Zobrazeno 1 - 10
of 27
pro vyhledávání: '"William D. Mallender"'
Autor:
Zachary A. Gurard-Levin, Brian McMillan, Douglas A. Whittington, Brian Doyon, Michael D. Scholle, Jacques Ermolieff, Madhavi Bandi, Mu-Sen Liu, Alvaro Amor, William D. Mallender
Publikováno v:
SLAS Technology, Vol 29, Iss 5, Pp 100173- (2024)
Polymerase β (POLB), with dual functionality as a lyase and polymerase, plays a critical role in the base excision repair (BER) pathway to maintain genomic stability. POLB knockout and rescue studies in BRCA1/2-mutant cancer cell lines revealed that
Externí odkaz:
https://doaj.org/article/2814a1a1f9b140339aad8d4a13a4a653
Autor:
Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles
Publikováno v:
Journal of medicinal chemistry. 64(5)
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5159f216a3701336ba4dda4e3a9836
https://pubmed.ncbi.nlm.nih.gov/33631934
https://pubmed.ncbi.nlm.nih.gov/33631934
Autor:
Trish T. Hoang, Xiansi Zhao, Michael E. Bembenek, Keith V. Wood, Zhong Hua Yan, Xiaofeng Yang, Marie K. Schwinn, Ping Li, Jingya Ma, William D. Mallender
Publikováno v:
Analytical biochemistry. 555
Neddylation is a posttranslational modification that regulates protein stability, activity, and subcellular localization. Here, we describe a new tool for exploring the neddylation cycle of cullin1 (Cul1) directly in a cellular context. This assay ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e410e9342973466d7531cef83b9d0c2b
https://pubmed.ncbi.nlm.nih.gov/29733811
https://pubmed.ncbi.nlm.nih.gov/29733811
Autor:
Kara Hoar, Jiejin Chen, Sean J. Harrison, Jingya Ma, James M. Gavin, Neil F. Bence, Wei Chen, Ping Li, Michael Sintchak, Nancy J. Bump, Qing Xu, Lawrence R. Dick, William D. Mallender, Jesse J. Chen, Alexandra E. Gould, Frank Bruzzese, Yafang Lin
Publikováno v:
Journal of Biological Chemistry. 289:22648-22658
E1 enzymes activate ubiquitin or ubiquitin-like proteins (Ubl) via an adenylate intermediate and initiate the enzymatic cascade of Ubl conjugation to target proteins or lipids. Ubiquitin-fold modifier 1 (Ufm1) is activated by the E1 enzyme Uba5, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6849a9cf4d33b291a3a2b8282c7b575a
https://doi.org/10.1074/jbc.m114.573972
https://doi.org/10.1074/jbc.m114.573972
Autor:
Lawrence R. Dick, Hua Liao, Neil Rollins, Xiaofeng Yang, William D. Mallender, Qing Xu, James E. Brownell, James M. Gavin, Jingyang Chen, Alexandra E. Gould, Huay-Keng Loke, Jingya Ma, Trupti Lingaraj, Benjamin S. Amidon
Publikováno v:
Journal of Biological Chemistry. 287:15512-15522
Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubiquitin-like proteins (UBLs), ubiquitin and FAT10. In this study, biochemical and biophysical experiments were performed to understand the mechanisms of how Uba6 recogniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8390648a5c38612be09d427f5d03696
https://doi.org/10.1074/jbc.m111.336198
https://doi.org/10.1074/jbc.m111.336198
Autor:
Michael E. Bembenek, Ping Li, Jennifer Alley, Heidi Spurling, Thomas F. Parsons, William D. Mallender, Jacqueline C. Pulido, Cynthia Barrett
Publikováno v:
ASSAY and Drug Development Technologies. 4:661-669
Adenine phosphoribosyltransferase plays a role in purine salvage by catalyzing the direct conversion of adenine to adenosine monophosphate. The involvement of the purine salvage pathway in tumor proliferation and angiogenesis makes adenine phosphorib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fc5aac54ccf01e95f0be0741ef04c1
https://doi.org/10.1089/adt.2006.4.661
https://doi.org/10.1089/adt.2006.4.661
Autor:
Michael E. Bembenek, Ping Li, Saurabh Menon, William D. Mallender, Michael Kuranda, Thomas F. Parsons, Eneida Pardo, Lawrence R. Dick
Publikováno v:
High-Throughput Screening in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::124775ee42f35b4a337d25aa313e03d4
https://doi.org/10.1002/9783527609321.ch5
https://doi.org/10.1002/9783527609321.ch5
Autor:
Michael E. Bembenek, Lester Pullen, Eric Kuhn, Ping Li, William D. Mallender, Thomas F. Parsons
Publikováno v:
ASSAY and Drug Development Technologies. 3:533-541
NAD synthetase is responsible for the conversion of nicotinic acid adenine dinucleotide to nicotinamide adenine dinucleotide. This reaction provides a biosynthetic route of the coenzyme and, thus, a source of cellular reducing equivalents. Alteration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bd03d7a0735f347993cb7a1c0dd563
https://doi.org/10.1089/adt.2005.3.533
https://doi.org/10.1089/adt.2005.3.533
Autor:
Michael R. Nichols, Kumar Sambamurti, Debra Yager, Lisa M. Kopcho, Jovita Marcinkeviciene, Terrone L. Rosenberry, Luisa Onstead, Christopher B. Eckman, Robert A. Copeland, William D. Mallender
Publikováno v:
Molecular Pharmacology. 59:619-626
The beta-site amyloid precursor protein-cleaving enzyme (BACE) cleaves the amyloid precursor protein to produce the N terminus of the amyloid beta peptide, a major component of the plaques found in the brains of Alzheimer's disease patients. Sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075313cc13d2c3a3fe882c0b220d0352
https://doi.org/10.1124/mol.59.3.619
https://doi.org/10.1124/mol.59.3.619
Autor:
Catherine L. Silski, Elizabeth Eckman, Tivadar Szegletes, Pamela B. Davis, John R. Schreiber, William D. Mallender, Thomas W. Ferkol
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 21:246-252
In cystic fibrosis (CF), the intense host inflammatory response to chronic infection largely accounts for the progressive pulmonary disease, and ultimately death. Neutrophils are the prominent inflammatory cells in the lungs of patients with CF, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035687bc3ea847aee29b2abc85fe6953
https://doi.org/10.1165/ajrcmb.21.2.3687
https://doi.org/10.1165/ajrcmb.21.2.3687