Zobrazeno 1 - 10
of 24
pro vyhledávání: '"William D. Gwynne"'
Autor:
Jeremy K. Chan, William D. Gwynne, Brandon Y. Lieng, Andrew T. Quaile, Chitra Venugopal, Sheila K. Singh, J. Rafael Montenegro-Burke
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102736- (2023)
Summary: Liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and lipidomics have recently been used to show that MYC-amplified group 3 medulloblastoma tumors are driven by metabolic reprogramming. Here, we present a protocol to extract
Externí odkaz:
https://doaj.org/article/55d757e604f842cdb3471f89c9648dbf
Autor:
David Bakhshinyan, Yujin Suk, Laura Kuhlmann, Ashley A. Adile, Vladimir Ignatchenko, Stefan Custers, William D. Gwynne, Andrew Macklin, Chitra Venugopal, Thomas Kislinger, Sheila K. Singh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Medulloblastoma (MB) is the most common type of malignant pediatric brain cancer. The current standard of care (SOC) involves maximal safe resection and chemoradiotherapy in individuals older than 3 years, often leading to devastating neuroc
Externí odkaz:
https://doaj.org/article/4d03f9f8846c4b28a993fd246a4af2b1
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound
Externí odkaz:
https://doaj.org/article/3eace71e4f774decb598d79c690ed3aa
Autor:
David Bakhshinyan, Yujin Suk, Laura Kuhlmann, Ashley A. Adile, Vladimir Ignatchenko, Stefan Custers, William D. Gwynne, Andrew Macklin, Chitra Venugopal, Thomas Kislinger, Sheila K. Singh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a8f03f8fe12c41f0a4d7d6925b44dd42
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a3f8e3d5b4894e4aa4350454d71f0f4e
Autor:
Ian Burns, William D. Gwynne, Yujin Suk, Stefan Custers, Iqra Chaudhry, Chitra Venugopal, Sheila K. Singh
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Pediatric central nervous system (CNS) tumors are the most common solid tumors diagnosed in children and are the leading cause of pediatric cancer-related death. Those who do survive are faced with the long-term adverse effects of the current standar
Externí odkaz:
https://doaj.org/article/0df59904668147fb90dd55e95fe625dd
Autor:
William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar, John A. Hassell
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-17 (2020)
Abstract Background Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scarcity in tumors. We pr
Externí odkaz:
https://doaj.org/article/8582578dace944f6837d54e4a3840059
Autor:
William D. Gwynne, Mirza S. Shakeel, Jianhan Wu, Robin M. Hallett, Adele Girgis-Gabardo, Anna Dvorkin-Gheva, John A. Hassell
Publikováno v:
Cellular & Molecular Biology Letters, Vol 24, Iss 1, Pp 1-13 (2019)
Abstract Background Breast tumor growth and recurrence are driven by an infrequent population of breast tumor-initiating cells (BTIC). We and others have reported that the frequency of BTIC is orders of magnitude higher when breast tumor cells are pr
Externí odkaz:
https://doaj.org/article/00b38dd4e70b45fc949157a9595cd2a2
Publikováno v:
Molecules, Vol 26, Iss 11, p 3171 (2021)
Breast tumors were the first tumors of epithelial origin shown to follow the cancer stem cell model. The model proposes that cancer stem cells are uniquely endowed with tumorigenic capacity and that their aberrant differentiation yields non-tumorigen
Externí odkaz:
https://doaj.org/article/fdc6618ea65445fd8b1b9d803e1e020e
Autor:
William D. Gwynne, Yujin Suk, Stefan Custers, Nicholas Mikolajewicz, Jeremy K. Chan, Zsolt Zador, Shawn C. Chafe, Kui Zhai, Laura Escudero, Cunjie Zhang, Olga Zaslaver, Chirayu Chokshi, Muhammad Vaseem Shaikh, David Bakhshinyan, Ian Burns, Iqra Chaudhry, Omri Nachmani, Daniel Mobilio, William T. Maich, Patricia Mero, Kevin R. Brown, Andrew T. Quaile, Chitra Venugopal, Jason Moffat, J. Rafael Montenegro-Burke, Sheila K. Singh
Publikováno v:
Cancer cell. 40(12)
MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic screening and metabolomic profiling to identify multiple cancer-selectiv