Zobrazeno 1 - 10
of 248
pro vyhledávání: '"William E, Hoffman"'
Publikováno v:
Arquivos de Neuro-Psiquiatria, Vol 63, Iss 2a, Pp 339-344 (2005)
Occlusion or stenosis of a parent vessel or its distal branches is a major cause of poor patient outcome after cerebral aneurysm surgery. Despite great attempts to preserve patency at the time of clip application, intraoperative visual observation ma
Externí odkaz:
https://doaj.org/article/8ac67d26361242fc83e0c6d85fa6385e
Autor:
Kimberly F. Fennell, Zhijun Kang, Hirokazu Ueno, William E. Hoffman, Mihály Hajós, Thomas Allen Chappie, Mary Piotrowski, Noha Maklad, Jayvardhan Pandit, John M. Humphrey, Anne W. Schmidt, Edward X. Yang, Patrick Robert Verhoest, Bethany L. Kormos, Jiemin Lu, Eric P. Arnold, Cheng Chang, Christopher J. Schmidt, Robin J. Kleiman, Rebecca E. O’Connor, John F. Harms, Scot Richard Mente, Christopher John Helal, Tracey Boyden, Chewah Lee, Laura McDowell, Michael D. Forman
Publikováno v:
Journal of Medicinal Chemistry. 60:5673-5698
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify potent PDE2A inhibitors with improved brain pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146c156bc1785305e9a93e6cd8b6147
https://doi.org/10.1021/acs.jmedchem.7b00397
https://doi.org/10.1021/acs.jmedchem.7b00397
Autor:
Christopher J. Helal, Eric P. Arnold, Tracey L. Boyden, Cheng Chang, Thomas A. Chappie, Kimberly F. Fennell, Michael D. Forman, Mihaly Hajos, John F. Harms, William E. Hoffman, John M. Humphrey, Zhijun Kang, Robin J. Kleiman, Bethany L. Kormos, Erik A. LaChapelle, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E. O’Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W. Schmidt, Christopher J. Schmidt, Hirokazu Ueno, Patrick R. Verhoest, Edward X. Yang
Publikováno v:
Journal of medicinal chemistry. 61(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284ec23899d97800205ac23dc80d4562
https://pubmed.ncbi.nlm.nih.gov/28574706
https://pubmed.ncbi.nlm.nih.gov/28574706
Autor:
Mihály Hajós, William E. Hoffman, John F. Harms, Mary Piotrowski, Christopher J. Schmidt, Eric P. Arnold, Robin J. Kleiman, Edward X. Yang, Adam Ogden, Patricia A. Seymour, Jiemin Lu, Ethan Lawrence Fisher, Nichole Vansell, Patrick Robert Verhoest, Jayvardhan Pandit, Zhijun Kang, Hirokazu Ueno, John M. Humphrey, Bethany L. Kormos, Dina McGinnis, Thomas Allen Chappie, Noha Maklad, Laura McDowell, Cheng Chang, Rebecca E. O’Connor, Chewah Lee, Tracey Boyden, Christopher J. O’Donnell, Christopher John Helal
Publikováno v:
Journal of medicinal chemistry. 61(3)
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The analog PF-05180999 (30) was subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408cc7b21c310fe120ce681146fe8fb5
https://pubmed.ncbi.nlm.nih.gov/29293004
https://pubmed.ncbi.nlm.nih.gov/29293004
Publikováno v:
International Journal of Clinical Medicine. :328-331
The safety and efficacy of the laryngeal mask airway (LMA) has been reported by numerous large-scale studies. However, they do not address the issue of whether an intravenous (IV) is required for pediatric general anesthesia (GA) where access is chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e3d8c04d11d7d6a2a377c52291d82c8
https://doi.org/10.4236/ijcm.2011.23057
https://doi.org/10.4236/ijcm.2011.23057
The Impact of Group-as-a-Whole Work on Anxiety and Depression in a Severely Mentally Ill Population∗
Publikováno v:
The Journal for Specialists in Group Work. 33:43-60
This study explored the impact of a group-as-a-whole processing group on 11 severely mentally ill adult clients residing in a long term care facility over 30 weeks. Participants were evaluated for the effect of the group on anxiety and depression, us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ffcfde16003471d764e287afb8c5353
https://doi.org/10.1080/01933920701798554
https://doi.org/10.1080/01933920701798554
Publikováno v:
Anesthesia Progress. 54:170-174
We assessed the safety of general anesthesia for dental treatment of special needs patients as it related to American Society of Anesthesiology Physical Status (ASAPS) classification, procedure, and other factors. After Institutional Review Board rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995cadd629ba292080c2848b5daa3b99
https://doi.org/10.2344/0003-3006(2007)54[170:fyosod]2.0.co
https://doi.org/10.2344/0003-3006(2007)54[170:fyosod]2.0.co
Autor:
William E. Hoffman, Chanannait Paisansathan, Rodolfo G. Gatto, Verna L. Baughman, Fady T. Charbel, Mark Mueller
Publikováno v:
European Journal of Anaesthesiology. 24:1016-1020
BACKGROUND AND OBJECTIVES The purpose of this study was to determine whether brain oxyhaemoglobin-deoxyhaemoglobin coupling was altered by anaesthesia or intubation-induced stress. METHODS This was a prospective observational study in the operating r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21fb62f2a350206c369a4f345316f02
https://doi.org/10.1017/s0265021507000567
https://doi.org/10.1017/s0265021507000567
Publikováno v:
Journal of Clinical Monitoring and Computing. 21:265-269
Although intracranial tumors may affect autonomic function, there are few reports of autonomic changes during anesthesia. The purpose of this study was to evaluate autonomic effects of anesthesia in patients with brain tumors compared to neurosurgica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec03625b7ff6ae266c24c2332707ce65
https://doi.org/10.1007/s10877-007-9077-9
https://doi.org/10.1007/s10877-007-9077-9
