Zobrazeno 1 - 10
of 24
pro vyhledávání: '"William D. G. Brittain"'
Autor:
Shan Wang, William D. G. Brittain, Qian Zhang, Zhou Lu, Ming Him Tong, Kewen Wu, Kwaku Kyeremeh, Matthew Jenner, Yi Yu, Steven L. Cobb, Hai Deng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Non-Ribosomal Peptide Synthetases (NRPSs) are responsible for the construction of many types of natural products. Here the authors characterize a key type II thioesterase domain that sheds light on the chain translocation processes of legonmycin NRPS
Externí odkaz:
https://doaj.org/article/a8612ce1af86463f93d09e6be79f839a
Autor:
Thomas G. F. Marsh, Alessia Santambrogio, Ben J. Murray, Lee T. Boulton, Juan A. Aguilar, Dmitry S. Yufit, Graham Sandford, William D. G. Brittain
Publikováno v:
European Journal of Organic Chemistry, 2023, Vol.26(11), pp.e202300058 [Peer Reviewed Journal]
Trifluoromethyl ynones derived from the refrigerant gas HFO-1234yf (2,3,3,3-tetrafluoropropene) react with nucleophiles via a Michael-type addition process and the allenolate intermediate formed reacts intramolecularly with a carbonyl group to form h
Autor:
Yiming Zhao, Fernanda Meloni, Louise Male, Cécile S. Le Duff, William D. G. Brittain, Benjamin R. Buckley, John S. Fossey
Publikováno v:
Organic Chemistry Frontiers.
The synthesis of atropisomeric phosphino-triazoles through a CuAAC approach is disclosed. Gold(i) chloride complexes of single-enantiomer phosphines were then prepared and again demonstrated to be conformationally stable.
Publikováno v:
Organic & Biomolecular Chemistry, 2022, Vol.20(41), pp.8059-8064 [Peer Reviewed Journal]
Acyl fluorides are valuable synthetic intermediates, but in some cases they can be challenging to handle and difficult to isolate given their susceptibility to degradation. In addition, many reagents utilised to prepare acyl fluorides are incompatibl
Publikováno v:
Chemistry – A European Journal. 28
Autor:
Steven L. Cobb, William D. G. Brittain
Publikováno v:
Journal of organic chemistry, 2020, Vol.85(11), pp.6862-6871 [Peer Reviewed Journal]
Being able to utilise a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalisation of complex organic molecules. However, protecting groups that have the ability to influence reaction
Autor:
Zhenquan Sun, Andrew G. Dalling, Cécile S. Le Duff, Benjamin R. Buckley, Louise Male, John S. Fossey, William D. G. Brittain
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
A non-enzymatic simultaneous (coined coetaneous) kinetic resolution of a racemic alkyne and racemic azide, utilising an asymmetric CuAAC reaction is reported. The use of a CuCl (R,R)-Ph-Pybox catalyst system effects a simultaneous kinetic resolution
Autor:
Cécile S. Le Duff, Benjamin R. Buckley, John S. Fossey, Louise Male, Fernanda Meloni, Andrew G. Leach, William D. G. Brittain
The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or 1,2,3-triazole C-5-aryl bonds were investigated by ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8888b3811369f80ea772cbd6e110b3b6
https://doi.org/10.33774/chemrxiv-2021-znd87
https://doi.org/10.33774/chemrxiv-2021-znd87
Publikováno v:
Brittain, W D G & Coxon, C R 2021, ' Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation ', Chemistry-A European Journal . https://doi.org/10.1002/chem.202103305
Chemistry : a European journal, 2022, Vol.28(7), pp.10-23 [Peer Reviewed Journal]
Chemistry : a European journal, 2022, Vol.28(7), pp.10-23 [Peer Reviewed Journal]
Perfluoroaromatic and perfluoroheteroaromatic reagents have emerged in recent years as powerful reagents for peptide and protein modification. Dominated by their regio- and chemoselective nucleophilic aromatic substitution chemistry under mild condit
Autor:
William D. G. Brittain, Steven L. Cobb
Publikováno v:
Organic Letters, 2021, Vol.23(15) [Peer Reviewed Journal]
Organic Letters
Organic Letters
This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl fluorides can be formed from a range of acids under mild conditions. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce35fbe55d914df80f412779613d4b63
http://dro.dur.ac.uk/34633/
http://dro.dur.ac.uk/34633/