Zobrazeno 1 - 10
of 121
pro vyhledávání: '"William D. Bloomer"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6039-6048
Twenty three 3-nitrotriazole- and five nitroimidazole-based compounds, mostly amides, were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv (Mtb H37Rv) under aerobic or low oxygen conditions, intracellular activity in mur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917ac43333235c819dbd12286662da54
https://doi.org/10.1016/j.bmc.2017.09.037
https://doi.org/10.1016/j.bmc.2017.09.037
Publikováno v:
European Journal of Medicinal Chemistry. 138:1106-1113
A limited number of novel 3-nitrotriazole- and 2-nitroimidazole-linked quinolines and quinazolines were synthesized and screened for in vitro antitrypanosomal and antitubercular activities as well as cytotoxicity in normal cells. All compounds were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7358990f9d9727d51c116393c0df688
https://doi.org/10.1016/j.ejmech.2017.07.060
https://doi.org/10.1016/j.ejmech.2017.07.060
Autor:
Shane R. Wilkinson, William D. Bloomer, Marcel Kaiser, Maria V. Papadopoulou, Howard S. Rosenzweig, Joanna Szular
Publikováno v:
European Journal of Medicinal Chemistry
A small series of 5-nitro-2-aminothiazole-based amides containing arylpiperazine-, biphenyl- or aryloxyphenyl groups in their core were synthesized and evaluated as antitrypanosomatid agents. All tested compounds were active or moderately active agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b00932745986569b98ac2aece062dda
Autor:
Marcel Kaiser, Ivan P. O'Shea, Maria V. Papadopoulou, William D. Bloomer, Jean-Robert Ioset, Shane R. Wilkinson, Eric Chatelain, Howard S. Rosenzweig
Publikováno v:
Bioorganic & Medicinal Chemistry. 23(19):6467-6476
3-Nitro-1H-1,2,4-triazole- and 2-nitro-1H-imidazole-based amides with an aryloxy-phenyl core were synthesized and evaluated as antitrypanosomal agents. All 3-nitrotriazole-based derivatives were extremely potent anti-Trypanosoma cruzi agents at sub n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740a0580eb0a34be1147a2a13371b0ed
Autor:
William D. Bloomer, Howard S. Rosenzweig, Maria V. Papadopoulou, Marcel Kaiser, Shane R. Wilkinson, Ivan P. O'Shea
Publikováno v:
European Journal of Medicinal Chemistry. 103:325-334
Novel linear 3-nitro-1H-1,2,4-triazole-based piperazides were synthesized and evaluated as antitrypanosomal agents. In addition, some bisarylpiperazine-ethanones which were formed as by-products were also screened for antiparasitic activity. Most 3-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22caf79ccafd34ce47912abc1f8fdbb0
Autor:
Vathsala T. Raghavan, Hussain Habib, Arif Shaikh, William D. Bloomer, Shalin Shah, Megan Tobias, Alexandra Kyrillos, Kristine Kuchta, Katharine Yao, Catherine Pesce
Publikováno v:
Annals of surgical oncology. 24(10)
Accelerated partial breast irradiation (APBI) was developed to address disadvantages of overall treatment time and potentially unnecessary radiation associated with whole breast irradiation (WBI). We report updated results of our single institution s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a9898a9fb4629bd5d5bc4051380f16
https://pubmed.ncbi.nlm.nih.gov/28766205
https://pubmed.ncbi.nlm.nih.gov/28766205
Autor:
Howard S. Rosenzweig, Marcel Kaiser, William D. Bloomer, Maria V. Papadopoulou, Eric Chatelain, Jean-Robert Ioset
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6600-6607
We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. In the present work we further expanded our researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a81cefc800a5d6d906e26263fa96a8
https://doi.org/10.1016/j.bmc.2013.08.022
https://doi.org/10.1016/j.bmc.2013.08.022
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 108:396-399
Bioreductive drugs can cause retinal toxicity, mediated by extensive apoptosis in the outer retina of rodents and monkeys. In the present study, we have investigated whether or not the novel and promising hypoxia-selective cytotoxin 4-[3-(2-nitro-1-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e308ca680c09fdbe45bd71f066b6337f
https://doi.org/10.1111/j.1742-7843.2010.00667.x
https://doi.org/10.1111/j.1742-7843.2010.00667.x
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 106:511-522
4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a 2-nitroimidazole-based hypoxia-selective cytotoxin has been shown to target hypoxic regions of solid tumours. The present study is one of several pre-clinical toxico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c3d8365a8000cdcf88027295d4fa15
https://doi.org/10.1111/j.1742-7843.2009.00532.x
https://doi.org/10.1111/j.1742-7843.2009.00532.x
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 106:497-504
In pre-clinical studies, 4-[3-(2-nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1, NSC 709257) is a weak DNA-intercalating, hypoxia-selective cytotoxin with a promising profile as an adjuvant to radio/chemotherapy and it is ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f873205e3dfa3d439f7c04645c4a5bf6
https://doi.org/10.1111/j.1742-7843.2009.00530.x
https://doi.org/10.1111/j.1742-7843.2009.00530.x