Zobrazeno 1 - 10
of 14
pro vyhledávání: '"William D. Paquette"'
Autor:
Dadi Gao, Elisabetta Morini, Monica Salani, Aram J. Krauson, Anil Chekuri, Neeraj Sharma, Ashok Ragavendran, Serkan Erdin, Emily M. Logan, Wencheng Li, Amal Dakka, Jana Narasimhan, Xin Zhao, Nikolai Naryshkin, Christopher R. Trotta, Kerstin A. Effenberger, Matthew G. Woll, Vijayalakshmi Gabbeta, Gary Karp, Yong Yu, Graham Johnson, William D. Paquette, Garry R. Cutting, Michael E. Talkowski, Susan A. Slaugenhaupt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Drugs that modify RNA splicing are promising treatments for many genetic diseases. Here the authors show that deep learning strategies can predict drug targets, strongly supporting the use of in silico approaches to expand the therapeutic potential o
Externí odkaz:
https://doaj.org/article/a1488d5827774183bb159243db93b815
Autor:
Nikolai Naryshkin, Anil Kumar Chekuri, Amal Dakka, Monica Salani, Yong Yu, Graham Johnson, Serkan Erdin, Garry R. Cutting, Elisabetta Morini, Kerstin Effenberger, William D. Paquette, Susan A. Slaugenhaupt, Xin Zhao, Ashok Ragavendran, Vijayalakshmi Gabbeta, Wencheng Li, Neeraj Sharma, Jana Narasimhan, Emily M. Logan, Michael E. Talkowski, Gary Mitchell Karp, Aram J. Krauson, Christopher R. Trotta, Dadi Gao, Woll Matthew G
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing due to mutation lead to dysregulated protein expression and contribute to a substantial fraction of human disease. Several classes of splicing modulator compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c014f7710f052fb51aa8cfa99553225
https://doi.org/10.1038/s41467-021-23663-2
https://doi.org/10.1038/s41467-021-23663-2
Autor:
Graham Johnson, J. H. Lin, Jinhai Yang, Xinchao Chen, Steven L. Wagner, Nicholas J. Mayhew, R. Jason Herr, William C. Mobley, Kevin D. Rynearson, William D. Paquette, Keith D. Barnes, Rudolph E. Tanzi, Samuel A. Sakwa, Phuong Nguyen, Ronald N. Buckle
Publikováno v:
Bioorganic & medicinal chemistry, vol 28, iss 22
Bioorg Med Chem
Bioorg Med Chem
The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2a9db01bac416e5d7c90cd4e945c41
https://escholarship.org/uc/item/4ps6s92t
https://escholarship.org/uc/item/4ps6s92t
Autor:
Emily M. Logan, Dadi Gao, Graham Johnson, Elisabetta Morini, Serkan Erdin, Nikolai Naryshkin, Susan A. Slaugenhaupt, Kerstin Effenberger, Matt Woll, Amal Dakka, Michael E. Talkowski, Vijayalakshmi Gabbeta, Ashok Ragavendran, Wencheng Li, Monica Salani, Gary Mitchell Karp, Anil Kumar Chekuri, Aram J. Krauson, William D. Paquette, Yong Yu, Chris Trotta
Pre-mRNA splicing is a key control point in human gene expression. Disturbances in splicing due to mutation or aberrant splicing regulatory networks lead to dysregulated protein expression and contribute to a substantial fraction of human disease. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921ae3edfae1c7d1d9e1eba7991015cd
Autor:
Steven L. Wagner, Phuong Nguyen, R. Jason Herr, Nicholas J. Mayhew, Ronald N. Buckle, Rudolph E. Tanzi, Keith D. Barnes, William D. Paquette, Samuel A. Sakwa, Graham Johnson, Kevin D. Rynearson
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(16)
The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e4f11394504d5c922610329f498c27
https://pubmed.ncbi.nlm.nih.gov/27426299
https://pubmed.ncbi.nlm.nih.gov/27426299
Autor:
Adam J. Csakai, William D. Paquette, Hidenori Takahashi, Fatoumata Camara, Hong-Jun Wang, A. Samuel Vellekoop, Roman Wolfgang Fleck, John E. Mangette, Xuemei Chen, Gregory P. Roth, Ravi Krishnamoorthy
Publikováno v:
Tetrahedron Letters. 52:1292-1295
A three-step method was developed to convert N-1 unprotected 3-substituted indoles to 3-substituted 2-acylaminoindoles. Established indole chlorination chemistry was employed to generate stable 2-trifluoroacetylamino indoles, which were subsequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c65bb76622d61146da7aa2a77d39b2a
https://doi.org/10.1016/j.tetlet.2011.01.051
https://doi.org/10.1016/j.tetlet.2011.01.051
Autor:
John S. Lazo, Marni Brisson Tierno, Tong Ying Shun, Caleb Foster, Paul A. Johnston, William D. Paquette, Kay M. Brummond, Peter Wipf, Sunita Shinde
Publikováno v:
ASSAY and Drug Development Technologies. 7:250-265
The University of Pittsburgh Molecular Library Screening Center (Pittsburgh, PA) conducted a screen with the National Institutes of Health compound library for inhibitors of in vitro cell division cycle 25 protein (Cdc25) B activity during the pilot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8825c4308e4d7cdc0733f3bbaad17c
https://doi.org/10.1089/adt.2008.186
https://doi.org/10.1089/adt.2008.186
Autor:
Adam J. Csakai, Fatoumata Camara, Yi Wang, Hong-Jun Wang, William D. Paquette, John E. Mangette
Publikováno v:
Tetrahedron Letters. 52:541-543
Facile intramolecular N-arylation catalyzed by CuI/ l -proline has been developed to prepare 6,12b-diaza-dibenzo[a,h]azulen-7-ones and benzo[f]pyrrolo[1,2-a][1,4]diazepin-4-ones in good to excellent yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94a4e2b8ba9d18ff036ca82e8da96441
https://doi.org/10.1016/j.tetlet.2010.11.117
https://doi.org/10.1016/j.tetlet.2010.11.117
Autor:
John S. Lazo, William D. Paquette, Ahmet Bakan, Andreas Vogt, Paul A. Johnston, Peter Wipf, Kara M. George Rosenker, Elizabeth R. Sharlow
Publikováno v:
Bioorganicmedicinal chemistry. 23(12)
The cell division cycle 25B dual specificity phosphatase (Cdc25B) regulates the normal progression of the mammalian cell cycle by dephosphorylating and activating cyclin-dependent kinase (Cdk) complexes, particularly in response to DNA damage. Elevat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d844d9616f53b5e8103a52fd9e3145
https://pubmed.ncbi.nlm.nih.gov/25703307
https://pubmed.ncbi.nlm.nih.gov/25703307
Autor:
Fatoumata Camara, William D. Paquette, Hong-Jun Wang, John E. Mangette, Yi Wang, Adam J. Csakai
Publikováno v:
ChemInform. 42
The heterocycles are prepared in excellent yield via PyBOP-promoted reaction of o-halobenzylamines with carboxylic acids followed by intramolecular N-arylation of the amide products (I), (III) and (V).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d39dee6606791d49a7f8ef3f3f23feef
https://doi.org/10.1002/chin.201118148
https://doi.org/10.1002/chin.201118148