Zobrazeno 1 - 10
of 117
pro vyhledávání: '"William Conway"'
Autor:
Robert Kiewisz, Gunar Fabig, William Conway, Daniel Baum, Daniel Needleman, Thomas Müller-Reichert
Publikováno v:
eLife, Vol 11 (2022)
During cell division, kinetochore microtubules (KMTs) provide a physical linkage between the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into bundles, so-called kinetochore-fibers (k-fibers), but the ultrastructure
Externí odkaz:
https://doaj.org/article/91c889fd98c347b5a706552efa28bb7d
Autor:
William Conway, Robert Kiewisz, Gunar Fabig, Colm P Kelleher, Hai-Yin Wu, Maya Anjur-Dietrich, Thomas Müller-Reichert, Daniel J Needleman
Publikováno v:
eLife, Vol 11 (2022)
During eukaryotic cell division, chromosomes are linked to microtubules (MTs) in the spindle by a macromolecular complex called the kinetochore. The bound kinetochore microtubules (KMTs) are crucial to ensuring accurate chromosome segregation. Recent
Externí odkaz:
https://doaj.org/article/20af85c9d44a467fa6ea5249a367b0c4
Autor:
Agnieszka K. Witkiewicz, Uthra Balaji, Cody Eslinger, Elizabeth McMillan, William Conway, Bruce Posner, Gordon B. Mills, Eileen M. O’Reilly, Erik S. Knudsen
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 2017-2031 (2016)
Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance. Here, we use exome sequencing of patient tumors and find multiple conserved genetic
Externí odkaz:
https://doaj.org/article/a48c60604edc4d72a656d77e93f20118
Publikováno v:
eLife, Vol 7 (2018)
Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions. Here, we present a m
Externí odkaz:
https://doaj.org/article/d5999231277943729ba818bea259caa0
Autor:
Won-Ki Cho, Namrata Jayanth, Brian P English, Takuma Inoue, J Owen Andrews, William Conway, Jonathan B Grimm, Jan-Hendrik Spille, Luke D Lavis, Timothée Lionnet, Ibrahim I Cisse
Publikováno v:
eLife, Vol 5 (2016)
Protein clustering is a hallmark of genome regulation in mammalian cells. However, the dynamic molecular processes involved make it difficult to correlate clustering with functional consequences in vivo. We developed a live-cell super-resolution appr
Externí odkaz:
https://doaj.org/article/492d9368f0144434aab5205106f266e9
Autor:
Fátima Valdés-Mora, Robert Salomon, Brian Stewart Gloss, Andrew Man Kit Law, Jeron Venhuizen, Lesley Castillo, Kendelle Joan Murphy, Astrid Magenau, Michael Papanicolaou, Laura Rodriguez de la Fuente, Daniel Lee Roden, Yolanda Colino-Sanguino, Zoya Kikhtyak, Nona Farbehi, James Ronald William Conway, Neblina Sikta, Samantha Richelle Oakes, Thomas Robert Cox, Seán Ignatius O’Donoghue, Paul Timpson, Christopher John Ormandy, David Gallego-Ortega
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108945- (2021)
Summary: Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate the cellular basis of tumor progression during the specificat
Externí odkaz:
https://doaj.org/article/ea3e8ab5138c4f7d98816a22a8d74a0d
Autor:
Yanjie Xu, Qi Yang, Graeme Puxty, Hai Yu, William Conway, Mengxiang Fang, Tao Wang, Roger J. Mulder
Publikováno v:
Industrial & Engineering Chemistry Research. 61:12493-12503
Autor:
William Conway
Patagonia. The name connotes the exotic and a distance that seems nearly mythical. Tucked toward the toe of South America, this largely unsettled landscape is among the most varied and breathtaking in the world-aching in its beauty as it sweeps from
Autor:
Denny Sakkas, Daniel J. Needleman, Jaimin S. Shah, Xingbo Yang, Tim Sanchez, William Conway, Marta Venturas
Publikováno v:
Human Reproduction. 37:411-427
STUDY QUESTION Can non-invasive metabolic imaging via fluorescence lifetime imaging microscopy (FLIM) detect variations in metabolic profiles between discarded human blastocysts? SUMMARY ANSWER FLIM revealed extensive variations in the metabolic stat