Zobrazeno 1 - 10
of 45
pro vyhledávání: '"William D. Darwin"'
Autor:
Robert S. Goodwin, David A. Gorelick, Eugene W. Schwilke, Marilyn A. Huestis, William D. Darwin, David M. Schwope, Deanna L. Kelly, Garry Milman
Publikováno v:
Clinical Chemistry. 57:1597-1606
BACKGROUND Oral fluid (OF) testing is increasingly important for drug treatment, workplace, and drugged-driving programs. There is interest in predicting plasma or whole-blood concentrations from OF concentrations; however, the relationship between t
Autor:
Harrison G. Pope, Marilyn A. Huestis, William D. Darwin, David A. Gorelick, C. Nora Chiang, Jean Lud Cadet, Eugene W. Schwilke, Rod G. Gullberg
Publikováno v:
Addiction. 106:499-506
Aims To develop and validate empirically a mathematical model for identifying new cannabis use in chronic, daily cannabis smokers. Design Models were based on urinary creatinine‐normalized (CN) cannabinoid excretion in chronic cannabis smokers. Set
Autor:
Marilyn A. Huestis, William D. Darwin, Garry Milman, David A. Gorelick, Deanna L. Kelly, Allan J. Barnes, David M. Schwope, Eugene W. Schwilke, Robert S. Goodwin
Publikováno v:
Clinical Chemistry. 56:1261-1269
BACKGROUND Oral fluid, a promising alternative matrix for drug monitoring in clinical and forensic investigations, offers noninvasive sample collection under direct observation. Cannabinoid distribution into oral fluid is complex and incompletely cha
Autor:
Erin L. Karschner, Eugene W. Schwilke, Robert S. Goodwin, David M. Schwope, William D. Darwin, David A. Gorelick, Marilyn A. Huestis, Ross H. Lowe, Deanna L. Kelly
Publikováno v:
Clinical Chemistry. 55:2180-2189
Background: Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. No plasma pharmacokinetic data after repeated oral THC administration are available. Methods: Six adul
Autor:
Tsadik T. Abraham, William D. Darwin, Ronald I. Herning, Marilyn A. Huestis, Jean Lud Cadet, Ross H. Lowe
Publikováno v:
Drug and Alcohol Dependence. 105:24-32
Background Generally, urinary 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) after alkaline hydrolysis is monitored to detect cannabis exposure, although last use may have been weeks prior in chronic cannabis users. Δ9-Tetrahydrocannabinol (THC
Autor:
Marilyn A. Huestis, Elin Lehrmann, William D. Darwin, Amy Deep-Soboslay, Mary M. Herman, Thomas M. Hyde, William J. Freed, Zoan R. Afanador, Jean Lud Cadet, Ross H. Lowe, Allan J. Barnes, Gloria Gallegos, Joel E. Kleinman
Publikováno v:
Addiction Biology. 13:105-117
The present study examines the diagnostic challenges of identifying ante-mortem illicit substance use in human postmortem cases. Substance use, assessed by clinical case history reviews, structured next-of-kin interviews, by general toxicology of blo
Publikováno v:
Journal of Analytical Toxicology. 31:477-485
A sensitive and specific method for extraction and quantification of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THCCOOH) in human urine was developed
Autor:
Marilyn A. Huestis, Eric T. Moolchan, Judith A. Kuhnle, Catherine K. Okano, Timothy P. Lyons, William D. Darwin, Mark R. Bruins
Publikováno v:
Journal of Analytical Toxicology. 25:559-564
In this study, we investigated the effectiveness of the Roche Kinetic Interaction of Microparticles in Solution (KIMS) screening assay for cannabinoid metabolites. Urine specimens (N = 1689) were collected during elimination of cannabinoids from 25 s
Autor:
Buddha D. Paul, J Summers, Edward J. Cone, D Nichols, Michael L. Smith, Eric T. Shimomura, R Shippee, William D. Darwin, Amanda J. Jenkins
Publikováno v:
Journal of Analytical Toxicology. 24:522-529
The Federal Workplace Drug Testing Program changed urine screening and confirmation cutoff concentrations for opiate testing from 300 to 2000 ng/mL in 1998. Morphine was the designated target compound. An additional heroin metabolite, 6-acetylmorphin
Publikováno v:
Therapeutic Drug Monitoring. 20:556-560
Cocaine abusers frequently self-administer cocaine by different routes of administration. A controlled-dosing study was performed to assess the effect of different routes of administration on the excretion profile of cocaine and metabolites in urine.