Zafirlukast Is a Promising Scaffold for Selectively Inhibiting TNFR1 Signaling

Autor: Nagamani Vunnam, Mu Yang, Chih Hung Lo, Carolyn Paulson, William D. Fiers, Evan Huber, MaryJane Been, David M. Ferguson, Jonathan N. Sachs

Publikováno v: ACS Bio & Med Chem Au.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::755fe7c99107f5db3d51536314426ce2
https://doi.org/10.1021/acsbiomedchemau.2c00048

Immune regulation by fungal strain diversity in inflammatory bowel disease

Autor: Xin V. Li, Irina Leonardi, Gregory G. Putzel, Alexa Semon, William D. Fiers, Takato Kusakabe, Woan-Yu Lin, Iris H. Gao, Itai Doron, Alejandra Gutierrez-Guerrero, Meghan B. DeCelie, Guilhermina M. Carriche, Marissa Mesko, Chen Yang, Julian R. Naglik, Bernhard Hube, Ellen J. Scherl, Iliyan D. Iliev

Publikováno v: Li, X V, Leonardi, I, Putzel, G G, Semon, A, Fiers, W D, Kusakabe, T, Lin, W-Y, Gao, I H, Doron, I, Gutierrez-Guerrero, A, DeCelie, M B, Mesko, M, Chen, Y, Naglik, J R, Hube, B, Scherl, E J & Iliev, I D 2022, ' Immune regulation by fungal strain diversity in inflammatory bowel disease ', NATURE, vol. 603, no. 7902, pp. 672-678 . https://doi.org/10.1038/s41586-022-04502-w
Nature

The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation1,2,3,4,5,6. Although aberrant changes in the mycobiot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e70399a7894d340f4b7da93db72b2df
https://kclpure.kcl.ac.uk/en/publications/b6cc3903-a678-4ec5-b9df-57dcaa1eda45

Gut mycobiota under scrutiny: fungal symbionts or environmental transients?

Autor: Iris H. Gao, William D. Fiers, Iliyan D. Iliev

Publikováno v: Curr Opin Microbiol

The human gastrointestinal tract is home to a thriving community of microbes including the fungal ‘mycobiota’. Although sequencing methodology has enumerated diverse fungal genera within this niche, discerning persistent symbiotic residents from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025810370c9558452af020cde3d64206
https://doi.org/10.1016/j.mib.2019.09.010

Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease

Autor: Itai, Doron, Marissa, Mesko, Xin V, Li, Takato, Kusakabe, Irina, Leonardi, Dustin G, Shaw, William D, Fiers, Woan-Yu, Lin, Meghan, Bialt-DeCelie, Elvira, Román, Randy S, Longman, Jesus, Pla, Patrick C, Wilson, Iliyan D, Iliev

Publikováno v: Nature microbiology. 6(12)

Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by shaping the resident microbiota community, restricting the growth of bacterial pathogens and enhancing host protective immunity via immunological exclusion. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2d454e16f25bb223ef8af7b64a7e072
https://pubmed.ncbi.nlm.nih.gov/34811532

Structural Basis of Polyketide Synthase O-Methylation

Autor: Peter Wipf, Steffen M. Bernard, Marissa M. Bivins, Sarang Kulkarni, David H. Sherman, Meredith A. Skiba, Janet L. Smith, John R. Schultz, William D. Fiers, Qingyun Dan, Courtney C. Aldrich, William H. Gerwick

Publikováno v: ACS chemical biology, vol 13, iss 12

Modular type I polyketide synthases (PKSs) produce some of the most chemically complex metabolites in nature through a series of multienzyme modules. Each module contains a variety of catalytic domains to selectively tailor the growing molecule. PKS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3587cf5749e1f6c63c102647d9c9c31c
https://europepmc.org/articles/PMC6470024/