Zobrazeno 1 - 10
of 19
pro vyhledávání: '"William D. Kingsbury"'
Autor:
William D. Kingsbury, Jeffrey C. Boehm
Publikováno v:
International Journal of Peptide and Protein Research. 27:659-665
The synthesis of peptides useful for the investigation of microbial peptide transport is reported. These peptides, L-alanyl-L-2-thiophenylglycine (Ala-alpha-TPG), L-alanyl-L-2-thiophenylglycyl-L-alanine (Ala-alpha-TPG-Ala) and L-alanyl-L-alanyl-L-2-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::106a2c0363f1f1e6650a9dcc63e1119c
https://doi.org/10.1111/j.1399-3011.1986.tb01062.x
https://doi.org/10.1111/j.1399-3011.1986.tb01062.x
Publikováno v:
Chemical Research in Toxicology. 11:1352-1360
Camptothecin (CPT) and 10 structural analogues were studied to characterize their effects on specific rearrangements of DNA structure mediated by human and calf thymus DNA topoisomerases I. A 30 base pair DNA duplex containing a single high-efficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e326f030f1086f4a23314a201c46a5fb
https://doi.org/10.1021/tx9801110
https://doi.org/10.1021/tx9801110
Autor:
K. K. C. Sham, Henry M. Sarau, Lenox D. Martin, Robert A. Daines, William D. Kingsbury, Chambers Pamela Anne, James J. Foley, Dulcie B. Schmidt, Don E. Griswold
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f93c1576c872795200bbe7150680cb20
https://doi.org/10.1002/chin.199703183
https://doi.org/10.1002/chin.199703183
Autor:
S. M. Hech, Francis L. McCabe, Jeffrey C. Boehm, M. J. Caranfa, K. G. Holden, Randall K. Johnson, William D. Kingsbury, G. Gallagher, Leo F. Faucette, D. R. Jakas, R. P. Hertzberg
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::becacefba76198d61f05fc55e0783e26
https://doi.org/10.1002/chin.199122254
https://doi.org/10.1002/chin.199122254
Autor:
J. J. Taggart, A. Breen, K. K. C. Sham, J. Chan, Nambi Aiyar, Robert A. Daines, J. Disa, William D. Kingsbury
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429233d73e6aec87bd1616611dd452e8
https://doi.org/10.1002/chin.199806243
https://doi.org/10.1002/chin.199806243
Publikováno v:
Biochemistry. 37(26)
The effects of eleven camptothecin derivatives on calf thymus topoisomerase I-mediated cleavage of synthetic DNA duplex have revealed that the A ring of camptothecin is very important for its biochemical activity. Depending on the type, number, and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a92dc43cc67758b33c398f226e909f1
https://pubmed.ncbi.nlm.nih.gov/9649322
https://pubmed.ncbi.nlm.nih.gov/9649322
Autor:
Shau-Ming Mong, R. Lee Webb, Randall K. Johnson, Karl F. Erhard, L. I. Kruse, Francis L. McCabe, Charles W. Debrosse, Peter B. Harrsch, Stephen T. Ross, William D. Kingsbury
Publikováno v:
European Journal of Medicinal Chemistry. 24:363-370
To provide the antineoplastic agent nocodazole, 1, with improved solubility and drug-transport properties, The (S)-alanyl-2-glycyl moiety was introduced as a benzimidazole-nitrogen-substituent which would be expected to be enzymatically cleaved in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eec12bff369402109560805313e49bf
https://doi.org/10.1016/0223-5234(89)90079-2
https://doi.org/10.1016/0223-5234(89)90079-2
Autor:
William D. Kingsbury
Publikováno v:
Tetrahedron Letters. 29:6847-6850
Reaction of camptothecin ( 1 ) in DMF solution with sodium azide led to the formation of mappicine ketone ( 3 ). Sodium borohydride reduction of 3 gave the racemic natural product mappicine ( 4 ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a991c09ac0dc32769bc2364e65f7eab5
https://doi.org/10.1016/s0040-4039(00)88456-7
https://doi.org/10.1016/s0040-4039(00)88456-7
Publikováno v:
Journal of Medicinal Chemistry. 26:1725-1729
A series of di- and tripeptides containing D- and L-m-fluorophenylalanine was prepared and tested in vitro for the ability to inhibit the growth of the yeast Candida albicans. The results demonstrate that peptides containing L-m-fluorophenylalanine i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1669c21547b67dcd6d05d356c1d3229a
https://doi.org/10.1021/jm00366a013
https://doi.org/10.1021/jm00366a013
Autor:
Jeffrey L. McDermott, Teru Hideshima, Ruben D. Carrasco, Mikael Altun, Kenneth C. Anderson, Joseph Weinstock, Craig A. Leach, Nikhil C. Munshi, Paul G. Richardson, Matthew P. Kodrasov, Benedikt M. Kessler, Stephane Minvielle, Dharminder Chauhan, Parantu K. Shah, Benjamin Nicholson, William D. Kingsbury, K. G. Suresh Kumar, Mariaterresa Fulcinniti, Bin Zhou, Ze Tian, Robert Z. Orlowski
Publikováno v:
Cancer Cell. (3):345-358
SummaryBortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed, and newly diagnosed multiple myeloma (MM); however, dose-limiting toxicities and the development of resistance limit its long-term utility. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d62a74b329dab3144ae5e88c9f00f9