Zobrazeno 1 - 3
of 3
pro vyhledávání: '"William D, Capel"'
Autor:
Robert J. Lefkowitz, William D. Capel, Michael J. Robertson, Georgios Skiniotis, Alissa L. W. Kleinhenz, Dean P. Staus, Naomi R. Latorraca, Laura M. Wingler, Hongli Hu
Publikováno v:
Nature
After activation by an agonist, G-protein-coupled receptors (GPCRs) recruit β-arrestin, which desensitizes heterotrimeric G-protein signalling and promotes receptor endocytosis1. Additionally, β-arrestin directly regulates many cell signalling path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efd599fe56055577c922d7be1c08c5
https://doi.org/10.1038/s41586-020-1954-0
https://doi.org/10.1038/s41586-020-1954-0
Autor:
Minjung, Choi, Dean P, Staus, Laura M, Wingler, Seungkirl, Ahn, Biswaranjan, Pani, William D, Capel, Robert J, Lefkowitz
Publikováno v:
Science signaling. 11(544)
Biased agonists of G protein-coupled receptors (GPCRs), which selectively activate either G protein- or β-arrestin-mediated signaling pathways, are of major therapeutic interest because they have the potential to show improved efficacy and specifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ca239fe510d57d528f2f3f14932b171
https://pubmed.ncbi.nlm.nih.gov/30131371
https://pubmed.ncbi.nlm.nih.gov/30131371
G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β 2 -adrenergic receptor
Autor:
Robert J. Lefkowitz, Laura M. Wingler, Dean P. Staus, Biswaranjan Pani, Minjung Choi, William D. Capel, Seungkirl Ahn
Publikováno v:
Science Signaling. 11
Biased agonists of G protein-coupled receptors (GPCRs), which selectively activate either G protein- or β-arrestin-mediated signaling pathways, are of major therapeutic interest because they have the potential to show improved efficacy and specifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecea4d8966a1fa535ecb1a46f5ab81c
https://doi.org/10.1126/scisignal.aar7084
https://doi.org/10.1126/scisignal.aar7084