Zobrazeno 1 - 10
of 38
pro vyhledávání: '"William Diamantis"'
Publikováno v:
Allergy. 48:230-235
Guinea pigs were sensitized and boostered with i.p. injections of ovalbumin (OA) 10 micrograms + Al(OH)3 100 mg. Thirteen days after the last injection animals (800-1100 g) were placed in bias flow ventilated whole body plethysmographs and allowed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c6fcc9a2c1de31aa4c7483a9fa4d89
https://doi.org/10.1111/j.1398-9995.1993.tb00721.x
https://doi.org/10.1111/j.1398-9995.1993.tb00721.x
Publikováno v:
Epilepsia. 34:367-371
Summary: The anticonvulsant effects of felbamate (FBM) alone or in combination with phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), or phenobarbital (PB) were investigated against maximal electroshock (MES) seizures in mice. Nonprotective dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3ce5aed7ecc2c6ab886748b59000b7
https://doi.org/10.1111/j.1528-1157.1993.tb02423.x
https://doi.org/10.1111/j.1528-1157.1993.tb02423.x
Autor:
William Diamantis, K K Wong, K. Nolan, N. Kucharczyk, J. Pivonka, C. N. Langevin, N. Chand, V E Adusumalli, R. D. Sofia, J. K. Wichmann
Publikováno v:
Allergy. 48:19-24
The correlation between the antiasthma activity of azelastine and the concentrations of azelastine and its major metabolite, desmethylazelastine, in the blood and lung were investigated in guinea pigs. Blood and lung tissue samples collected at 15 mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3cb77a0fe65239173f48dfe953d8db
https://doi.org/10.1111/j.1398-9995.1993.tb02170.x
https://doi.org/10.1111/j.1398-9995.1993.tb02170.x
Publikováno v:
Agents and Actions. 38:165-170
The mucolytic activity of azelastine, an antiallergic/antiasthmatic drug, in mice and rats was investigated. The oral administration of test compounds 30 min before phenol red i.p. injection stimulated dye secretion in the trachea of mice. The result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2020846bd470d60122e3a38e2c933b92
https://doi.org/10.1007/bf01976207
https://doi.org/10.1007/bf01976207
Publikováno v:
Agents and Actions. 37:184-187
Aeroallergen-induced dyspnea in guinea pigs was associated with an increase in amplitude in the box pressure fluctuations (212%) and pseudo-flow signal (604%) and an 80% decline (from 0.19 to 0.04 s) in relaxation time (the time it takes the box pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2262f435945313ef0346970d947f831d
https://doi.org/10.1007/bf02028104
https://doi.org/10.1007/bf02028104
Publikováno v:
Drug Development Research. 24:189-199
Acrihellin, digoxin, MDL 17043, and milrinone were administered intravenously in the anesthetized dog to compare their effects on the cardiovascular parameters following pentobarbital-induced heart failure. Dogs were instrumented to record left ventr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a7a7bd68bf71cfff8143b24c9fc72c1
https://doi.org/10.1002/ddr.430240206
https://doi.org/10.1002/ddr.430240206
Publikováno v:
British Journal of Pharmacology. 101:541-544
1. The exposure of rat isolated tracheal segment to the K(+)-channel inhibitor tetraethylammonium (TEA, 10 mM) for a period of 10-15 min generally produced little or no contractile response. 2. Cooling (10 C) provocation alone usually produced small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e25baee66605bddd4ec567a87e43250
https://doi.org/10.1111/j.1476-5381.1990.tb14117.x
https://doi.org/10.1111/j.1476-5381.1990.tb14117.x
Publikováno v:
International Archives of Allergy and Immunology. 91:311-314
Guinea pigs were sensitized by intraperitoneal injection of ovalbumin, 10 μg mixed with 100 mg Al(OH)3 in saline. On days 15–30 sensitized guinea pigs were challenged with ovalbumin aerosol (0.5 mg/ml, 30 s, 15 psi) which produced immediate asthma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d27b7445473339e687494d5acb400f
https://doi.org/10.1159/000235133
https://doi.org/10.1159/000235133
Publikováno v:
International Archives of Allergy and Immunology. 92:143-147
Azelastine produced a concentration-dependent inhibition of calcium ionophore A23187 (0.2 μM) stimulated generation of 5-HETE, leukotriene B4, and leukotriene C4 in rat mixed peritoneal cells, yielding IC50 values of 35.5,47.4, and 31.7 μM, respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd184034094c1c7ed5dda3658e53d28
https://doi.org/10.1159/000235205
https://doi.org/10.1159/000235205
Autor:
K. Nolan, Naresh Chand, J. E. Harrison, S. M. Rooney, William Diamantis, R. D. Sofia, J. Pillar, R. G. Jakubicki
Publikováno v:
European Journal of Pharmacology. 211:121-123
In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aeroal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5584a3a18b90a12c8e338c219afcf50
https://doi.org/10.1016/0014-2999(92)90273-7
https://doi.org/10.1016/0014-2999(92)90273-7