Zobrazeno 1 - 10
of 102
pro vyhledávání: '"William DeGraff"'
Autor:
Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Shun Kishimoto, Jonathan W Wojtkowiak, William DeGraff, Aparna H Kesarwala, Rajani Choudhuri, Nallathamby Devasahayam, Sankaran Subramanian, Jeeva P Munasinghe, Robert J Gillies, James B Mitchell, Charles P Hart, Murali C Krishna
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107995 (2014)
TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia
Externí odkaz:
https://doaj.org/article/0938aa4f3d55486b8f95bb9b28022c2c
Autor:
Anthony D. Saleh, Jason E. Savage, Liu Cao, Benjamin P. Soule, David Ly, William DeGraff, Curtis C. Harris, James B. Mitchell, Nicole L. Simone
Publikováno v:
PLoS ONE, Vol 7, Iss 4 (2012)
Externí odkaz:
https://doaj.org/article/361a1237f7da449ab55c98bb827fc767
Autor:
Anthony D Saleh, Jason E Savage, Liu Cao, Benjamin P Soule, David Ly, William DeGraff, Curtis C Harris, James B Mitchell, Nicole L Simone
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24429 (2011)
Genotoxic stressors, such as radiation, induce cellular damage that activates pre-programmed repair pathways, some of which involve microRNAs (miRNA) that alter gene expression. The let-7 family of miRNA regulates multiple cellular processes includin
Externí odkaz:
https://doaj.org/article/898530fedc164e3c9fe5d88c1f209525
Autor:
Nicole L Simone, Benjamin P Soule, David Ly, Anthony D Saleh, Jason E Savage, William Degraff, John Cook, Curtis C Harris, David Gius, James B Mitchell
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6377 (2009)
BACKGROUND:MicroRNAs (miRNAs) are small, highly conserved, non-coding RNA that alter protein expression and regulate multiple intracellular processes, including those involved in the response to cellular stress. Alterations in miRNA expression may oc
Externí odkaz:
https://doaj.org/article/9c1bacd4cad947c488e5e02b40d29a7f
Autor:
James B. Mitchell, Carter Van Waes, John A. Cook, Angela Thetford, Anastasia L. Sowers, Rajani Choudhuri, William DeGraff, Andrew J. Leiker
Supplementary Figure S4. The effects of PF-05212384 (10μM) on UMSCC46 radiation induced DNA damage repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08655e45d82a57b957b681b6c0b70a7b
https://doi.org/10.1158/1078-0432.22461104
https://doi.org/10.1158/1078-0432.22461104
Autor:
James B. Mitchell, Carter Van Waes, John A. Cook, Angela Thetford, Anastasia L. Sowers, Rajani Choudhuri, William DeGraff, Andrew J. Leiker
Purpose: Radiation remains a mainstay for the treatment of nonmetastatic head and neck squamous cell carcinoma (HNSCC), a malignancy characterized by a high rate of PI3K/mTOR signaling axis activation. We investigated the ATP-competitive dual PI3K/mT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c12d16ae5a0afde0689e83932db5ec0
https://doi.org/10.1158/1078-0432.c.6524696.v1
https://doi.org/10.1158/1078-0432.c.6524696.v1
Autor:
James B. Mitchell, Carter Van Waes, John A. Cook, Angela Thetford, Anastasia L. Sowers, Rajani Choudhuri, William DeGraff, Andrew J. Leiker
Supplementary Table S1. Senescence pathway directed RT-PCR genomic expression analysis of UMSCC1 cells treated with 24 hour PF-05212384 (10 �M) or DMSO (10 �M) followed by irradiation (10 Gy) or mock irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c03144d192d7aebd1e5cab05ef1295
https://doi.org/10.1158/1078-0432.22461092.v1
https://doi.org/10.1158/1078-0432.22461092.v1
Autor:
David A. Wink, Robert H. Wiltrout, Giorgio Trinchieri, James B. Mitchell, Howard A. Young, David D. Roberts, Aparna H. Kesarwala, Angela Thetford, Anastasia L. Sowers, William DeGraff, C. Andrew Stewart, Julie L. Heinecke, Debashree Basudhar, David R. Soto-Pantoja, Sukhbir Kaur, Jonathan M. Weiss, Robert Y.S. Cheng, Lisa A. Ridnour
Supplementary Table 1. Th1 vs. Th2 Cytokine Trend. Supplementary Table 2. Effect of L-NAME on Radiation-induced Cytokine Expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524788bc8eff323eab7b75740197301a
https://doi.org/10.1158/0008-5472.22406027.v1
https://doi.org/10.1158/0008-5472.22406027.v1
Autor:
Eric Y. Chuang, James B. Mitchell, C. Norman Coleman, Shuping Zhao, Hailing Yan, William DeGraff, Gadisetti V.R. Chandramouli, John A. Cook, Mong-Hsun Tsai
Studies were conducted to determine whether gene expression profiles following a single dose of radiation would yield equivalent profiles following fractionated radiation in different tumor cell lines. MCF7 (breast), DU145 (prostate), and SF539 (glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61e022921b6c56568f4444e14cc87ac3
https://doi.org/10.1158/0008-5472.c.6496859
https://doi.org/10.1158/0008-5472.c.6496859
Autor:
Eric Y. Chuang, James B. Mitchell, C. Norman Coleman, Shuping Zhao, Hailing Yan, William DeGraff, Gadisetti V.R. Chandramouli, John A. Cook, Mong-Hsun Tsai
Supplementary Figures 1-3 from Gene Expression Profiling of Breast, Prostate, and Glioma Cells following Single versus Fractionated Doses of Radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1b845a88f1f6df4e266da56a80ec46
https://doi.org/10.1158/0008-5472.22371590.v1
https://doi.org/10.1158/0008-5472.22371590.v1