. Danekis, Jeff Reese, Justin J. Hasford, Ginger L. Milne, Hsin Hsiung Tai
Publikováno v:
Journal of Biological Chemistry. 278:28479-28489
It has heretofore been assumed that the cyclooxygenases (COXs) are solely responsible for peostaglandin (PG) synthesis in vivo. An important structural feature of PGH2 formed by COX is the trans-configuration of side chains relative to the prostane r
Autor:
William E. Zackert, Olivier Boutaud, Rebecca Chinery, Ramona Graves-Deal, Laine J. Murphey, John A. Oates, Jason D. Morrow, Brian E. Cox, Robert J. Coffey
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1584:37-45
Cyclopentenone prostaglandins (PGs), particularly those of the J-series, affect proliferation and differentiation in a number of cell lines. J-ring PGs have been shown to be ligands for the peroxisome proliferator-activated receptor (PPAR)-gamma and
Autor:
Ginger L. Milne, Thomas J. Montine, Ned A. Porter, Laine J. Murphey, William E. Zackert, Jason D. Morrow, Samuel S. Fam, Yan Chen, Erin S. Terry, Saurabh Pandalai, L. Jackson Roberts, Ling Gao
Publikováno v:
Journal of Biological Chemistry. 277:36076-36084
Free radical-initiated oxidant injury and lipid peroxidation have been implicated in a number of neural disorders. Docosahexaenoic acid is the most abundant unsaturated fatty acid in the central nervous system. We have shown previously that this 22-c
Publikováno v:
Clinica Chimica Acta. 314:93-99
Background : The F 2 -isoprostanes (IsoPs) are a series of novel prostaglandin (PG)-like compounds generated from the free radical catalyzed peroxidation of arachidonic acid. One IsoP, 15-F 2t -IsoP (8-iso-PGF 2α ), has been shown to be formed in ab