Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William D, Thompson"'
Autor:
Samuel E. Jones, Jacqueline M. Lane, Andrew R. Wood, Vincent T. van Hees, Jessica Tyrrell, Robin N. Beaumont, Aaron R. Jeffries, Hassan S. Dashti, Melvyn Hillsdon, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar, Seth A. Sharp, Yingjie Jie, William D. Thompson, Jamie W. Harrison, Amy Dawes, Enda M. Byrne, Henning Tiemeier, Karla V. Allebrandt, Jack Bowden, David W. Ray, Rachel M. Freathy, Anna Murray, Diego R. Mazzotti, Philip R. Gehrman, Debbie A. Lawlor, Timothy M. Frayling, Martin K. Rutter, David A. Hinds, Richa Saxena, Michael N. Weedon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
GWAS have previously found 24 genomic loci associated with chronotype, an individual’s preference for early or late sleep timing. Here, the authors identify 327 additional loci in a sample of 697,828 individuals and further explore the relationship
Externí odkaz:
https://doaj.org/article/7d76303f46514c92adc6ac6228d3ae3f
Autor:
William D Thompson, Jessica Tyrrell, Maria-Carolina Borges, Robin N Beaumont, Bridget A Knight, Andrew R Wood, Susan M Ring, Andrew T Hattersley, Rachel M Freathy, Debbie A Lawlor
Publikováno v:
PLoS Medicine, Vol 16, Iss 6, p e1002828 (2019)
BackgroundSystematic reviews of randomised controlled trials (RCTs) have suggested that maternal vitamin D (25[OH]D) and calcium supplementation increase birth weight. However, limitations of many trials were highlighted in the reviews. Our aim was t
Externí odkaz:
https://doaj.org/article/bdf6673a81dd40a3ac26519e7ac355fe
Publikováno v:
Cognitive Science. 47
Autor:
William D Thompson, Robin N Beaumont, Alan Kuang, Nicole M Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R Wood, Denise M Scholtens, Bridget A Knight, David M Evans, William L Lowe Jr, Gillian Santorelli, Raq Azad, Dan Mason, Andrew T Hattersley, Timothy M Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A Lawlor, Rachel M Freathy
Publikováno v:
Human Molecular Genetics. 31:1762-1775
Background Higher birthweight is associated with higher adult body mass index (BMI). Alleles that predispose to greater adult adiposity might act in fetal life to increase fetal growth and birthweight. Whether there are fetal effects of recently iden
Autor:
William D. Thompson, Rafaq Azad, Jessica Tyrrell, Timothy M. Frayling, Dan Mason, Yingjie Ji, Gillian Santorelli, Bridget A. Knight, Robin N Beaumont, Debbie A Lawlor, Maria Carolina Borges, Alan Kuang, Rachel M. Freathy, David M. Evans, Nicole M. Warrington, Hanieh Yaghootkar, Andrew T. Hattersley, Denise M. Scholtens, Andrew R. Wood, William L. Lowe
Publikováno v:
Thompson, W D, Beaumont, R N, Kuang, A, Warrington, N M, Jie, Y, Tyrrell, J, Wood, A R, Scholtens, D M, Knight, B A, Evans, D M, L Lowe Jr, W, Santorelli, G, Azad, R, Mason, D, Hattersley, A T, Frayling, T M, Yaghootkar, H, Borges, M C, Lawlor, D A & Freathy, R M 2021, ' Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile ', Diabetologia, vol. 64, no. 12, pp. 2790-2802 . https://doi.org/10.1007/s00125-021-05570-9
Diabetologia
Diabetologia
Data availability: Our study uses two-sample MR. We used both published summary results (i.e. taking results from published research papers and websites) and individual participant cohort data: journal-published and website summary data were used for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b94d793255748accd9dc44d7d3a4c4
https://research-information.bris.ac.uk/en/publications/5d0be5a3-564e-46e4-b123-f3581703e55d
https://research-information.bris.ac.uk/en/publications/5d0be5a3-564e-46e4-b123-f3581703e55d
Autor:
Nicole M. Warrington, Andrew T. Hattersley, Dan Mason, Alan Kuang, William D. Thompson, Rafaq Azad, David M. Evans, Debbie A Lawlor, Jessica Tyrrell, Andrew R. Wood, Hanieh Yaghootkar, Yingjie Ji, Timothy M. Frayling, Rachel M. Freathy, Denise M. Scholtens, Beatrice Knight, Maria Carolina Borges, William L. Lowe, Gillian Santorelli, Robin N Beaumont
Aims/HypothesisHigher maternal BMI during pregnancy results in higher offspring birth weight, but it is not known whether this is solely the result of adverse metabolic consequences of higher maternal adiposity, such as maternal insulin resistance an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab1af3651177011ef3f2fe4764ef031
https://doi.org/10.1101/2020.05.25.20112441
https://doi.org/10.1101/2020.05.25.20112441
Autor:
Bridget A. Knight, Robin N Beaumont, William D. Thompson, Rachel M. Freathy, Andrew R. Wood, Andrew T. Hattersley, Susan M. Ring, Jessica Tyrrell, Maria Carolina Borges, Debbie A Lawlor
Publikováno v:
PLoS Medicine, Vol 16, Iss 6, p e1002828 (2019)
Thompson, W D, Tyrrell, J, Borges, C, Beaumont, R N, Knight, B A, Wood, A R, Ring, S, Hattersley, A T, Freathy, R & Lawlor, D 2019, ' Association of maternal circulating 25(OH)D and calcium with birth weight : A mendelian randomisation analysis ', PLoS Medicine, vol. 16, no. 6, e1002828, pp. e1002828 . https://doi.org/10.1371/journal.pmed.1002828
PLOS Medicine
PLoS Medicine
Thompson, W D, Tyrrell, J, Borges, C, Beaumont, R N, Knight, B A, Wood, A R, Ring, S, Hattersley, A T, Freathy, R & Lawlor, D 2019, ' Association of maternal circulating 25(OH)D and calcium with birth weight : A mendelian randomisation analysis ', PLoS Medicine, vol. 16, no. 6, e1002828, pp. e1002828 . https://doi.org/10.1371/journal.pmed.1002828
PLOS Medicine
PLoS Medicine
Background Systematic reviews of randomised controlled trials (RCTs) have suggested that maternal vitamin D (25[OH]D) and calcium supplementation increase birth weight. However, limitations of many trials were highlighted in the reviews. Our aim was
Autor:
Jessica, Tyrrell, Anwar, Mulugeta, Andrew R, Wood, Ang, Zhou, Robin N, Beaumont, Marcus A, Tuke, Samuel E, Jones, Katherine S, Ruth, Hanieh, Yaghootkar, Seth, Sharp, William D, Thompson, Yingjie, Ji, Jamie, Harrison, Rachel M, Freathy, Anna, Murray, Michael N, Weedon, Cathryn, Lewis, Timothy M, Frayling, Elina, Hyppönen
Publikováno v:
International Journal of Epidemiology
Background Depression is more common in obese than non-obese individuals, especially in women, but the causal relationship between obesity and depression is complex and uncertain. Previous studies have used genetic variants associated with BMI to pro
Autor:
Jonathan M. Locke, William D. Thompson, Jess Tyrrell, Rachel M. Freathy, West B, Beaumont Rn, James W. Harrison, Niels Grarup, C M Lindgren, Anna Murray, Francesco Casanova, Andrew R. Wood, Ruth Ks, Seth A. Sharp, Timothy M. Frayling, Yingjie Ji, Marcus A. Tuke, Samuel E. Jones, Michael N. Weedon, Hanieh Yaghootkar
SummaryFibroblast Growth Factor 21 (FGF21) is a hormone that induces weight loss in model organisms. These findings have led to trials in humans of FGF21 analogues with some showing weight loss and lipid lowering effects. Recent genetic studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2f852524791d5ec99f582e2f8df2e6
https://doi.org/10.1101/214700
https://doi.org/10.1101/214700
Autor:
William D, Thompson
Publikováno v:
Caring : National Association for Home Care magazine. 23(4)