Zobrazeno 1 - 10
of 122
pro vyhledávání: '"William D, Martin"'
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 205-212 (2024)
ABSTRACTIntroduction Clinical trials of personalized cancer vaccines have shown that on-demand therapies that are manufactured for each patient, result in activated T cell responses against individual tumor neoantigens. However, their use has been tr
Externí odkaz:
https://doaj.org/article/c49a5329643540508e3c44e5426a9e1f
Autor:
Brian J. Roberts, Aimee E. Mattei, Kristina E. Howard, James L. Weaver, Hao Liu, Sandra Lelias, William D. Martin, Daniela Verthelyi, Eric Pang, Katie J. Edwards, Anne S. De Groot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Advances in synthetic peptide synthesis have enabled rapid and cost-effective peptide drug manufacturing. For this reason, peptide drugs that were first produced using recombinant DNA (rDNA) technology are now being produced using solid- and liquid-p
Externí odkaz:
https://doaj.org/article/674dd4b85a844bff9f2eb55deb7c7e13
Autor:
Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTIn silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is ‘fully human’, T cell epitopes that are
Externí odkaz:
https://doaj.org/article/d3ac97f35912434aae9b77e2b10534c0
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Biologics developers are moving beyond antibodies for delivery of a wide range of therapeutic interventions. These non-antibody modalities are often based on ‘natural’ protein scaffolds that are modified to deliver bioactive sequences. Both human
Externí odkaz:
https://doaj.org/article/fb0855ea9b154b43a5269a481f59c86f
Autor:
Christopher S. Eickhoff, Krystal A. Meza, Frances E. Terry, Chase G. Colbert, Azra Blazevic, Andres H. Gutiérrez, E. Taylor Stone, James D. Brien, Amelia K. Pinto, Hana M. El Sahly, Mark J. Mulligan, Nadine Rouphael, Maria L. Alcaide, Kay M. Tomashek, Chris Focht, William D. Martin, Leonard Moise, Anne S. De Groot, Daniel F. Hoft
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Zika virus (ZIKV) is a flavivirus primarily transmitted by Aedes species mosquitoes, first discovered in Africa in 1947, that disseminated through Southeast Asia and the Pacific Islands in the 2000s. The first ZIKV infections in the Americas were ide
Externí odkaz:
https://doaj.org/article/ab83e318f0cb4dbabe18cdf845f5b0cf
Autor:
Dennis L. Foss, Andres H. Gutiérrez, Meggan Bandrick, Sudeep Perumbakkam, Anne S. De Groot, William D. Martin, Frances E. Terry, Alvaro Aldaz, James R.D. Allison, Jose Angulo
Publikováno v:
Veterinary Vaccine, Vol 2, Iss 2, Pp 100028- (2023)
Porcine circovirus type 2 (PCV2) is a globally important pathogen of swine with a high capacity for genetic change, potentially including evolution of strains less susceptible to vaccine induced immunity. Starting with DNA sequences, in silico tools
Externí odkaz:
https://doaj.org/article/c071ccc514dd4c91afffd779f78ca323
Autor:
Guilhem Richard, Anne S. De Groot, Gary D. Steinberg, Tzintzuni I. Garcia, Alec Kacew, Matthew Ardito, William D. Martin, Gad Berdugo, Michael F. Princiotta, Arjun V. Balar, Randy F. Sweis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Improvement of risk stratification through prognostic biomarkers may enhance the personalization of cancer patient monitoring and treatment. We used Ancer, an immunoinformatic CD8, CD4, and regulatory T cell neoepitope screening system, to p
Externí odkaz:
https://doaj.org/article/d371f9d2ea90470a84bf2e9f0ded5167
Autor:
Sundos Khan, Matthew Parrillo, Andres H. Gutierrez, Frances E. Terry, Leonard Moise, William D. Martin, Anne S. De Groot
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 2, Pp 214-227 (2020)
The RTS,S/AS01 malaria vaccine will undergo a pilot vaccination study in sub-Saharan Africa beginning in 2019. RTS,S/AS01 Phase III trials reported an efficacy of 28.3% (children 5–17 months) and 18.3% (infants 6–12 weeks), with substantial varia
Externí odkaz:
https://doaj.org/article/b25679b1043d468187d7b251086ecf24
Autor:
Corine Kruiswijk, Guilhem Richard, Merijn L.M. Salverda, Pooja Hindocha, William D. Martin, Anne S. De Groot, Elly Van Riet
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 2, Pp 277-285 (2020)
The resurgence of whooping cough since the introduction of acellular (protein) vaccines has led to a renewed interest in the development of improved pertussis vaccines; Outer Membrane Vesicles (OMVs) carrying pertussis antigens have emerged as viable
Externí odkaz:
https://doaj.org/article/e9d3b6f1744f446c8936748d61200a94
Autor:
Vinayaka Kotraiah, Timothy W. Phares, Frances E. Terry, Pooja Hindocha, Sarah E. Silk, Carolyn M. Nielsen, Leonard Moise, Kenneth D. Tucker, Rebecca Ashfield, William D. Martin, Anne S. De Groot, Simon J. Draper, Gabriel M. Gutierrez, Amy R. Noe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The hurdles to effective blood stage malaria vaccine design include immune evasion tactics used by the parasite such as redundant invasion pathways and antigen variation among circulating parasite strains. While blood stage malaria vaccine developmen
Externí odkaz:
https://doaj.org/article/2deefbdc3cd44a348943f7cc2e674f49