Zobrazeno 1 - 10
of 71
pro vyhledávání: '"William D. Rees"'
Autor:
Panagiotis Filis, Natasha Walker, Linda Robertson, Emily Eaton-Turner, Lauma Ramona, Michelle Bellingham, Maria R. Amezaga, Zulin Zhang, Beatrice Mandon-Pepin, Neil P. Evans, Richard M. Sharpe, Corinne Cotinot, William D. Rees, Peter O'Shaughnessy, Paul A. Fowler
Publikováno v:
Environment International, Vol 124, Iss , Pp 98-108 (2019)
Background: The increased incidence of diseases, including metabolic syndrome and infertility, may be related to exposure to the mixture of chemicals, which are ubiquitous in the modern environment (environmental chemicals, ECs). Xeno-detoxification
Externí odkaz:
https://doaj.org/article/adc6986ef00a48638d8c496636f10498
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The intestinal epithelium is replenished every 3–4 days through an orderly process that maintains important secretory and absorptive functions while preserving a continuous mucosal barrier. Intestinal epithelial cells (IECs) derive from a stable po
Externí odkaz:
https://doaj.org/article/7bcc0a01c0954b40a4351fb9aff05ed6
Publikováno v:
Microorganisms, Vol 8, Iss 7, p 994 (2020)
Background: Mycobacterium avium subspecies paratuberculosis (MAP), a member of the mycobacteriaceae family, causes Johne’s disease in ruminants, which resembles Crohn’s disease (CD) in humans. MAP was proposed to be one of the causes of human CD,
Externí odkaz:
https://doaj.org/article/a25287010fd1482db30f3d9ba5a5f4a4
Publikováno v:
PPAR Research, Vol 2008 (2008)
Beyond the short-term effects on fertility, there is increasing evidence that obesity or the consumption of an inappropriate diet by the mother during pregnancy adversely affects the long-term health of her offspring. PPAR and RXR isotypes are widely
Externí odkaz:
https://doaj.org/article/7b9f730f0b9147c592b87a6759bace61
Autor:
Tirosh Shapira, I. Abrrey Monreal, Sébastien P. Dion, David W. Buchholz, Brian Imbiakha, Andrea D. Olmstead, Mason Jager, Antoine Désilets, Guang Gao, Mathias Martins, Thierry Vandal, Connor A. H. Thompson, Aaleigha Chin, William D. Rees, Theodore Steiner, Ivan Robert Nabi, Eric Marsault, Julie Sahler, Diego G. Diel, Gerlinde R. Van de Walle, Avery August, Gary R. Whittaker, Pierre-Luc Boudreault, Richard Leduc, Hector C. Aguilar, François Jean
Publikováno v:
Nature. 605:340-348
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced owing to emerging variants of concern1,2. Development of host-directed thera
Autor:
Dominic A. Boardman, May Q. Wong, William D. Rees, Dan Wu, Megan E. Himmel, Paul C. Orban, Jens Vent-Schmidt, Nicholas C. Zachos, Theodore S. Steiner, Megan K. Levings
Publikováno v:
Journal of Autoimmunity. 134:102961
Regulatory T cell (Treg) therapy is a promising strategy to treat inflammatory bowel disease (IBD). Data from animal models has shown that Tregs specific for intestinal antigens are more potent than polyclonal Tregs at inhibiting colitis. Flagellins,
Autor:
William D. Rees, Nikita Telkar, David T.S. Lin, May Q. Wong, Chad Poloni, Ayda Fathi, Michael Kobor, Nicholas C. Zachos, Theodore S. Steiner
Publikováno v:
Cell reports. 38(3)
Acute damage to the intestinal epithelium can be repaired via de-differentiation of mature intestinal epithelial cells (IECs) to a stem-like state, but there is a lack of knowledge on how intestinal stem cells function after chronic injury, such as i
Autor:
Harry J McArdle, Lorraine Gambling, Helen E. Hayes, Valerie Joan Stevens, Susan M. Hay, William D. Rees
Publikováno v:
Journal of Developmental Origins of Health and Disease. 11:264-272
Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids requir
Autor:
William D. Rees
Publikováno v:
The Proceedings of the Nutrition Society. 78(1)
Nutritional science has traditionally used the reductionist approach to understand the roles of individual nutrients in growth and development. The macronutrient dense but micronutrient poor diets consumed by many in the Western world may not result
Publikováno v:
Journal of developmental origins of health and disease. 9(2)
Mitochondrial dysfunction and resulting changes in adiposity have been observed in the offspring of animals fed a high fat (HF) diet. As iron is an important component of the mitochondria, we have studied the offspring of female rats fed complete (Co