Zobrazeno 1 - 10
of 26
pro vyhledávání: '"William D Lees"'
Autor:
Lenka Stejskal, Mphatso D Kalemera, Charlotte B Lewis, Machaela Palor, Lucas Walker, Tina Daviter, William D Lees, David S Moss, Myrto Kremyda-Vlachou, Zisis Kozlakidis, Giulia Gallo, Dalan Bailey, William Rosenberg, Christopher JR Illingworth, Adrian J Shepherd, Joe Grove
Publikováno v:
eLife, Vol 11 (2022)
E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2 is a putative intrinsic
Externí odkaz:
https://doaj.org/article/37ff4043bb984f729123cad9b74a85a6
Autor:
Lenka Stejskal, William D Lees, David S Moss, Machaela Palor, Richard J Bingham, Adrian J Shepherd, Joe Grove
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007710 (2020)
The glycoproteins of hepatitis C virus, E1E2, are unlike any other viral fusion machinery yet described, and are the current focus of immunogen design in HCV vaccine development; thus, making E1E2 both scientifically and medically important. We used
Externí odkaz:
https://doaj.org/article/a608e8700b86497797ac584c2be653fa
Autor:
Andrew M. Collins, Mats Ohlin, Martin Corcoran, James M. Heather, Duncan Ralph, Mansun Law, Jesus Martínez-Barnetche, Jian Ye, Eve Richardson, William S. Gibson, Oscar L. Rodriguez, Ayelet Peres, Gur Yaari, Corey T. Watson, William D. Lees
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more
Externí odkaz:
https://doaj.org/article/aa654cd36aa94db1a0e3b47ed8578d9f
Autor:
Mats Ohlin, Cathrine Scheepers, Martin Corcoran, William D. Lees, Christian E. Busse, Davide Bagnara, Linnea Thörnqvist, Jean-Philippe Bürckert, Katherine J. L. Jackson, Duncan Ralph, Chaim A. Schramm, Nishanth Marthandan, Felix Breden, Jamie Scott, Frederick A. Matsen IV, Victor Greiff, Gur Yaari, Steven H. Kleinstein, Scott Christley, Jacob S. Sherkow, Sofia Kossida, Marie-Paule Lefranc, Menno C. van Zelm, Corey T. Watson, Andrew M. Collins
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity. Recently, high-throughp
Externí odkaz:
https://doaj.org/article/ff5064523d2c4931a175eb46313164cf
Autor:
Ayelet Peres, William D. Lees, Oscar L. Rodriguez, Noah Y. Lee, Pazit Polak, Ronen Hope, Meirav Kedmi, Andrew M. Collins, Mats Ohlin, Steven H. Kleinstein, Corey T Watson, Gur Yaari
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is a crucial step. This process is highly impacted by allele annotations. Aligning sequences, assigning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f48ab09732df7e614d75bacdf548eb
https://doi.org/10.1101/2022.12.26.521922
https://doi.org/10.1101/2022.12.26.521922
Autor:
William D. Lees, Scott Christley, Ayelet Peres, Justin T. Kos, Brian Corrie, Duncan Ralph, Felix Breden, Lindsay G. Cowell, Gur Yaari, Martin Corcoran, Gunilla B. Karlsson Hedestam, Mats Ohlin, Andrew M. Collins, Corey T. Watson, Christian E. Busse
Publikováno v:
ImmunoInformatics. 10:100025
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d40b3eb3fada45253a0ff6bf16cafc5d
https://doi.org/10.1016/j.immuno.2023.100025
https://doi.org/10.1016/j.immuno.2023.100025
Autor:
David S. Moss, Myrto Kremyda-Vlachou, Lucas Walker, Machaela Palor, Tina Daviter, Joe Grove, William Rosenberg, William D. Lees, Christopher J. R. Illingworth, Lenka Stejskal, Zisis Kozlakidis, Mphatso D Kalemera, Adrian J. Shepherd
E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2 is a putative intrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20afc277b41633eb8ec061248be458dc
Autor:
Mphatso D Kalemera, Lenka Stejskal, Charlotte B Lewis, Machaela Palor, Lucas Walker, Tina Daviter, William D Lees, David S Moss, Myrto Kremyda-Vlachou, Zisis Kozlakidis, Giulia Gallo, Dalan Bailey, William Rosenberg, Christopher JR Illingworth, Adrian J Shepherd, Joe Grove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d6cdc883bdfc67d88a1811f944a520
https://doi.org/10.7554/elife.71854.sa2
https://doi.org/10.7554/elife.71854.sa2
Autor:
William D. Lees
Publikováno v:
Current Opinion in Systems Biology. 24:86-92
Tools for adaptive immune receptor repertoire (AIRR) sequencing continue to evolve rapidly, and, although some established frameworks are emerging, there are no complete solutions: it is necessary to select tools and build a customised pipeline. Emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d294a3ac9b1dca7b12a7cdcec6d2e09
https://doi.org/10.1016/j.coisb.2020.10.003
https://doi.org/10.1016/j.coisb.2020.10.003
Autor:
Justin T. Kos, Yana Safonova, Kaitlyn M. Shields, Catherine A. Silver, William D. Lees, Andrew M. Collins, Corey T. Watson
The light chain immunoglobulin genes of biomedically relevant mouse strains are poorly documented in current germline gene databases. We previously showed that IGH loci of wild-derived mouse strains representing the major mouse subspecies contained 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4dff5be1ca8fccf024b0c10dd9e4f9c
https://doi.org/10.1101/2022.05.01.489089
https://doi.org/10.1101/2022.05.01.489089