Zobrazeno 1 - 10
of 21
pro vyhledávání: '"William D. Hastings"'
Autor:
Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Simon Liang, Jiyoung Elizabeth Choi, Minying Pu, Dongshu Chen, Tyler Laszewski, Stephanie Schwartz, Jane Gu, Leandra Mansur, Tyler Burks, Lauren Brodeur, Roberto Velazquez, Steve Kovats, Bhavesh Pant, Giri Buruzula, Emily Deng, Julie T. Chen, Farid Sari-Sarraf, Christina Dornelas, Malini Varadarajan, Haiyan Yu, Chen Liu, Joanne Lim, Huai-Xiang Hao, Xiaomo Jiang, Anthony Malamas, Matthew J. LaMarche, Felipe Correa Geyer, Margaret McLaughlin, Carlotta Costa, Joel Wagner, David Ruddy, Pushpa Jayaraman, Nathaniel D. Kirkpatrick, Pu Zhang, Oleg Iartchouk, Kimberly Aardalen, Viviana Cremasco, Glenn Dranoff, Jeffrey A. Engelman, Serena Silver, Hongyun Wang, William D. Hastings, Silvia Goldoni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted a
Externí odkaz:
https://doaj.org/article/aeca1d5b6b344aeabcc21b726ae4f617
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
CSF1R-driven SHP2-dependent MAPK signaling in GDM-1 cells and SHP2 dependency of the viability in M-CSF-stimulated monocytes in the T cell co-culture assay, and the in vivo combination benefit in suppressing tumor associated macrophage by anti-PD-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06731a1fc427831477507d6aebca12e0
https://doi.org/10.1158/1078-0432.22478133
https://doi.org/10.1158/1078-0432.22478133
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4250d56edcf37820adc098681f1006
https://doi.org/10.1158/1078-0432.22478130
https://doi.org/10.1158/1078-0432.22478130
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
The synergy in the MAPK pathway suppression and anti-proliferation effect by KRASG12C inhibitor and TNO155.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013172c44043cee447214f4abb7b9e85
https://doi.org/10.1158/1078-0432.22478136.v1
https://doi.org/10.1158/1078-0432.22478136.v1
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
Identification of the feedback activated RTK and the synergy in anti-proliferation effect by the combination of respective RTK inhibitors and dabrafenib plus trametinib in RKO and MDST8 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7cb8da75cd0e34edbe53dd9cde73d8
https://doi.org/10.1158/1078-0432.22478139
https://doi.org/10.1158/1078-0432.22478139
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
Purpose:SHP2 inhibitors offer an appealing and novel approach to inhibit receptor tyrosine kinase (RTK) signaling, which is the oncogenic driver in many tumors or is frequently feedback activated in response to targeted therapies including RTK inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23801ceeb7ba68ce8b8d9fedfdac102e
https://doi.org/10.1158/1078-0432.c.6529860
https://doi.org/10.1158/1078-0432.c.6529860
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
The activity of nazartinib, TNO155, and their combination in EGFR mutant NSCLC cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e76c9d37ca76d9da6ce735c084db98
https://doi.org/10.1158/1078-0432.22478127.v1
https://doi.org/10.1158/1078-0432.22478127.v1
Autor:
Juliet Williams, Jeffrey A. Engelman, Guizhi Yang, Matthew J. Meyer, Huai Xiang Hao, William D. Hastings, Chen Liu, Tinya Abrams, Silvia Goldoni, Hui Gao, Giordano Caponigro, Peter S. Hammerman, Hongyun Wang, Colleen Kowal, Scott Delach, Alice Loo, Hengyu Lu, Susan Moody, Matthew J. LaMarche, Ye Wang, Karrie Wong, Morvarid Mohseni, Xiamei Zhang
Publikováno v:
Clinical Cancer Research. 27:342-354
Purpose: SHP2 inhibitors offer an appealing and novel approach to inhibit receptor tyrosine kinase (RTK) signaling, which is the oncogenic driver in many tumors or is frequently feedback activated in response to targeted therapies including RTK inhib
Autor:
Jonathan R. Greene, Elena Ivanova, Moataz Noureddine, Luke J. Taus, David Liu, Tyler Teceno, Maria Pinzon-Ortiz, Navin R. Mahadevan, Tran C. Thai, Derek Liu, Andrew Portell, Amir Vajdi, Shunsuke Kitajima, Prafulla C. Gokhale, Paul Kirschmeier, Juan J. Miret, David A. Barbie, Patrick H. Lizotte, Russell W. Jenkins, Cloud P. Paweletz, Kartik Sehgal, Peter S. Hammerman, Christie J. Lau, Carino Gurjao, William D. Hastings, Tetsuo Tani, Silvia Goldoni, Marios Giannakis
Publikováno v:
J Clin Invest
Resistance to oncogene-targeted therapies involves discrete drug-tolerant persister cells, originally discovered through in vitro assays. Whether a similar phenomenon limits efficacy of programmed cell death 1 (PD-1) blockade is poorly understood. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0b912b1501dd2137016a8614b61480
https://europepmc.org/articles/PMC7810472/
https://europepmc.org/articles/PMC7810472/
Autor:
David Liu, Tyler Teceno, Shunsuke Kitajima, Tran C. Thai, Kartik Sehgal, Carino Gurjao, Moataz Noureddine, Cloud P. Paweletz, Navin R. Mahadevan, William D. Hastings, Prafulla C. Gokhale, Tetsuo Tani, Silvia Goldoni, Andrew Portell, Derek Liu, Peter S. Hammerman, Christie J. Lau, Patrick H. Lizotte, Marios Giannakis, Jonathan R. Greene, Maria Pinzon-Ortiz, Elena Ivanova, Paul Kirschmeier, Juan J. Miret, Russell W. Jenkins, Amir Vadji, David A. Barbie, Luke J. Taus
Publikováno v:
Regular and young investigator award abstracts.
Background To understand fundamental mechanisms of immune escape, we leveraged our functional ex vivo platform of murine derived organotypic tumor spheroids (DOTS)1 to determine if drug-tolerant persister cells analogous to oncogene targeted therapie