Zobrazeno 1 - 10
of 62
pro vyhledávání: '"William D. Hazelton"'
Autor:
E. Georg Luebeck, Kit Curtius, William D. Hazelton, Sean Maden, Ming Yu, Prashanthi N. Thota, Deepa T. Patil, Amitabh Chak, Joseph E. Willis, William M. Grady
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-10 (2017)
Abstract Background Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences, and dynamics of epi
Externí odkaz:
https://doaj.org/article/98577dabbc1e4e40b76e727b3863035f
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008961 (2021)
Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal expansion (MSCE) model for cancer can be harnessed to identify biological processes that shap
Externí odkaz:
https://doaj.org/article/933bcd9832fc4c53bfa8ba5520dd0f72
Autor:
William M. Grady, John M. Inadomi, Yanxin Luo, Andrew M. Kaz, Maria Westerhoff, Polly A. Newcomb, Cornelia M. Ulrich, Christopher I. Li, Paul D. Lampe, Wynn Burke, Kelly T. Carter, Ming Yu, Sean K. Maden, Kit Curtius, William D. Hazelton, Georg E. Luebeck
This file provides a list of drift-related CGI-gene pairs for which methylation is significantly correlated with gene expression (q-value ) in left colon (including rectum) and right colon.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5289f92cf5546594bcfb2716dc9f86
https://doi.org/10.1158/0008-5472.22422023.v1
https://doi.org/10.1158/0008-5472.22422023.v1
Autor:
E. Georg Luebeck, Chin Hur, John M. Inadomi, Eric J. Feuer, Marjolein van Ballegooijen, Iris Lansdorp-Vogelaar, Sung Eun Choi, Melecia C. Miller, Curtis R. Heberle, Rafael Meza, Jihyoun Jeon, William D. Hazelton, Kit Curtius, Sonja Kroep, Chung Yin Kong
PDF - 1235K, Referred to as "Appendix". Supplementary Materials and Methods. Figure A1. Schematic diagram of MSEAC Model. Figure A2. Cell Proliferation Rates by Birth Cohort, Males. Figure A3. Cell Proliferation Rates by Birth Cohort, Females. Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9e733dc85a8dbeaa7238092f25294c
https://doi.org/10.1158/1055-9965.22437597.v1
https://doi.org/10.1158/1055-9965.22437597.v1
Cancer screening and early detection efforts have been partially successful in reducing incidence and mortality, but many improvements are needed. Although current medical practice is informed by epidemiologic studies and experts, the decisions for g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e730b102dc8efcc18d40cd7d8c99b0
https://doi.org/10.1158/0008-5472.c.6512467
https://doi.org/10.1158/0008-5472.c.6512467
Autor:
E. Georg Luebeck, Chin Hur, Joel H. Rubenstein, Rafael Meza, Thomas L. Vaughan, John M. Inadomi, Kit Curtius, William D. Hazelton
Background: U.S. esophageal adenocarcinoma (EAC) incidence increased over 5-fold between 1975 and 2009. Symptomatic gastroesophageal reflux disease (sGERD) elevates the risk for EAC. However, a simple calculation suggests that changes in sGERD preval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b5ce27f164943083487bc95649e5fa
https://doi.org/10.1158/1055-9965.c.6515260.v1
https://doi.org/10.1158/1055-9965.c.6515260.v1
Autor:
William M. Grady, John M. Inadomi, Yanxin Luo, Andrew M. Kaz, Maria Westerhoff, Polly A. Newcomb, Cornelia M. Ulrich, Christopher I. Li, Paul D. Lampe, Wynn Burke, Kelly T. Carter, Ming Yu, Sean K. Maden, Kit Curtius, William D. Hazelton, Georg E. Luebeck
Many normal tissues undergo age-related drift in DNA methylation, providing a quantitative measure of tissue age. Here, we identify and validate 781 CpG islands (CGI) that undergo significant methylomic drift in 232 normal colorectal tissues and show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe81d072d3b4d98214b6bb6be3dc85d
https://doi.org/10.1158/0008-5472.c.6511112.v1
https://doi.org/10.1158/0008-5472.c.6511112.v1
Autor:
E. Georg Luebeck, Chin Hur, John M. Inadomi, Eric J. Feuer, Marjolein van Ballegooijen, Iris Lansdorp-Vogelaar, Sung Eun Choi, Melecia C. Miller, Curtis R. Heberle, Rafael Meza, Jihyoun Jeon, William D. Hazelton, Kit Curtius, Sonja Kroep, Chung Yin Kong
Background: The incidence of esophageal adenocarcinoma (EAC) has increased five-fold in the United States since 1975. The aim of our study was to estimate future U.S. EAC incidence and mortality and to shed light on the potential drivers in the disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457e0e06c5ecd8115475f2c4044b9c06
https://doi.org/10.1158/1055-9965.c.6515961
https://doi.org/10.1158/1055-9965.c.6515961
Autor:
E. Georg Luebeck, Chin Hur, Joel H. Rubenstein, Rafael Meza, Thomas L. Vaughan, John M. Inadomi, Kit Curtius, William D. Hazelton
Figure S1. EAC model including GERD and OF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189d936b5b3169b139856884b8a35e6d
https://doi.org/10.1158/1055-9965.22436161.v1
https://doi.org/10.1158/1055-9965.22436161.v1
Autor:
William M. Grady, John M. Inadomi, Yanxin Luo, Andrew M. Kaz, Maria Westerhoff, Polly A. Newcomb, Cornelia M. Ulrich, Christopher I. Li, Paul D. Lampe, Wynn Burke, Kelly T. Carter, Ming Yu, Sean K. Maden, Kit Curtius, William D. Hazelton, Georg E. Luebeck
Derivation of adenoma to carcinoma sojourn times, with table S1 showing estimated methylation drift rate parameters and table S2 showing estimated sojourn times for three tissue age models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387086829e2f16edc62f32ab39e210d5
https://doi.org/10.1158/0008-5472.22422017.v1
https://doi.org/10.1158/0008-5472.22422017.v1