Zobrazeno 1 - 10
of 21
pro vyhledávání: '"William Dunker"'
Publikováno v:
Wildlife Society Bulletin, Vol 48, Iss 4, Pp n/a-n/a (2024)
Abstract Telemetry studies allow scientists to track animal movements and study species ecology without direct visual observation. Fitting telemetry devices requires physical or chemical capture and restraint of animals. Ground darting is a commonly
Externí odkaz:
https://doaj.org/article/030f15a651db4125bebea754ec45bf29
Autor:
Xiang Ye, Lindsey N. Guerin, Ziche Chen, Suba Rajendren, William Dunker, Yang Zhao, Ruilin Zhang, Emily Hodges, John Karijolich
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113888- (2024)
Summary: Higher-order genome structure influences the transcriptional regulation of cellular genes through the juxtaposition of regulatory elements, such as enhancers, close to promoters of target genes. While enhancer activation has emerged as an im
Externí odkaz:
https://doaj.org/article/81686b9dcf8f42048fee6a344ff48f21
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The Karijolich laboratory describes an atlas of A-to-I RNA editing during the KSHV lifecycle in primary effusion lymphoma. These analyses identified conserved editing events within a viral-encoded microRNA, revealing a critical role for the microRNA
Externí odkaz:
https://doaj.org/article/81c5c41ceaa2425ba38aeaa373d4d292
Autor:
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SR
Externí odkaz:
https://doaj.org/article/7052b61a50574159ad243b8dd55f38e5
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Cellular nonsense-mediated mRNA decay (NMD) has been shown to play a role in defense against RNA viruses. Here, Zhao et al. show that NMD restricts the DNA virus Kaposi sarcoma-associated herpesvirus (KSHV) via targeting both cellular and viral trans
Externí odkaz:
https://doaj.org/article/47378b33636d47899ccf826a68775637
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108976- (2021)
Summary: RIG-I-like receptors (RLRs) are involved in the discrimination of self versus non-self via the recognition of double-stranded RNA (dsRNA). Emerging evidence suggests that immunostimulatory dsRNAs are ubiquitously expressed but are disrupted
Externí odkaz:
https://doaj.org/article/9906c3ca83f34b41b6660475c6d2a76f
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
RIG-I and MDA5, are cytosolic restriction factors and receptors for RNA viruses. Here the authors show during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, sugg
Externí odkaz:
https://doaj.org/article/6190bab07a2545dbac95648005720f8c
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 6 (2018)
Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNA
Externí odkaz:
https://doaj.org/article/ec9bb0126c9647eeb5280c90597df755
Publikováno v:
Viruses, Vol 10, Iss 7, p 359 (2018)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus and the etiological agent of Kaposi’s sarcoma. KSHV is also causally associated with the development of lymphoproliferative diseases, including primary effusion lymphoma (
Externí odkaz:
https://doaj.org/article/37713109ddac41ea9c968b7ee485c943
Publikováno v:
Viruses, Vol 9, Iss 12, p 386 (2017)
Short interspersed elements (SINEs) are a family of retrotransposons evolutionarily derived from cellular RNA polymerase III transcripts. Over evolutionary time, SINEs have expanded throughout the human genome and today comprise ~11% of total chromos
Externí odkaz:
https://doaj.org/article/9dec91559620482f833f7bbdfbd04922