Zobrazeno 1 - 10
of 37
pro vyhledávání: '"William D Shrader"'
Autor:
Amanda H Kahn-Kirby, Akiko Amagata, Celine I Maeder, Janet J Mei, Steve Sideris, Yuko Kosaka, Andrew Hinman, Stephanie A Malone, Joel J Bruegger, Leslie Wang, Virna Kim, William D Shrader, Kevin G Hoff, Joey C Latham, Euan A Ashley, Matthew T Wheeler, Enrico Bertini, Rosalba Carrozzo, Diego Martinelli, Carlo Dionisi-Vici, Kimberly A Chapman, Gregory M Enns, William Gahl, Lynne Wolfe, Russell P Saneto, Simon C Johnson, Jeffrey K Trimmer, Matthew B Klein, Charles R Holst
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214250 (2019)
BACKGROUND:Mitochondrial disease is a family of genetic disorders characterized by defects in the generation and regulation of energy. Epilepsy is a common symptom of mitochondrial disease, and in the vast majority of cases, refractory to commonly us
Externí odkaz:
https://doaj.org/article/8d6a4743a7c54e47b90913a261c70803
Autor:
Andrew Hinman, Charles R Holst, Joey C Latham, Joel J Bruegger, Gözde Ulas, Kevin P McCusker, Akiko Amagata, Dana Davis, Kevin G Hoff, Amanda H Kahn-Kirby, Virna Kim, Yuko Kosaka, Edgar Lee, Stephanie A Malone, Janet J Mei, Steve James Richards, Veronica Rivera, Guy Miller, Jeffrey K Trimmer, William D Shrader
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201369 (2018)
Ferroptosis is a form of programmed cell death associated with inflammation, neurodegeneration, and ischemia. Vitamin E (alpha-tocopherol) has been reported to prevent ferroptosis, but the mechanism by which this occurs is controversial. To elucidate
Externí odkaz:
https://doaj.org/article/1875891c4736481eb71993aa2c674781
Autor:
Edgar Lee, Akiko Amagata, Yuko Kosaka, William D. Shrader, Jeffrey K. Trimmer, Joey C. Latham, Stephanie Malone, Joel J. Bruegger, Andrew W. Hinman, Janet J. Mei, Guy M. Miller, Kevin P. McCusker, Veronica Rivera, Gözde Ulas, Charles R. Holst, Steve James Richards, Dana A. Davis, Amanda H. Kahn-Kirby, Kevin G. Hoff, Virna Kim
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201369 (2018)
PLoS ONE
PLoS ONE
Ferroptosis is a form of programmed cell death associated with inflammation, neurodegeneration, and ischemia. Vitamin E (alpha-tocopherol) has been reported to prevent ferroptosis, but the mechanism by which this occurs is controversial. To elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6b022573bc2a35a0f1340b150fee5f
http://europepmc.org/articles/PMC6093661?pdf=render
http://europepmc.org/articles/PMC6093661?pdf=render
Autor:
Guy M. Miller, Fiorella Piemonte, Andrew W. Hinman, Susanna Livadiotti, Martin Thoolen, Anna Pastore, Michela Catteruccia, Matthew B. Klein, Carlo Dionisi-Vici, Diego Martinelli, Enrico Bertini, Viktoria Kheifets, Giulia Tozzi, William D. Shrader, Giuseppe Pontrelli, Tiziana Corsetti
Publikováno v:
Molecular Genetics and Metabolism. 107:383-388
article i nfo Background: Genetically defined Leigh syndrome is a rare, fatal inherited neurodegenerative disorder that predominantly affects children. No treatment is available. EPI-743 is a novel small molecule developed for the treatment of Leigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9074dd95bd9708116bac0345db1f83a7
https://doi.org/10.1016/j.ymgme.2012.09.007
https://doi.org/10.1016/j.ymgme.2012.09.007
Autor:
William D. Shrader, Steven M. Willi, Amale Hawi, M. Grazia Cotticelli, Eric Deutsch, Karlla W. Brigatti, Patrice Rioux, Olena Kucheruk, Guy M. Miller, Thomas Sciascia, David A. Lynch, Robert B. Wilson
Publikováno v:
Movement Disorders. 27:1026-1033
This study tested the ability of A0001 (α-tocopheryl quinone; EPI-A0001), a potent antioxidant, to improve in vitro measures, glucose metabolism, and neurological function in Friedreich ataxia. We used an in vitro study of protection from cell toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f4fe4d22f3e05c6f38a16474727fe7b
https://doi.org/10.1002/mds.25058
https://doi.org/10.1002/mds.25058
Autor:
Aleksandr Kolesnikov, Ellen Sanford, Dange Vijaykumar, Michael J. Green, Kieron E. Wesson, Jennifer R. Riggs, Paul A. Sprengeler, Troy A. Wahl, Christine Yu, William D. Shrader, Huiyong Hu, Ellen M. Leahy, Wendy B. Young, Zhiwei Tong, Brad A. Katz, Margaret Nguyen, Ronnel Cabuslay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3197-3200
The discovery and development of 5-azaindole factor VIIa inhibitors will be described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6dfbca8762f93301eb848f0e0542d0
https://doi.org/10.1016/j.bmcl.2006.03.049
https://doi.org/10.1016/j.bmcl.2006.03.049
Autor:
Michael J. Green, Juthamas Sukbuntherng, John Hendrix, Liang Liu, William D. Shrader, Jennifer R. Riggs, Robin Stephens, Wendy B. Young, Aleksandr Kolesnikov, Dange Vijaykumar, Lin Pan, Joyce Mordenti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2224-2228
We have developed a series of potent and selective factor VIIa inhibitors based on the 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6-hydroxy-biphenyl-3-yl]-succinic acid scaffold. These amidine-containing compounds have low oral bioavailability. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4831838897a3cccd13c882578d23a2f9
https://doi.org/10.1016/j.bmcl.2006.01.039
https://doi.org/10.1016/j.bmcl.2006.01.039
Autor:
Ellen Sanford, Roopa Rai, Steven M. Torkelson, William D. Shrader, Ronnell Cabuslay, Bradley A. Katz, Paul A. Sprengeler, Tony Ton, Aleksandr Kolesnikov, Robin Stephens, Wendy B. Young, Christine Yu, John Hendrix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2270-2273
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c66e188d0e81cf4dc4e2d539122d536
https://doi.org/10.1016/j.bmcl.2006.01.017
https://doi.org/10.1016/j.bmcl.2006.01.017
Autor:
Roopa Rai, Kyle Elrod, William D. Shrader, James W. Janc, Yong Li, Lynne Cregar, Wendy B. Young, Aleksandr Kolesnikov, Thomas E. Jenkins, Paul R. Fatheree, Brad A. Katz, Erik Verner, Paul A. Sprengeler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:710-713
Inhibition of coagulation proteases such as thrombin, fXa, and fVIIa has been a focus of ongoing research to produce safe and effective antithrombotic agents. Herein, we describe a unique zinc-mediated chelation strategy to streamline the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890f430c3bb6f05e6bfb08f3695a2bf1
https://doi.org/10.1016/j.bmcl.2005.10.023
https://doi.org/10.1016/j.bmcl.2005.10.023
Autor:
William D. Shrader, Wendy B. Young, Christine Yu, Jie Tang, Paul A. Sprengeler, Douglas A. Jeffery, Jeff Spencer, Steven R. Williams, Alberto Estevez, Bradley A. Katz, Eric B. Springman, Mary E. McGrath, Jun Sampang
Publikováno v:
Journal of Biological Chemistry. 280:41077-41089
Plasma kallikrein is a serine protease that has many important functions, including modulation of blood pressure, complement activation, and mediation and maintenance of inflammatory responses. Although plasma kallikrein has been purified for 40 year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5e9403e67908e1441faf4c35cfb7b0
https://doi.org/10.1074/jbc.m506766200
https://doi.org/10.1074/jbc.m506766200