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pro vyhledávání: '"William Dubay"'
Autor:
Pamela Pollet, Charles L. Liotta, Kristen Kitagawa, Charles A. Eckert, Joy Stringer, Kent W. Richman, Kyle M. Flack, William Dubay
Publikováno v:
Organic Process Research & Development. 16:1301-1306
The Meerwein–Ponndorf–Verley (MPV) reduction of aldehydes and ketones has been the cornerstone in many multistep syntheses. Herein we report the use of Al(OtBu)3 instead of the commonly used Al(OiPr)3 which results in a dramatic rate increase and
Autor:
Charles L. Liotta, William Dubay, Reagan Charney, Pamela Pollet, Stuart H. Terett, Kent W. Richman, Elizabeth D. Cope, Joy Stringer, Charles A. Eckert, Michelle K. Kassner
Publikováno v:
Industrial & Engineering Chemistry Research. 48:7032-7036
N-Boc-(1S)-benzylhydroxy-3-chloropropylamine (6) is a precursor to pharmaceutically active compounds that act as human immunodeficiency virus (HIV) protease inhibitors. It is currently being produced via a batch process which includes a homologation
Autor:
Jeffrey D. Butler, Leslie T. Gelbaum, Charles L. Liotta, Carol Gelbaum, William Dubay, Pamela Pollet, William L. Heaner, Gregory Wells, Kent W. Richman
Publikováno v:
RSC Advances. 3:13232
A series of substituted indoles have been synthesized by the sequential reaction of aromatic aldehydes with ethyl azidoacetate in the presence of sodium ethoxide to form the corresponding ethyl α-azido-β-arylacrylates (Knoevenagel process) followed